Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa
Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredodegenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expression...
Gespeichert in:
| Veröffentlicht in: | Clinical immunology and immunopathology 1992-07, Vol.64 (1), p.78-83 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83 |
|---|---|
| container_issue | 1 |
| container_start_page | 78 |
| container_title | Clinical immunology and immunopathology |
| container_volume | 64 |
| creator | Williams, Lowell L. Shannon, Barry T. Chambers, Robert B. Leguire, Lawrence E. Davidorf, Frederick H. |
| description | Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredodegenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expressions over prelaser values and controls were found with a normalization of soluble interleukin-2 receptor secretion after laser treatment. Serum interferon-γ was low both pre- and postlaser. Interestingly, when a panel of viral antibodies was tested, only those to rubella virus were elevated in the early postlaser period. The character of RP immunostimulation after laser-induced inflammation could be consistent with an antigenic stimulus from laser-released retinal proteins which might be of autoimmune or latent infectious origin. Enhanced immune responses may be a common but unrecognized sequellae of retinal laser. |
| doi_str_mv | 10.1016/0090-1229(92)90062-S |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73006653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>009012299290062S</els_id><sourcerecordid>73006653</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-649964af3b9ba7c5f542f6e7ab04eb368a8a1a46989f914a6a553dc7d10f92953</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo6_rxDxR6ENFDNWmTdHMRZPELBIXVc5imE4n0Y01SwX9vaxe9eQqZ95mZ5CHkiNELRpm8pFTRlGWZOlPZuaJUZulqi8zZWM5yzrbJ_BfZJXshvNMB4rSYkRmTVBZCzMnz6itEbJxJXNP0bReia_oaouvaBGxEn3iMroU6qSEMt-gRYoNtTFw7RS66kKzd21jsAhyQHQt1wMPNuU9eb29elvfp49Pdw_L6MTU8L2IquVKSg81LVUJhhBU8sxILKCnHMpcLWAADLtVCWcU4SBAir0xRMWpVpkS-T06nuWvfffQYom5cMFjX0GLXB13kw2elyAeQT6DxXQgerV5714D_0ozqUaQeLenRklaZ_hGpV0Pb8WZ-XzZY_TVN5ob8ZJNDMFBbD61x4RcTnDOxGLdfTRgOLj4deh2Mw9Zg5TyaqKvO_f-Ob0KgkB4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73006653</pqid></control><display><type>article</type><title>Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Williams, Lowell L. ; Shannon, Barry T. ; Chambers, Robert B. ; Leguire, Lawrence E. ; Davidorf, Frederick H.</creator><creatorcontrib>Williams, Lowell L. ; Shannon, Barry T. ; Chambers, Robert B. ; Leguire, Lawrence E. ; Davidorf, Frederick H.</creatorcontrib><description>Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredodegenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expressions over prelaser values and controls were found with a normalization of soluble interleukin-2 receptor secretion after laser treatment. Serum interferon-γ was low both pre- and postlaser. Interestingly, when a panel of viral antibodies was tested, only those to rubella virus were elevated in the early postlaser period. The character of RP immunostimulation after laser-induced inflammation could be consistent with an antigenic stimulus from laser-released retinal proteins which might be of autoimmune or latent infectious origin. Enhanced immune responses may be a common but unrecognized sequellae of retinal laser.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(92)90062-S</identifier><identifier>PMID: 1606755</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Antibodies, Viral - metabolism ; Antibody Formation ; Antigens, Differentiation - metabolism ; Biological and medical sciences ; Flow Cytometry ; Humans ; Immunity, Cellular ; Interferon-gamma - metabolism ; Lasers ; Leukocyte Count ; Light Coagulation ; Medical sciences ; Middle Aged ; Ophthalmology ; Receptors, Interleukin-2 - chemistry ; Receptors, Interleukin-2 - metabolism ; Retinitis Pigmentosa - genetics ; Retinitis Pigmentosa - immunology ; Retinitis Pigmentosa - therapy ; Retinopathies ; Solubility</subject><ispartof>Clinical immunology and immunopathology, 1992-07, Vol.64 (1), p.78-83</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-649964af3b9ba7c5f542f6e7ab04eb368a8a1a46989f914a6a553dc7d10f92953</citedby><cites>FETCH-LOGICAL-c437t-649964af3b9ba7c5f542f6e7ab04eb368a8a1a46989f914a6a553dc7d10f92953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5441583$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1606755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Lowell L.</creatorcontrib><creatorcontrib>Shannon, Barry T.</creatorcontrib><creatorcontrib>Chambers, Robert B.</creatorcontrib><creatorcontrib>Leguire, Lawrence E.</creatorcontrib><creatorcontrib>Davidorf, Frederick H.</creatorcontrib><title>Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredodegenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expressions over prelaser values and controls were found with a normalization of soluble interleukin-2 receptor secretion after laser treatment. Serum interferon-γ was low both pre- and postlaser. Interestingly, when a panel of viral antibodies was tested, only those to rubella virus were elevated in the early postlaser period. The character of RP immunostimulation after laser-induced inflammation could be consistent with an antigenic stimulus from laser-released retinal proteins which might be of autoimmune or latent infectious origin. Enhanced immune responses may be a common but unrecognized sequellae of retinal laser.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Viral - metabolism</subject><subject>Antibody Formation</subject><subject>Antigens, Differentiation - metabolism</subject><subject>Biological and medical sciences</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Interferon-gamma - metabolism</subject><subject>Lasers</subject><subject>Leukocyte Count</subject><subject>Light Coagulation</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Receptors, Interleukin-2 - chemistry</subject><subject>Receptors, Interleukin-2 - metabolism</subject><subject>Retinitis Pigmentosa - genetics</subject><subject>Retinitis Pigmentosa - immunology</subject><subject>Retinitis Pigmentosa - therapy</subject><subject>Retinopathies</subject><subject>Solubility</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo6_rxDxR6ENFDNWmTdHMRZPELBIXVc5imE4n0Y01SwX9vaxe9eQqZ95mZ5CHkiNELRpm8pFTRlGWZOlPZuaJUZulqi8zZWM5yzrbJ_BfZJXshvNMB4rSYkRmTVBZCzMnz6itEbJxJXNP0bReia_oaouvaBGxEn3iMroU6qSEMt-gRYoNtTFw7RS66kKzd21jsAhyQHQt1wMPNuU9eb29elvfp49Pdw_L6MTU8L2IquVKSg81LVUJhhBU8sxILKCnHMpcLWAADLtVCWcU4SBAir0xRMWpVpkS-T06nuWvfffQYom5cMFjX0GLXB13kw2elyAeQT6DxXQgerV5714D_0ozqUaQeLenRklaZ_hGpV0Pb8WZ-XzZY_TVN5ob8ZJNDMFBbD61x4RcTnDOxGLdfTRgOLj4deh2Mw9Zg5TyaqKvO_f-Ob0KgkB4</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Williams, Lowell L.</creator><creator>Shannon, Barry T.</creator><creator>Chambers, Robert B.</creator><creator>Leguire, Lawrence E.</creator><creator>Davidorf, Frederick H.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa</title><author>Williams, Lowell L. ; Shannon, Barry T. ; Chambers, Robert B. ; Leguire, Lawrence E. ; Davidorf, Frederick H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-649964af3b9ba7c5f542f6e7ab04eb368a8a1a46989f914a6a553dc7d10f92953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Viral - metabolism</topic><topic>Antibody Formation</topic><topic>Antigens, Differentiation - metabolism</topic><topic>Biological and medical sciences</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Interferon-gamma - metabolism</topic><topic>Lasers</topic><topic>Leukocyte Count</topic><topic>Light Coagulation</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Receptors, Interleukin-2 - chemistry</topic><topic>Receptors, Interleukin-2 - metabolism</topic><topic>Retinitis Pigmentosa - genetics</topic><topic>Retinitis Pigmentosa - immunology</topic><topic>Retinitis Pigmentosa - therapy</topic><topic>Retinopathies</topic><topic>Solubility</topic><toplevel>online_resources</toplevel><creatorcontrib>Williams, Lowell L.</creatorcontrib><creatorcontrib>Shannon, Barry T.</creatorcontrib><creatorcontrib>Chambers, Robert B.</creatorcontrib><creatorcontrib>Leguire, Lawrence E.</creatorcontrib><creatorcontrib>Davidorf, Frederick H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Lowell L.</au><au>Shannon, Barry T.</au><au>Chambers, Robert B.</au><au>Leguire, Lawrence E.</au><au>Davidorf, Frederick H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>64</volume><issue>1</issue><spage>78</spage><epage>83</epage><pages>78-83</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredodegenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expressions over prelaser values and controls were found with a normalization of soluble interleukin-2 receptor secretion after laser treatment. Serum interferon-γ was low both pre- and postlaser. Interestingly, when a panel of viral antibodies was tested, only those to rubella virus were elevated in the early postlaser period. The character of RP immunostimulation after laser-induced inflammation could be consistent with an antigenic stimulus from laser-released retinal proteins which might be of autoimmune or latent infectious origin. Enhanced immune responses may be a common but unrecognized sequellae of retinal laser.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>1606755</pmid><doi>10.1016/0090-1229(92)90062-S</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-1229 |
| ispartof | Clinical immunology and immunopathology, 1992-07, Vol.64 (1), p.78-83 |
| issn | 0090-1229 1090-2341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73006653 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antibodies, Viral - metabolism Antibody Formation Antigens, Differentiation - metabolism Biological and medical sciences Flow Cytometry Humans Immunity, Cellular Interferon-gamma - metabolism Lasers Leukocyte Count Light Coagulation Medical sciences Middle Aged Ophthalmology Receptors, Interleukin-2 - chemistry Receptors, Interleukin-2 - metabolism Retinitis Pigmentosa - genetics Retinitis Pigmentosa - immunology Retinitis Pigmentosa - therapy Retinopathies Solubility |
| title | Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A21%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systemic%20immunostimulation%20after%20retinal%20laser%20treatment%20in%20retinitis%20pigmentosa&rft.jtitle=Clinical%20immunology%20and%20immunopathology&rft.au=Williams,%20Lowell%20L.&rft.date=1992-07-01&rft.volume=64&rft.issue=1&rft.spage=78&rft.epage=83&rft.pages=78-83&rft.issn=0090-1229&rft.eissn=1090-2341&rft.coden=CLIIAT&rft_id=info:doi/10.1016/0090-1229(92)90062-S&rft_dat=%3Cproquest_cross%3E73006653%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73006653&rft_id=info:pmid/1606755&rft_els_id=009012299290062S&rfr_iscdi=true |