Responses of neurons in ventroposterolateral nucleus of primate thalamus to urinary bladder distension
The purpose of this study was to examine effects of a noxious visceral stimulus, urinary bladder distension (UBD), on cells in the ventroposterolateral (VPL) nucleus of anesthetized monkeys. We hypothesized that processing of visceral information in the VPL nucleus of the thalamus is similar to spin...
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| Veröffentlicht in: | Brain research 1992-01, Vol.571 (1), p.26-34 |
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| creator | Chandler, Margaret J. Hobbs, Stuart F. Fu, Qing-Gong Kenshalo, Dan R. Blair, Robert W. Foreman, Robert D. |
| description | The purpose of this study was to examine effects of a noxious visceral stimulus, urinary bladder distension (UBD), on cells in the ventroposterolateral (VPL) nucleus of anesthetized monkeys. We hypothesized that processing of visceral information in the VPL nucleus of the thalamus is similar to spinothalamic tract (STT) organization of visceral afferent input. Urinary bladder distention excites sacral and upper-lumbar STT cells that have somatic input from proximal somatic fields
25; whereas, thoracic STT cells are inhibited by UBD
7. Extracellular action potentials of 67 neurons were recorded in VPL nucleus. Urinary bladder distention excited 22 cells, inhibited 9 cells, and did not affect activity of 36 cells. Seventeen of 22 cells excited by UBD also received convergent somatic input from noxious squeeze of the hip, groin, or perineal regions. No cells activated only by innocuous somatic stimuli were excited by UBD. Five of 9 cells inhibited by UBD had upper-body somatic fields. There was a significant tendency for VPL neurons excited by UBD to have proximal lower-body somatic fields that were excited by noxious stimulation of skin and underlying muscle (
P < 0.001). Antidromic activation of 4 thalamic neurons affected by UBD showed that visceral input stimulated by UBD reached the primary somatosensory (SI) cortex. |
| doi_str_mv | 10.1016/0006-8993(92)90506-5 |
| format | Article |
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25; whereas, thoracic STT cells are inhibited by UBD
7. Extracellular action potentials of 67 neurons were recorded in VPL nucleus. Urinary bladder distention excited 22 cells, inhibited 9 cells, and did not affect activity of 36 cells. Seventeen of 22 cells excited by UBD also received convergent somatic input from noxious squeeze of the hip, groin, or perineal regions. No cells activated only by innocuous somatic stimuli were excited by UBD. Five of 9 cells inhibited by UBD had upper-body somatic fields. There was a significant tendency for VPL neurons excited by UBD to have proximal lower-body somatic fields that were excited by noxious stimulation of skin and underlying muscle (
P < 0.001). Antidromic activation of 4 thalamic neurons affected by UBD showed that visceral input stimulated by UBD reached the primary somatosensory (SI) cortex.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(92)90506-5</identifier><identifier>PMID: 1611493</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Action Potentials ; Animals ; Biological and medical sciences ; Brain Mapping ; Catheterization ; Extracellular Space - physiology ; Fundamental and applied biological sciences. Psychology ; Macaca fascicularis ; Neurons - physiology ; Nociception ; Pain ; Physical Stimulation - methods ; Somatic afferent ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinothalamic tract ; Thalamic Nuclei - cytology ; Thalamic Nuclei - physiology ; Thalamocortical neuron ; Urinary Bladder - physiology ; Vertebrates: nervous system and sense organs ; Visceral afferent</subject><ispartof>Brain research, 1992-01, Vol.571 (1), p.26-34</ispartof><rights>1992 Elsevier Science Publishers B.V. All right reserved</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-679840c01900613bc3d965ef279a88b93373e6205a4b8521616a9cd63d48ba193</citedby><cites>FETCH-LOGICAL-c417t-679840c01900613bc3d965ef279a88b93373e6205a4b8521616a9cd63d48ba193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(92)90506-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5080955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1611493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandler, Margaret J.</creatorcontrib><creatorcontrib>Hobbs, Stuart F.</creatorcontrib><creatorcontrib>Fu, Qing-Gong</creatorcontrib><creatorcontrib>Kenshalo, Dan R.</creatorcontrib><creatorcontrib>Blair, Robert W.</creatorcontrib><creatorcontrib>Foreman, Robert D.</creatorcontrib><title>Responses of neurons in ventroposterolateral nucleus of primate thalamus to urinary bladder distension</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The purpose of this study was to examine effects of a noxious visceral stimulus, urinary bladder distension (UBD), on cells in the ventroposterolateral (VPL) nucleus of anesthetized monkeys. We hypothesized that processing of visceral information in the VPL nucleus of the thalamus is similar to spinothalamic tract (STT) organization of visceral afferent input. Urinary bladder distention excites sacral and upper-lumbar STT cells that have somatic input from proximal somatic fields
25; whereas, thoracic STT cells are inhibited by UBD
7. Extracellular action potentials of 67 neurons were recorded in VPL nucleus. Urinary bladder distention excited 22 cells, inhibited 9 cells, and did not affect activity of 36 cells. Seventeen of 22 cells excited by UBD also received convergent somatic input from noxious squeeze of the hip, groin, or perineal regions. No cells activated only by innocuous somatic stimuli were excited by UBD. Five of 9 cells inhibited by UBD had upper-body somatic fields. There was a significant tendency for VPL neurons excited by UBD to have proximal lower-body somatic fields that were excited by noxious stimulation of skin and underlying muscle (
P < 0.001). Antidromic activation of 4 thalamic neurons affected by UBD showed that visceral input stimulated by UBD reached the primary somatosensory (SI) cortex.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Catheterization</subject><subject>Extracellular Space - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Macaca fascicularis</subject><subject>Neurons - physiology</subject><subject>Nociception</subject><subject>Pain</subject><subject>Physical Stimulation - methods</subject><subject>Somatic afferent</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinothalamic tract</subject><subject>Thalamic Nuclei - cytology</subject><subject>Thalamic Nuclei - physiology</subject><subject>Thalamocortical neuron</subject><subject>Urinary Bladder - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visceral afferent</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV1LHTEQDUXR623_QQt5kNI-rM3HbjZ5EcqlVkEQpH0O2WSWpuQm12RX8N-b-4G-6UvCmTlzZuYMQp8puaCEih-EENFIpfg3xb4r0lXUfUALKnvWCNaSI7R4oZyis1L-V8i5IifohApKW8UXaLyHskmxQMFpxBHmXAH2ET9CnHLapDJBTsHU1wQcZxtg3lE32a9rFE__TDDrGpsSnrOPJj_hIRjnIGPna3UsPsWP6Hg0ocCnw79Ef69-_VldN7d3v29WP28b29J-akSvZEssoaoOTvlguVOig5H1ykg5KM57DoKRzrSD7FjdQhhlneCulYOhii_R173uJqeHGcqk175YCMFESHPRPSeUMcbfJVZpSfrabonaPdHmVEqGUe82z0-aEr29g96arLcma8X07g66q2VfDvrzsAb3WrQ3vubPD3lTrAljNtH68kLriCSq28pc7mlQTXv0kHWxHqIF5zPYSbvk357jGe08pFo</recordid><startdate>19920131</startdate><enddate>19920131</enddate><creator>Chandler, Margaret J.</creator><creator>Hobbs, Stuart F.</creator><creator>Fu, Qing-Gong</creator><creator>Kenshalo, Dan R.</creator><creator>Blair, Robert W.</creator><creator>Foreman, Robert D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920131</creationdate><title>Responses of neurons in ventroposterolateral nucleus of primate thalamus to urinary bladder distension</title><author>Chandler, Margaret J. ; Hobbs, Stuart F. ; Fu, Qing-Gong ; Kenshalo, Dan R. ; Blair, Robert W. ; Foreman, Robert D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-679840c01900613bc3d965ef279a88b93373e6205a4b8521616a9cd63d48ba193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Catheterization</topic><topic>Extracellular Space - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Macaca fascicularis</topic><topic>Neurons - physiology</topic><topic>Nociception</topic><topic>Pain</topic><topic>Physical Stimulation - methods</topic><topic>Somatic afferent</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinothalamic tract</topic><topic>Thalamic Nuclei - cytology</topic><topic>Thalamic Nuclei - physiology</topic><topic>Thalamocortical neuron</topic><topic>Urinary Bladder - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visceral afferent</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandler, Margaret J.</creatorcontrib><creatorcontrib>Hobbs, Stuart F.</creatorcontrib><creatorcontrib>Fu, Qing-Gong</creatorcontrib><creatorcontrib>Kenshalo, Dan R.</creatorcontrib><creatorcontrib>Blair, Robert W.</creatorcontrib><creatorcontrib>Foreman, Robert D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandler, Margaret J.</au><au>Hobbs, Stuart F.</au><au>Fu, Qing-Gong</au><au>Kenshalo, Dan R.</au><au>Blair, Robert W.</au><au>Foreman, Robert D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of neurons in ventroposterolateral nucleus of primate thalamus to urinary bladder distension</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1992-01-31</date><risdate>1992</risdate><volume>571</volume><issue>1</issue><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The purpose of this study was to examine effects of a noxious visceral stimulus, urinary bladder distension (UBD), on cells in the ventroposterolateral (VPL) nucleus of anesthetized monkeys. We hypothesized that processing of visceral information in the VPL nucleus of the thalamus is similar to spinothalamic tract (STT) organization of visceral afferent input. Urinary bladder distention excites sacral and upper-lumbar STT cells that have somatic input from proximal somatic fields
25; whereas, thoracic STT cells are inhibited by UBD
7. Extracellular action potentials of 67 neurons were recorded in VPL nucleus. Urinary bladder distention excited 22 cells, inhibited 9 cells, and did not affect activity of 36 cells. Seventeen of 22 cells excited by UBD also received convergent somatic input from noxious squeeze of the hip, groin, or perineal regions. No cells activated only by innocuous somatic stimuli were excited by UBD. Five of 9 cells inhibited by UBD had upper-body somatic fields. There was a significant tendency for VPL neurons excited by UBD to have proximal lower-body somatic fields that were excited by noxious stimulation of skin and underlying muscle (
P < 0.001). Antidromic activation of 4 thalamic neurons affected by UBD showed that visceral input stimulated by UBD reached the primary somatosensory (SI) cortex.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1611493</pmid><doi>10.1016/0006-8993(92)90506-5</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Action Potentials Animals Biological and medical sciences Brain Mapping Catheterization Extracellular Space - physiology Fundamental and applied biological sciences. Psychology Macaca fascicularis Neurons - physiology Nociception Pain Physical Stimulation - methods Somatic afferent Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinothalamic tract Thalamic Nuclei - cytology Thalamic Nuclei - physiology Thalamocortical neuron Urinary Bladder - physiology Vertebrates: nervous system and sense organs Visceral afferent |
| title | Responses of neurons in ventroposterolateral nucleus of primate thalamus to urinary bladder distension |
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