The effects of acute ethanol on growth in rat liver: Steady state c- myc transcripts
In order to elucidate the effects of acute ethanol on compensatory liver growth (regeneration), the steady state c- myc mRNA levels were studied following two-thirds partial hepatectomy. After surgery, control rat livers exhibited two peaks of c- myc transcripts, at 0.5–2 h and at 8–10 h. Sham surge...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 1992-05, Vol.9 (3), p.279-282 |
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| container_title | Alcohol (Fayetteville, N.Y.) |
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| creator | Lumpkin, C.K. Taylor, J.M. Tarpley, M.D. Hayden, J.B. Badger, T.M. McClung, J.K. |
| description | In order to elucidate the effects of acute ethanol on compensatory liver growth (regeneration), the steady state c-
myc mRNA levels were studied following two-thirds partial hepatectomy. After surgery, control rat livers exhibited two peaks of c-
myc transcripts, at 0.5–2 h and at 8–10 h. Sham surgery did not induce c-
myc mRNA expression. Ethanol (3 g/kg), administered by gavage at 1 hour prehepatectomy, had no effect on the initial peak of c-
myc mRNA; however, the second peak was eliminated. Control gavage of isocaloric glucose prior to partial hepatectomy had no effects on either of the subsequent c-
myc mRNA peaks. Blood alcohol levels were found to be elevated throughout the prereplicative phase. These results suggest that ethanol may disrupt proto-oncogene expression near the restriction point at the G1/S boundary of the cell cycle in hepatocytes. |
| doi_str_mv | 10.1016/0741-8329(92)90066-J |
| format | Article |
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myc mRNA levels were studied following two-thirds partial hepatectomy. After surgery, control rat livers exhibited two peaks of c-
myc transcripts, at 0.5–2 h and at 8–10 h. Sham surgery did not induce c-
myc mRNA expression. Ethanol (3 g/kg), administered by gavage at 1 hour prehepatectomy, had no effect on the initial peak of c-
myc mRNA; however, the second peak was eliminated. Control gavage of isocaloric glucose prior to partial hepatectomy had no effects on either of the subsequent c-
myc mRNA peaks. Blood alcohol levels were found to be elevated throughout the prereplicative phase. These results suggest that ethanol may disrupt proto-oncogene expression near the restriction point at the G1/S boundary of the cell cycle in hepatocytes.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/0741-8329(92)90066-J</identifier><identifier>PMID: 1605896</identifier><identifier>CODEN: ALCOEX</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Blotting, Northern ; c- myc ; Ethanol ; Ethanol - blood ; Ethanol - pharmacology ; Hepatectomy - methods ; Homeostasis ; Liver ; Liver - metabolism ; Liver Regeneration - drug effects ; Male ; Medical sciences ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; Protooncogene ; Rats ; Rats, Inbred Strains ; Regeneration ; RNA, Messenger - metabolism ; Time Factors ; Toxicology ; Transcription, Genetic</subject><ispartof>Alcohol (Fayetteville, N.Y.), 1992-05, Vol.9 (3), p.279-282</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-50612f144ac1658e2d1cef8e843efccee504664b6f621ffb4b8520dc59cf3043</citedby><cites>FETCH-LOGICAL-c417t-50612f144ac1658e2d1cef8e843efccee504664b6f621ffb4b8520dc59cf3043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0741-8329(92)90066-J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5476884$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1605896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lumpkin, C.K.</creatorcontrib><creatorcontrib>Taylor, J.M.</creatorcontrib><creatorcontrib>Tarpley, M.D.</creatorcontrib><creatorcontrib>Hayden, J.B.</creatorcontrib><creatorcontrib>Badger, T.M.</creatorcontrib><creatorcontrib>McClung, J.K.</creatorcontrib><title>The effects of acute ethanol on growth in rat liver: Steady state c- myc transcripts</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>In order to elucidate the effects of acute ethanol on compensatory liver growth (regeneration), the steady state c-
myc mRNA levels were studied following two-thirds partial hepatectomy. After surgery, control rat livers exhibited two peaks of c-
myc transcripts, at 0.5–2 h and at 8–10 h. Sham surgery did not induce c-
myc mRNA expression. Ethanol (3 g/kg), administered by gavage at 1 hour prehepatectomy, had no effect on the initial peak of c-
myc mRNA; however, the second peak was eliminated. Control gavage of isocaloric glucose prior to partial hepatectomy had no effects on either of the subsequent c-
myc mRNA peaks. Blood alcohol levels were found to be elevated throughout the prereplicative phase. These results suggest that ethanol may disrupt proto-oncogene expression near the restriction point at the G1/S boundary of the cell cycle in hepatocytes.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>c- myc</subject><subject>Ethanol</subject><subject>Ethanol - blood</subject><subject>Ethanol - pharmacology</subject><subject>Hepatectomy - methods</subject><subject>Homeostasis</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver Regeneration - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>Protooncogene</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Regeneration</subject><subject>RNA, Messenger - metabolism</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Transcription, Genetic</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEQgC0EKqHwD0DyASE4bBl7vX5wQEIVj1aVOJC75cyOidFmN9hOUf49GxKVW3saaeab0cw3jL0UcCFA6PdglGhsK91bJ985AK2b60dsIaxpG21l-5gt7pCn7FkpvwDAGOPO2JnQ0FmnF2y5XBOnGAlr4VPkAXd1TtR1GKeBTyP_mac_dc3TyHOofEi3lD_wH5VCv-elhhnGhm_2yGsOY8GctrU8Z09iGAq9OMVztvzyeXn5rbn5_vXq8tNNg0qY2nSghYxCqYBCd5ZkL5CiJataiohEHSit1UpHLUWMK7WynYQeO4exBdWeszfHsds8_d5RqX6TCtIwhJGmXfGmBbCddg-CQkvjNMgZVEcQ81RKpui3OW1C3nsB_iDdH4z6g1HvpP8n3V_Pba9O83erDfX_m46W5_rrUz0UDEOcTWEqd1injLb2cM_HI0azs9tE2RdMNCL1Kc__8f2U7t_jL2jOnQo</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Lumpkin, C.K.</creator><creator>Taylor, J.M.</creator><creator>Tarpley, M.D.</creator><creator>Hayden, J.B.</creator><creator>Badger, T.M.</creator><creator>McClung, J.K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>The effects of acute ethanol on growth in rat liver: Steady state c- myc transcripts</title><author>Lumpkin, C.K. ; Taylor, J.M. ; Tarpley, M.D. ; Hayden, J.B. ; Badger, T.M. ; McClung, J.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-50612f144ac1658e2d1cef8e843efccee504664b6f621ffb4b8520dc59cf3043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>c- myc</topic><topic>Ethanol</topic><topic>Ethanol - blood</topic><topic>Ethanol - pharmacology</topic><topic>Hepatectomy - methods</topic><topic>Homeostasis</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver Regeneration - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>Protooncogene</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Regeneration</topic><topic>RNA, Messenger - metabolism</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lumpkin, C.K.</creatorcontrib><creatorcontrib>Taylor, J.M.</creatorcontrib><creatorcontrib>Tarpley, M.D.</creatorcontrib><creatorcontrib>Hayden, J.B.</creatorcontrib><creatorcontrib>Badger, T.M.</creatorcontrib><creatorcontrib>McClung, J.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lumpkin, C.K.</au><au>Taylor, J.M.</au><au>Tarpley, M.D.</au><au>Hayden, J.B.</au><au>Badger, T.M.</au><au>McClung, J.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of acute ethanol on growth in rat liver: Steady state c- myc transcripts</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>9</volume><issue>3</issue><spage>279</spage><epage>282</epage><pages>279-282</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><coden>ALCOEX</coden><abstract>In order to elucidate the effects of acute ethanol on compensatory liver growth (regeneration), the steady state c-
myc mRNA levels were studied following two-thirds partial hepatectomy. After surgery, control rat livers exhibited two peaks of c-
myc transcripts, at 0.5–2 h and at 8–10 h. Sham surgery did not induce c-
myc mRNA expression. Ethanol (3 g/kg), administered by gavage at 1 hour prehepatectomy, had no effect on the initial peak of c-
myc mRNA; however, the second peak was eliminated. Control gavage of isocaloric glucose prior to partial hepatectomy had no effects on either of the subsequent c-
myc mRNA peaks. Blood alcohol levels were found to be elevated throughout the prereplicative phase. These results suggest that ethanol may disrupt proto-oncogene expression near the restriction point at the G1/S boundary of the cell cycle in hepatocytes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1605896</pmid><doi>10.1016/0741-8329(92)90066-J</doi><tpages>4</tpages></addata></record> |
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| ispartof | Alcohol (Fayetteville, N.Y.), 1992-05, Vol.9 (3), p.279-282 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Blotting, Northern c- myc Ethanol Ethanol - blood Ethanol - pharmacology Hepatectomy - methods Homeostasis Liver Liver - metabolism Liver Regeneration - drug effects Male Medical sciences Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Protooncogene Rats Rats, Inbred Strains Regeneration RNA, Messenger - metabolism Time Factors Toxicology Transcription, Genetic |
| title | The effects of acute ethanol on growth in rat liver: Steady state c- myc transcripts |
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