Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study
Objective Cartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature ind...
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| Veröffentlicht in: | Arthritis and rheumatism 2003-02, Vol.48 (2), p.396-403 |
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| container_title | Arthritis and rheumatism |
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| creator | Hooiveld, Michel J. J. Roosendaal, Goris Vianen, Marieke E. Van Den Berg, H. Marijke Bijlsma, Johannes W. J. Lafeber, Floris P. J. G. |
| description | Objective
Cartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature individuals, as suggested by clinical practice experience with humans.
Methods
Right knees of 3 groups of 6 beagle dogs (skeletally immature, young mature, and old animals) were injected with autologous blood on days 0 and 2. On day 4, cartilage matrix proteoglycan turnover (content, synthesis, and release), synovial inflammation, and cartilage‐destructive properties of the synovial tissue were determined and compared with those of the left uninjected control knees.
Results
Subsequent to intraarticular bleeding, cartilage proteoglycan content decreased in an age‐dependent manner, with the largest decrease occurring in cartilage of immature animals. Proteoglycan synthesis per cell also decreased in an age‐dependent manner, with the largest decrease occurring in the immature animals. Cartilage proteoglycan release increased in all 3 groups, but the decrease was not age dependent. Interestingly, immature animals showed a large increase in cartilage DNA content upon exposure to blood, whereas mature animals did not. Histologic analysis showed a mild synovitis in animals of all ages, but catabolic inflammatory activity was found only in immature animals.
Conclusion
Joints of skeletally immature dogs appeared to be more susceptible than joints of mature dogs to the adverse effects of a joint hemorrhage. These data suggest that for humans, specifically young children are at risk for joint damage after a joint hemorrhage. |
| doi_str_mv | 10.1002/art.10769 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73010596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73010596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3829-1f026ef749c64747ce3a427d3db04a97faf0796b12b685dd8c0cff1074c662443</originalsourceid><addsrcrecordid>eNqFkctKAzEUhoMotl4WvoBko-CimttMJu5K8VIQBNH1kMlFI5mZmsxUuhN8AZ_RJzG1ha5ECOQczsd_-M8PwBFG5xghciFDlwqeiy0wxBkRI4Qp3gZDhBAb0UzgAdiL8TW1hGZ0FwwwyTgumBiCz2ldy64PBiYRp3ovA1TL0stnA12EdZtmsY_KzDpXeQO7Fla-bfX3x5drdK-MhlrWS7p7kQ38W-0SjhvoGjh38xbKxtXSw9j1enEAdqz00Ryu_33wdH31OLkd3d3fTCfju5GiRTKFLSK5sZwJlTPOuDJUMsI11RViUnArLeIirzCp8iLTulBIWZvuwlSeE8boPjhd6c5C-9ab2JW1S768l41p-1hyijDKRP4viAuRHkcJPFuBKrQxBmPLWUi-wqLEqFxGUybz5W80iT1ei_ZVbfSGXGeRgJM1IKOS3gbZKBc3HMuYIGLJXay4d-fN4u-N5fjhcbX6B2w8p8E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18918970</pqid></control><display><type>article</type><title>Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hooiveld, Michel J. J. ; Roosendaal, Goris ; Vianen, Marieke E. ; Van Den Berg, H. Marijke ; Bijlsma, Johannes W. J. ; Lafeber, Floris P. J. G.</creator><creatorcontrib>Hooiveld, Michel J. J. ; Roosendaal, Goris ; Vianen, Marieke E. ; Van Den Berg, H. Marijke ; Bijlsma, Johannes W. J. ; Lafeber, Floris P. J. G.</creatorcontrib><description>Objective
Cartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature individuals, as suggested by clinical practice experience with humans.
Methods
Right knees of 3 groups of 6 beagle dogs (skeletally immature, young mature, and old animals) were injected with autologous blood on days 0 and 2. On day 4, cartilage matrix proteoglycan turnover (content, synthesis, and release), synovial inflammation, and cartilage‐destructive properties of the synovial tissue were determined and compared with those of the left uninjected control knees.
Results
Subsequent to intraarticular bleeding, cartilage proteoglycan content decreased in an age‐dependent manner, with the largest decrease occurring in cartilage of immature animals. Proteoglycan synthesis per cell also decreased in an age‐dependent manner, with the largest decrease occurring in the immature animals. Cartilage proteoglycan release increased in all 3 groups, but the decrease was not age dependent. Interestingly, immature animals showed a large increase in cartilage DNA content upon exposure to blood, whereas mature animals did not. Histologic analysis showed a mild synovitis in animals of all ages, but catabolic inflammatory activity was found only in immature animals.
Conclusion
Joints of skeletally immature dogs appeared to be more susceptible than joints of mature dogs to the adverse effects of a joint hemorrhage. These data suggest that for humans, specifically young children are at risk for joint damage after a joint hemorrhage.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.10769</identifier><identifier>PMID: 12571849</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Age Factors ; Animals ; Biological and medical sciences ; Blood ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Dogs ; Female ; Hemorrhage - complications ; Hemorrhage - metabolism ; Hemorrhage - pathology ; Injections, Intra-Articular ; Investigative techniques, diagnostic techniques (general aspects) ; Knee Joint - metabolism ; Knee Joint - pathology ; Medical sciences ; Osteoarticular system. Muscles ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proteoglycans - metabolism ; Synovial Membrane - metabolism ; Synovial Membrane - pathology</subject><ispartof>Arthritis and rheumatism, 2003-02, Vol.48 (2), p.396-403</ispartof><rights>Copyright © 2003 by the American College of Rheumatology</rights><rights>2003 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3829-1f026ef749c64747ce3a427d3db04a97faf0796b12b685dd8c0cff1074c662443</citedby><cites>FETCH-LOGICAL-c3829-1f026ef749c64747ce3a427d3db04a97faf0796b12b685dd8c0cff1074c662443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.10769$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.10769$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14549299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12571849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hooiveld, Michel J. J.</creatorcontrib><creatorcontrib>Roosendaal, Goris</creatorcontrib><creatorcontrib>Vianen, Marieke E.</creatorcontrib><creatorcontrib>Van Den Berg, H. Marijke</creatorcontrib><creatorcontrib>Bijlsma, Johannes W. J.</creatorcontrib><creatorcontrib>Lafeber, Floris P. J. G.</creatorcontrib><title>Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
Cartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature individuals, as suggested by clinical practice experience with humans.
Methods
Right knees of 3 groups of 6 beagle dogs (skeletally immature, young mature, and old animals) were injected with autologous blood on days 0 and 2. On day 4, cartilage matrix proteoglycan turnover (content, synthesis, and release), synovial inflammation, and cartilage‐destructive properties of the synovial tissue were determined and compared with those of the left uninjected control knees.
Results
Subsequent to intraarticular bleeding, cartilage proteoglycan content decreased in an age‐dependent manner, with the largest decrease occurring in cartilage of immature animals. Proteoglycan synthesis per cell also decreased in an age‐dependent manner, with the largest decrease occurring in the immature animals. Cartilage proteoglycan release increased in all 3 groups, but the decrease was not age dependent. Interestingly, immature animals showed a large increase in cartilage DNA content upon exposure to blood, whereas mature animals did not. Histologic analysis showed a mild synovitis in animals of all ages, but catabolic inflammatory activity was found only in immature animals.
Conclusion
Joints of skeletally immature dogs appeared to be more susceptible than joints of mature dogs to the adverse effects of a joint hemorrhage. These data suggest that for humans, specifically young children are at risk for joint damage after a joint hemorrhage.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Hemorrhage - complications</subject><subject>Hemorrhage - metabolism</subject><subject>Hemorrhage - pathology</subject><subject>Injections, Intra-Articular</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Knee Joint - metabolism</subject><subject>Knee Joint - pathology</subject><subject>Medical sciences</subject><subject>Osteoarticular system. Muscles</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Proteoglycans - metabolism</subject><subject>Synovial Membrane - metabolism</subject><subject>Synovial Membrane - pathology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKAzEUhoMotl4WvoBko-CimttMJu5K8VIQBNH1kMlFI5mZmsxUuhN8AZ_RJzG1ha5ECOQczsd_-M8PwBFG5xghciFDlwqeiy0wxBkRI4Qp3gZDhBAb0UzgAdiL8TW1hGZ0FwwwyTgumBiCz2ldy64PBiYRp3ovA1TL0stnA12EdZtmsY_KzDpXeQO7Fla-bfX3x5drdK-MhlrWS7p7kQ38W-0SjhvoGjh38xbKxtXSw9j1enEAdqz00Ryu_33wdH31OLkd3d3fTCfju5GiRTKFLSK5sZwJlTPOuDJUMsI11RViUnArLeIirzCp8iLTulBIWZvuwlSeE8boPjhd6c5C-9ab2JW1S768l41p-1hyijDKRP4viAuRHkcJPFuBKrQxBmPLWUi-wqLEqFxGUybz5W80iT1ei_ZVbfSGXGeRgJM1IKOS3gbZKBc3HMuYIGLJXay4d-fN4u-N5fjhcbX6B2w8p8E</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Hooiveld, Michel J. J.</creator><creator>Roosendaal, Goris</creator><creator>Vianen, Marieke E.</creator><creator>Van Den Berg, H. Marijke</creator><creator>Bijlsma, Johannes W. J.</creator><creator>Lafeber, Floris P. J. G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study</title><author>Hooiveld, Michel J. J. ; Roosendaal, Goris ; Vianen, Marieke E. ; Van Den Berg, H. Marijke ; Bijlsma, Johannes W. J. ; Lafeber, Floris P. J. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3829-1f026ef749c64747ce3a427d3db04a97faf0796b12b685dd8c0cff1074c662443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>Hemorrhage - complications</topic><topic>Hemorrhage - metabolism</topic><topic>Hemorrhage - pathology</topic><topic>Injections, Intra-Articular</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Knee Joint - metabolism</topic><topic>Knee Joint - pathology</topic><topic>Medical sciences</topic><topic>Osteoarticular system. Muscles</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Proteoglycans - metabolism</topic><topic>Synovial Membrane - metabolism</topic><topic>Synovial Membrane - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Hooiveld, Michel J. J.</creatorcontrib><creatorcontrib>Roosendaal, Goris</creatorcontrib><creatorcontrib>Vianen, Marieke E.</creatorcontrib><creatorcontrib>Van Den Berg, H. Marijke</creatorcontrib><creatorcontrib>Bijlsma, Johannes W. J.</creatorcontrib><creatorcontrib>Lafeber, Floris P. J. G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hooiveld, Michel J. J.</au><au>Roosendaal, Goris</au><au>Vianen, Marieke E.</au><au>Van Den Berg, H. Marijke</au><au>Bijlsma, Johannes W. J.</au><au>Lafeber, Floris P. J. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>2003-02</date><risdate>2003</risdate><volume>48</volume><issue>2</issue><spage>396</spage><epage>403</epage><pages>396-403</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective
Cartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature individuals, as suggested by clinical practice experience with humans.
Methods
Right knees of 3 groups of 6 beagle dogs (skeletally immature, young mature, and old animals) were injected with autologous blood on days 0 and 2. On day 4, cartilage matrix proteoglycan turnover (content, synthesis, and release), synovial inflammation, and cartilage‐destructive properties of the synovial tissue were determined and compared with those of the left uninjected control knees.
Results
Subsequent to intraarticular bleeding, cartilage proteoglycan content decreased in an age‐dependent manner, with the largest decrease occurring in cartilage of immature animals. Proteoglycan synthesis per cell also decreased in an age‐dependent manner, with the largest decrease occurring in the immature animals. Cartilage proteoglycan release increased in all 3 groups, but the decrease was not age dependent. Interestingly, immature animals showed a large increase in cartilage DNA content upon exposure to blood, whereas mature animals did not. Histologic analysis showed a mild synovitis in animals of all ages, but catabolic inflammatory activity was found only in immature animals.
Conclusion
Joints of skeletally immature dogs appeared to be more susceptible than joints of mature dogs to the adverse effects of a joint hemorrhage. These data suggest that for humans, specifically young children are at risk for joint damage after a joint hemorrhage.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12571849</pmid><doi>10.1002/art.10769</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Arthritis and rheumatism, 2003-02, Vol.48 (2), p.396-403 |
| issn | 0004-3591 1529-0131 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73010596 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Animals Biological and medical sciences Blood Cartilage, Articular - metabolism Cartilage, Articular - pathology Dogs Female Hemorrhage - complications Hemorrhage - metabolism Hemorrhage - pathology Injections, Intra-Articular Investigative techniques, diagnostic techniques (general aspects) Knee Joint - metabolism Knee Joint - pathology Medical sciences Osteoarticular system. Muscles Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteoglycans - metabolism Synovial Membrane - metabolism Synovial Membrane - pathology |
| title | Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study |
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