$Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy$

Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy

The availability of an intravenous formulation now makes possible rapid administration of valproate (VPA) loading doses, but estimates of key VPA pharmacokinetic parameters in patients have limited the use of this approach. VPA disposition was characterized in 112 epilepsy patients, with or without...

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Veröffentlicht in:	Epilepsy research 2003-02, Vol.53 (1), p.19-27
Hauptverfasser:	Cloyd, James C, Dutta, Sandeep, Cao, Guoliang, Walch, Julia K, Collins, Stephen D, Granneman, G.Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Algorithms Anticonvulsants - administration & dosage Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Child Child, Preschool Concentration Dose-Response Relationship, Drug Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Female Fluorescence Polarization Immunoassay Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Infant Infusions, Intravenous Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacokinetics Pharmacology. Drug treatments Prospective Studies Protein Binding Tissue Distribution Valproate Valproic Acid - administration & dosage Valproic Acid - pharmacokinetics Valproic Acid - therapeutic use
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