Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells
Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotranspla...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1992-06, Vol.185 (2), p.577-581 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Ishizuka, Jin Beauchamp, R.Daniel Evers, B.Mark Townsend, Courtney M. Thompson, James C. |
| description | Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial.
In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit
in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells. |
| doi_str_mv | 10.1016/0006-291X(92)91663-B |
| format | Article |
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In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit
in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(92)91663-B</identifier><identifier>PMID: 1351720</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Carcinoid Tumor - drug therapy ; Cell Division - drug effects ; Cyclic AMP - metabolism ; General aspects ; Growth Substances - pharmacology ; Humans ; In Vitro Techniques ; Medical sciences ; Octreotide - pharmacology ; Pharmacology. Drug treatments ; Phosphatidylinositols - metabolism ; Somatostatin - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Biochemical and biophysical research communications, 1992-06, Vol.185 (2), p.577-581</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6cd88e44aa134969a004dd25d937e6be68d83c0e2a22449f5f454cb9951face93</citedby><cites>FETCH-LOGICAL-c386t-6cd88e44aa134969a004dd25d937e6be68d83c0e2a22449f5f454cb9951face93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(92)91663-B$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5347842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1351720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishizuka, Jin</creatorcontrib><creatorcontrib>Beauchamp, R.Daniel</creatorcontrib><creatorcontrib>Evers, B.Mark</creatorcontrib><creatorcontrib>Townsend, Courtney M.</creatorcontrib><creatorcontrib>Thompson, James C.</creatorcontrib><title>Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial.
In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit
in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Carcinoid Tumor - drug therapy</subject><subject>Cell Division - drug effects</subject><subject>Cyclic AMP - metabolism</subject><subject>General aspects</subject><subject>Growth Substances - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Octreotide - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylinositols - metabolism</subject><subject>Somatostatin - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LXDEUhkNpsVPbf9BCFkXq4rb5upmbjaBibUFwo9BdyCQnGrk3mSa5Vv-9mc6gO1cHzvu8h8OD0GdKvlNC5Q9CiOyYon--KXaoqJS8O3mDFpQo0jFKxFu0eEbeow-l3BFCqZBqD-1R3tMlIwt0dx3hYQ22gsM3Of2rt12pYZpHU1N-xOB9y3DyuKSprUo1NURsohnTzQw4RWznsc651W_nyUS8NtFmaJTF1mQbYgoOWxjH8hG982Ys8Gk399H1z7Or01_dxeX579Pji87yQdZOWjcMIIQxlAsllSFEOMd6p_gS5Ark4AZuCTDDmBDK9170wq6U6qk3FhTfRwfbu-uc_s5Qqp5C2XxgIqS56CVvVlq1gWIL2pxKyeD1OofJ5EdNid4o1ht_euNPK6b_K9YnrfZld39eTeBeSlunLf-6y02xZvS5GQnlGeu5WA6CNexoi0FzcR8g62IDRAsu5OZcuxRe_-MJgCGaQA</recordid><startdate>19920615</startdate><enddate>19920615</enddate><creator>Ishizuka, Jin</creator><creator>Beauchamp, R.Daniel</creator><creator>Evers, B.Mark</creator><creator>Townsend, Courtney M.</creator><creator>Thompson, James C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920615</creationdate><title>Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells</title><author>Ishizuka, Jin ; Beauchamp, R.Daniel ; Evers, B.Mark ; Townsend, Courtney M. ; Thompson, James C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6cd88e44aa134969a004dd25d937e6be68d83c0e2a22449f5f454cb9951face93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Carcinoid Tumor - drug therapy</topic><topic>Cell Division - drug effects</topic><topic>Cyclic AMP - metabolism</topic><topic>General aspects</topic><topic>Growth Substances - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Octreotide - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylinositols - metabolism</topic><topic>Somatostatin - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishizuka, Jin</creatorcontrib><creatorcontrib>Beauchamp, R.Daniel</creatorcontrib><creatorcontrib>Evers, B.Mark</creatorcontrib><creatorcontrib>Townsend, Courtney M.</creatorcontrib><creatorcontrib>Thompson, James C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishizuka, Jin</au><au>Beauchamp, R.Daniel</au><au>Evers, B.Mark</au><au>Townsend, Courtney M.</au><au>Thompson, James C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1992-06-15</date><risdate>1992</risdate><volume>185</volume><issue>2</issue><spage>577</spage><epage>581</epage><pages>577-581</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial.
In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit
in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1351720</pmid><doi>10.1016/0006-291X(92)91663-B</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic agents Biological and medical sciences Carcinoid Tumor - drug therapy Cell Division - drug effects Cyclic AMP - metabolism General aspects Growth Substances - pharmacology Humans In Vitro Techniques Medical sciences Octreotide - pharmacology Pharmacology. Drug treatments Phosphatidylinositols - metabolism Somatostatin - pharmacology Tumor Cells, Cultured |
| title | Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells |
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