Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat
In 90 rats a colonic anastornosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with, fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days...
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| Veröffentlicht in: | British journal of surgery 1992-06, Vol.79 (6), p.525-528 |
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| container_title | British journal of surgery |
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| creator | van der Ham, A. C. Kort, W. J. Weijma, I. M. van den Ingh, H. F. G. M. Jeekel, H. |
| description | In 90 rats a colonic anastornosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with, fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days 2, 4 and 7, ten animals in each group were killed. Adhesion formation was significantly increased in groups 2 and 3 compared with the control group. On day 2 the anastomosis was significantly stronger after sealing with antibiotic–fibrin mixture. On day 4 the bursting pressure in group 2 was significantly lower than in groups 1 and 3. At the same time the concentration of hydroxyproline was significantly reduced in group 2, but not in group 3. The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation. |
| doi_str_mv | 10.1002/bjs.1800790617 |
| format | Article |
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The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800790617</identifier><identifier>PMID: 1611443</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Anastomosis, Surgical ; Animals ; Anti-Bacterial Agents - pharmacology ; Collagen - metabolism ; Colon - metabolism ; Colon - pathology ; Colon - surgery ; Colonic Diseases - etiology ; Fibrin Tissue Adhesive - pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Tissue Adhesions - etiology ; Wound Healing - drug effects</subject><ispartof>British journal of surgery, 1992-06, Vol.79 (6), p.525-528</ispartof><rights>Copyright © 1992 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3797-32d3ba491f28915ed791c0a3126c7075b4b495795266aa7e235bc8c63a7aed683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800790617$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800790617$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1611443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Ham, A. 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On day 4 the bursting pressure in group 2 was significantly lower than in groups 1 and 3. At the same time the concentration of hydroxyproline was significantly reduced in group 2, but not in group 3. The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Collagen - metabolism</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Colon - surgery</subject><subject>Colonic Diseases - etiology</subject><subject>Fibrin Tissue Adhesive - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Adhesions - etiology</subject><subject>Wound Healing - drug effects</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EKqWwsiFlYkuxfYkdj4BKC6pAiAKj5TgOdUniEqeC_ntcWtHpPt57TncvQucEDwnG9Cpf-CHJMOYCM8IPUJ8AS2NKWHaI-jj0YwIUjtGJ9wuMCeCU9lCPMEKSBProeVSWRneRKyPVdDa3rrPaR7aJSpu3IXijqqBEronmIbXNR6Rd5RqrA6B852rnzR_QzU3Uqu4UHZWq8uZsFwfo9W40u53E06fx_e31NNbABY-BFpCrRJCSZoKkpuCCaKyAUKY55mme5IlIuUgpY0pxQyHNdaYZKK5MwTIYoMvt3mXrvlbGd7K2XpsqXGvcyksOmGweDoMXu8FVXptCLltbq3Ytdx4EXWz1b1uZ9V7GcmOwDAbLvcHy5uFlXwU23rLWd-bnn1Xtp2QceCrfH8dyImYJ0DcqAX4BXsh8qA</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>van der Ham, A. 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M.</creatorcontrib><creatorcontrib>van den Ingh, H. F. G. M.</creatorcontrib><creatorcontrib>Jeekel, H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Ham, A. C.</au><au>Kort, W. J.</au><au>Weijma, I. M.</au><au>van den Ingh, H. F. G. M.</au><au>Jeekel, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1992-06</date><risdate>1992</risdate><volume>79</volume><issue>6</issue><spage>525</spage><epage>528</epage><pages>525-528</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>In 90 rats a colonic anastornosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with, fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days 2, 4 and 7, ten animals in each group were killed. Adhesion formation was significantly increased in groups 2 and 3 compared with the control group. On day 2 the anastomosis was significantly stronger after sealing with antibiotic–fibrin mixture. On day 4 the bursting pressure in group 2 was significantly lower than in groups 1 and 3. At the same time the concentration of hydroxyproline was significantly reduced in group 2, but not in group 3. The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1611443</pmid><doi>10.1002/bjs.1800790617</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 1992-06, Vol.79 (6), p.525-528 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anastomosis, Surgical Animals Anti-Bacterial Agents - pharmacology Collagen - metabolism Colon - metabolism Colon - pathology Colon - surgery Colonic Diseases - etiology Fibrin Tissue Adhesive - pharmacology Male Rats Rats, Inbred Strains Tissue Adhesions - etiology Wound Healing - drug effects |
| title | Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat |
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