AV3V lesion suppresses the pressor, dipsogenic and natriuretic responses to cholinergic activation of the septal area in rats
In the present study we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, dipsogenic, natriuretic and kaliuretic responses induced by the injection of carbachol (a cholinergic agonist) into the medial septal area (MSA) of rats. Male rats with sham or AV3V lesion and...
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| Veröffentlicht in: | Brain research 1992-02, Vol.572 (1), p.172-175 |
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| creator | Colombari, Eduardo Abra˜o Saad, Wilson de Arruda Camargo, Luiz Antonio Renzi, Antonio De Luca, Laurival Antonio Vanderlei Menani, José |
| description | In the present study we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, dipsogenic, natriuretic and kaliuretic responses induced by the injection of carbachol (a cholinergic agonist) into the medial septal area (MSA) of rats. Male rats with sham or AV3V lesion and a stainless-steel cannula implanted into the MSA were used. Carbachol (2 nmol) injected into the MSA in sham lesion rats produced pressor (43 ± 2mmHg), dipsogenic (9.6 ± 1.2ml/h), natriuretic (531 ± 82 μEq/120min) and kaliuretic (164 ± 14 μEq/120min) responses. In AV3V-lesioned rats (1–5 days and 14–18 days), the pressor (11 ± 2 and 14 ± 2mmHg, respectively), dipsogenic (1.9 ± 0.7 and 1.4 ± 0.6ml/h), natriuretic (21 ± 5 and 159 ± 44 μEq/120min) and kaliuretic (124 ± 14 and 86 ± 13 μEq/120min) responeses induced by carbachol injection into the MSA were reduced. These results show that the AV3V region is essential for the pressor, dipsogenic, natriuretic and kaliuretic responses induced by cholinergic activation of the MSA in rats. |
| doi_str_mv | 10.1016/0006-8993(92)90466-M |
| format | Article |
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Male rats with sham or AV3V lesion and a stainless-steel cannula implanted into the MSA were used. Carbachol (2 nmol) injected into the MSA in sham lesion rats produced pressor (43 ± 2mmHg), dipsogenic (9.6 ± 1.2ml/h), natriuretic (531 ± 82 μEq/120min) and kaliuretic (164 ± 14 μEq/120min) responses. In AV3V-lesioned rats (1–5 days and 14–18 days), the pressor (11 ± 2 and 14 ± 2mmHg, respectively), dipsogenic (1.9 ± 0.7 and 1.4 ± 0.6ml/h), natriuretic (21 ± 5 and 159 ± 44 μEq/120min) and kaliuretic (124 ± 14 and 86 ± 13 μEq/120min) responeses induced by carbachol injection into the MSA were reduced. These results show that the AV3V region is essential for the pressor, dipsogenic, natriuretic and kaliuretic responses induced by cholinergic activation of the MSA in rats.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(92)90466-M</identifier><identifier>PMID: 1611511</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Arterial pressure ; AV3V region ; Biological and medical sciences ; Blood Pressure - drug effects ; Carbachol - pharmacology ; Cerebral Ventricles - physiology ; Electrolyte balance ; Fluid balance ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Hypothalamus ; Male ; Metabolisms and neurohumoral controls ; Natriuresis - drug effects ; Potassium - urine ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic - drug effects ; Septal area ; Septum Pellucidum - drug effects ; Thirst - drug effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Water and mineral metabolism. Osmoregulation. Acidobasic balance ; Water intake</subject><ispartof>Brain research, 1992-02, Vol.572 (1), p.172-175</ispartof><rights>1992 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a8b1159b2c564cdc75198c46de2e2d52a76dec81d322682fbd3f15fea8f0e9103</citedby><cites>FETCH-LOGICAL-c417t-a8b1159b2c564cdc75198c46de2e2d52a76dec81d322682fbd3f15fea8f0e9103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(92)90466-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5171862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1611511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colombari, Eduardo</creatorcontrib><creatorcontrib>Abra˜o Saad, Wilson</creatorcontrib><creatorcontrib>de Arruda Camargo, Luiz Antonio</creatorcontrib><creatorcontrib>Renzi, Antonio</creatorcontrib><creatorcontrib>De Luca, Laurival Antonio</creatorcontrib><creatorcontrib>Vanderlei Menani, José</creatorcontrib><title>AV3V lesion suppresses the pressor, dipsogenic and natriuretic responses to cholinergic activation of the septal area in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>In the present study we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, dipsogenic, natriuretic and kaliuretic responses induced by the injection of carbachol (a cholinergic agonist) into the medial septal area (MSA) of rats. Male rats with sham or AV3V lesion and a stainless-steel cannula implanted into the MSA were used. Carbachol (2 nmol) injected into the MSA in sham lesion rats produced pressor (43 ± 2mmHg), dipsogenic (9.6 ± 1.2ml/h), natriuretic (531 ± 82 μEq/120min) and kaliuretic (164 ± 14 μEq/120min) responses. In AV3V-lesioned rats (1–5 days and 14–18 days), the pressor (11 ± 2 and 14 ± 2mmHg, respectively), dipsogenic (1.9 ± 0.7 and 1.4 ± 0.6ml/h), natriuretic (21 ± 5 and 159 ± 44 μEq/120min) and kaliuretic (124 ± 14 and 86 ± 13 μEq/120min) responeses induced by carbachol injection into the MSA were reduced. These results show that the AV3V region is essential for the pressor, dipsogenic, natriuretic and kaliuretic responses induced by cholinergic activation of the MSA in rats.</description><subject>Animals</subject><subject>Arterial pressure</subject><subject>AV3V region</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Carbachol - pharmacology</subject><subject>Cerebral Ventricles - physiology</subject><subject>Electrolyte balance</subject><subject>Fluid balance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Natriuresis - drug effects</subject><subject>Potassium - urine</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Septal area</subject><subject>Septum Pellucidum - drug effects</subject><subject>Thirst - drug effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Water and mineral metabolism. Osmoregulation. Acidobasic balance</subject><subject>Water intake</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6DRRyEFGwNUl30unLwrL4D3bxonsNmaR6N9KTtKn0gge_u-mZYb3pqaqoXz2K9wh5ztk7zrh6zxhTjR6G9vUg3gysU6q5ekA2XPeiUaJjD8nmHnlMniD-qGPbDuyEnHDFueR8Q36fX7fXdAIMKVJc5jkDIiAtt0D3fcpvqQ8zphuIwVEbPY225LBkKHWuyJzi_iJRd5umECHfrKAr4c6WVTaNezmEudiJ2gyWhkizLfiUPBrthPDsWE_J948fvl18bi6_fvpycX7ZuI73pbF6W98dtsJJ1TnveskH7TrlQYDwUti-tk5z3wqhtBi3vh25HMHqkcHAWXtKXh1055x-LoDF7AI6mCYbIS1o-paxXsn2v2D1TUspVsXuALqcEDOMZs5hZ_Mvw5lZ4zGr92b13gzC7OMxV_XsxVF_2e7A_z065FH3L497i85OY7bRBbzHJO-5VqJiZwcMqml3AbJBFyA68CGDK8an8O8__gDfYq2k</recordid><startdate>19920214</startdate><enddate>19920214</enddate><creator>Colombari, Eduardo</creator><creator>Abra˜o Saad, Wilson</creator><creator>de Arruda Camargo, Luiz Antonio</creator><creator>Renzi, Antonio</creator><creator>De Luca, Laurival Antonio</creator><creator>Vanderlei Menani, José</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920214</creationdate><title>AV3V lesion suppresses the pressor, dipsogenic and natriuretic responses to cholinergic activation of the septal area in rats</title><author>Colombari, Eduardo ; Abra˜o Saad, Wilson ; de Arruda Camargo, Luiz Antonio ; Renzi, Antonio ; De Luca, Laurival Antonio ; Vanderlei Menani, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a8b1159b2c564cdc75198c46de2e2d52a76dec81d322682fbd3f15fea8f0e9103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Arterial pressure</topic><topic>AV3V region</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Carbachol - pharmacology</topic><topic>Cerebral Ventricles - physiology</topic><topic>Electrolyte balance</topic><topic>Fluid balance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Hypothalamus</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Natriuresis - drug effects</topic><topic>Potassium - urine</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Septal area</topic><topic>Septum Pellucidum - drug effects</topic><topic>Thirst - drug effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Water and mineral metabolism. Osmoregulation. Acidobasic balance</topic><topic>Water intake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colombari, Eduardo</creatorcontrib><creatorcontrib>Abra˜o Saad, Wilson</creatorcontrib><creatorcontrib>de Arruda Camargo, Luiz Antonio</creatorcontrib><creatorcontrib>Renzi, Antonio</creatorcontrib><creatorcontrib>De Luca, Laurival Antonio</creatorcontrib><creatorcontrib>Vanderlei Menani, José</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colombari, Eduardo</au><au>Abra˜o Saad, Wilson</au><au>de Arruda Camargo, Luiz Antonio</au><au>Renzi, Antonio</au><au>De Luca, Laurival Antonio</au><au>Vanderlei Menani, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AV3V lesion suppresses the pressor, dipsogenic and natriuretic responses to cholinergic activation of the septal area in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1992-02-14</date><risdate>1992</risdate><volume>572</volume><issue>1</issue><spage>172</spage><epage>175</epage><pages>172-175</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>In the present study we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, dipsogenic, natriuretic and kaliuretic responses induced by the injection of carbachol (a cholinergic agonist) into the medial septal area (MSA) of rats. Male rats with sham or AV3V lesion and a stainless-steel cannula implanted into the MSA were used. Carbachol (2 nmol) injected into the MSA in sham lesion rats produced pressor (43 ± 2mmHg), dipsogenic (9.6 ± 1.2ml/h), natriuretic (531 ± 82 μEq/120min) and kaliuretic (164 ± 14 μEq/120min) responses. In AV3V-lesioned rats (1–5 days and 14–18 days), the pressor (11 ± 2 and 14 ± 2mmHg, respectively), dipsogenic (1.9 ± 0.7 and 1.4 ± 0.6ml/h), natriuretic (21 ± 5 and 159 ± 44 μEq/120min) and kaliuretic (124 ± 14 and 86 ± 13 μEq/120min) responeses induced by carbachol injection into the MSA were reduced. These results show that the AV3V region is essential for the pressor, dipsogenic, natriuretic and kaliuretic responses induced by cholinergic activation of the MSA in rats.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1611511</pmid><doi>10.1016/0006-8993(92)90466-M</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Arterial pressure AV3V region Biological and medical sciences Blood Pressure - drug effects Carbachol - pharmacology Cerebral Ventricles - physiology Electrolyte balance Fluid balance Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hypothalamus Male Metabolisms and neurohumoral controls Natriuresis - drug effects Potassium - urine Rats Rats, Inbred Strains Receptors, Cholinergic - drug effects Septal area Septum Pellucidum - drug effects Thirst - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance Water intake |
| title | AV3V lesion suppresses the pressor, dipsogenic and natriuretic responses to cholinergic activation of the septal area in rats |
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