Influence of the catechol‐O‐methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women

BACKGROUND: Catechol‐O‐methyltransferase (COMT) is the principal enzyme in the conjugation pathway for hydroxylated estrogens. We hypothesize that blood 17β‐estradiol (E2) and estrone (E1) levels in postmenopausal women receiving an oral E2 preparation are dependent on the enzyme activity of COMT. M...

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Veröffentlicht in:	Human reproduction (Oxford) 2003-02, Vol.18 (2), p.262-266
Hauptverfasser:	Worda, C., Sator, M.O., Schneeberger, C., Jantschev, T., Ferlitsch, K., Huber, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Body Mass Index Body Weight Catechol O-Methyltransferase - genetics Codon - genetics Estradiol - administration & dosage Estradiol - blood Estrogen Replacement Therapy Estrone - blood Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotype Hormones. Endocrine system Human Humans Key words: codon 158 polymorphism/COMT/estrogen levels/hormone replacement therapy/menarche Medical sciences Middle Aged Pharmacology. Drug treatments Polymorphism, Genetic Population genetics, reproduction patterns Postmenopause - blood
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