Competitive Reactions of Interstrand and Intrastrand DNA-Pt Adducts: A Dinuclear-Platinum Complex Preferentially Forms a 1,4-Interstrand Cross-Link Rather than a 1,2 Intrastrand Cross-link on Binding to a GG 14-Mer Duplex

A study of the kinetics and mechanism of the reaction between the dinuclear Pt complex [{trans‐PtCl(NH3)2}2(μ‐NH2(CH2)6NH2)]2+ (1) and the 14‐mer duplex 5′‐d(ATACATG(7)G(8)TACATA)‐3′⋅5′‐d(TATG(25)TACCATG(18)TAT)‐3′ is reported. [1H,15N]‐HSQC NMR was used to follow the reaction at 298 K, pH 5.4. The...

Ausführliche Beschreibung