In vivo 7Li NMR imaging and localized spectroscopy of rat brain
Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li f...
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| Veröffentlicht in: | Magnetic resonance in medicine 1992-06, Vol.25 (2), p.308-318 |
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| container_title | Magnetic resonance in medicine |
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| creator | Ramaprasad, S. Newton, J. E. O. Cardwell, D. Fowler, A. H. Komoroski, R. A. |
| description | Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a 1H‐7Li double coil assembly,7Li images were generated for rat head, as was the corresponding 1H image for anatomic localization. The 7Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on 7Li images, the Li level in muscle was about twice that in the brain. Variations of 7Li intensity level across the brain were typically small. © 1992 Academic Press, Inc. |
| doi_str_mv | 10.1002/mrm.1910250209 |
| format | Article |
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E. O. ; Cardwell, D. ; Fowler, A. H. ; Komoroski, R. A.</creator><creatorcontrib>Ramaprasad, S. ; Newton, J. E. O. ; Cardwell, D. ; Fowler, A. H. ; Komoroski, R. A.</creatorcontrib><description>Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a 1H‐7Li double coil assembly,7Li images were generated for rat head, as was the corresponding 1H image for anatomic localization. The 7Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on 7Li images, the Li level in muscle was about twice that in the brain. Variations of 7Li intensity level across the brain were typically small. © 1992 Academic Press, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910250209</identifier><identifier>PMID: 1614314</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Brain - anatomy & histology ; Brain - metabolism ; Brain - pathology ; Investigative techniques, diagnostic techniques (general aspects) ; Lithium - pharmacokinetics ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Inbred Strains</subject><ispartof>Magnetic resonance in medicine, 1992-06, Vol.25 (2), p.308-318</ispartof><rights>Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910250209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910250209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5481501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1614314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramaprasad, S.</creatorcontrib><creatorcontrib>Newton, J. E. O.</creatorcontrib><creatorcontrib>Cardwell, D.</creatorcontrib><creatorcontrib>Fowler, A. H.</creatorcontrib><creatorcontrib>Komoroski, R. A.</creatorcontrib><title>In vivo 7Li NMR imaging and localized spectroscopy of rat brain</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a 1H‐7Li double coil assembly,7Li images were generated for rat head, as was the corresponding 1H image for anatomic localization. The 7Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on 7Li images, the Li level in muscle was about twice that in the brain. Variations of 7Li intensity level across the brain were typically small. © 1992 Academic Press, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lithium - pharmacokinetics</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLK0EQhRu5ovGxdSf04uJutPo1Pb0SyfWFiYooLptKT4-0ziO3O1Hjr3ckwdSmKM53Cs4h5IDBMQPgJ01sjplhwBVwMBtkwBTnGVdG_iED0BIywYzcJjspvQKAMVpukS2WMymYHJDT65a-h_eO6lGgt-MHGhp8Ce0LxbakdeewDl--pGnq3Sx2yXXTBe0qGnFGJxFDu0c2K6yT31_tXfJ0cf44vMpGd5fXw7NRFpgGk3mmilyaAhCl6keUBUNfeSyNKlXpNAJyl1cTMNJVXHifoysFg1x6jgbELjla_p3G7v_cp5ltQnK-rrH13TxZLQCKQpgePFyB80njSzuNfaK4sKvEvf53pWPq01URWxfSL6ZkwRSwHjNL7CPUfrH-Avanddu3btet2_HDeH313mzpDWnmP3-9GN9sroVW9vn20g71vxsxvH-29-IbnAqDPQ</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>Ramaprasad, S.</creator><creator>Newton, J. E. O.</creator><creator>Cardwell, D.</creator><creator>Fowler, A. H.</creator><creator>Komoroski, R. A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199206</creationdate><title>In vivo 7Li NMR imaging and localized spectroscopy of rat brain</title><author>Ramaprasad, S. ; Newton, J. E. O. ; Cardwell, D. ; Fowler, A. H. ; Komoroski, R. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1709-e15864980aa455553d81aefead95d5dc7a0a2c6fb094cf23ee6acd31064e2a903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lithium - pharmacokinetics</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramaprasad, S.</creatorcontrib><creatorcontrib>Newton, J. E. O.</creatorcontrib><creatorcontrib>Cardwell, D.</creatorcontrib><creatorcontrib>Fowler, A. H.</creatorcontrib><creatorcontrib>Komoroski, R. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramaprasad, S.</au><au>Newton, J. E. O.</au><au>Cardwell, D.</au><au>Fowler, A. H.</au><au>Komoroski, R. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo 7Li NMR imaging and localized spectroscopy of rat brain</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1992-06</date><risdate>1992</risdate><volume>25</volume><issue>2</issue><spage>308</spage><epage>318</epage><pages>308-318</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a 1H‐7Li double coil assembly,7Li images were generated for rat head, as was the corresponding 1H image for anatomic localization. The 7Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on 7Li images, the Li level in muscle was about twice that in the brain. Variations of 7Li intensity level across the brain were typically small. © 1992 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1614314</pmid><doi>10.1002/mrm.1910250209</doi><tpages>11</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1992-06, Vol.25 (2), p.308-318 |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals Biological and medical sciences Brain - anatomy & histology Brain - metabolism Brain - pathology Investigative techniques, diagnostic techniques (general aspects) Lithium - pharmacokinetics Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Medical sciences Nervous system Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred Strains |
| title | In vivo 7Li NMR imaging and localized spectroscopy of rat brain |
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