Free cationic liposomes inhibit the inflammatory response to cationic lipid–DNA complex injected intravenously and enhance its transfection efficiency

In this report, we show that intravenous (i.v.) injection into mice of a complex made of the cationic lipid diC14-amidine and the luciferase reporter plasmid (pCMV-luc) results in efficient gene expression in several organs but elicits an inflammatory response characterized by a release of tumor nec...

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Veröffentlicht in:	Molecular therapy 2003-01, Vol.7 (1), p.81-88
Hauptverfasser:	Elouahabi, Abdelatif, Flamand, Veronique, Ozkan, Sibel, Paulart, Frederic, Vandenbranden, Michel, Goldman, Michel, Ruysschaert, Jean-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations DNA - administration & dosage Experiments Gene expression Gene therapy Interferon-gamma - administration & dosage Lipids Lipids - administration & dosage Liposomes Mice Transfection - standards Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-TNF
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