Appearance of prolactin-releasing peptide-producing neurons in the area postrema of adrenalectomized rats
Prolactin-releasing peptide (PrRP) was found to be a novel hypothalamic peptide that stimulates prolactin release in vitro and in vivo. In the normal adult rat brain, PrRP neurons are known to be located in only three areas, i.e. the dorsomedial hypothalamic nucleus, ventrolateral reticular formatio...
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| Veröffentlicht in: | Neuroscience letters 2003-02, Vol.338 (2), p.127-130 |
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| creator | Fujiwara, Ken Maruyama, Minoru Usui, Kimie Sakai, Takafumi Matsumoto, Hirokazu Hinuma, Shuji Kitada, Chieko Inoue, Kinji |
| description | Prolactin-releasing peptide (PrRP) was found to be a novel hypothalamic peptide that stimulates prolactin release in vitro and in vivo. In the normal adult rat brain, PrRP neurons are known to be located in only three areas, i.e. the dorsomedial hypothalamic nucleus, ventrolateral reticular formation; and nucleus of the tractus solitarius in the medulla oblongata. These PrRP neurons project neurites into various brain areas, including regions such as the paraventricular nucleus, supraoptic nucleus, and bed nucleus of the stria terminalis. Both PrRP nerve fibers and a high level of PrRP receptor, UHR-1, mRNA are observed in the area postrema (AP),but no PrRP neurons are detected in the AP of normal rats. In this study, we clearly demonstrated that PrRP-producing cells newly appeared in the AP of adrenalectomized rats by in situ hybridization and immunocytochemistry. Our results suggest that PrRP may have some important roles in the AP of adrenalectomized rats. This is the first report demonstrating the appearance of PrRP-positive cells in the AP. |
| doi_str_mv | 10.1016/S0304-3940(02)01395-2 |
| format | Article |
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In the normal adult rat brain, PrRP neurons are known to be located in only three areas, i.e. the dorsomedial hypothalamic nucleus, ventrolateral reticular formation; and nucleus of the tractus solitarius in the medulla oblongata. These PrRP neurons project neurites into various brain areas, including regions such as the paraventricular nucleus, supraoptic nucleus, and bed nucleus of the stria terminalis. Both PrRP nerve fibers and a high level of PrRP receptor, UHR-1, mRNA are observed in the area postrema (AP),but no PrRP neurons are detected in the AP of normal rats. In this study, we clearly demonstrated that PrRP-producing cells newly appeared in the AP of adrenalectomized rats by in situ hybridization and immunocytochemistry. Our results suggest that PrRP may have some important roles in the AP of adrenalectomized rats. This is the first report demonstrating the appearance of PrRP-positive cells in the AP.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)01395-2</identifier><identifier>PMID: 12566169</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adrenalectomy ; Animals ; Area postrema ; Area Postrema - metabolism ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions ; Hypothalamic Hormones - metabolism ; Immunocytochemistry ; Immunohistochemistry ; In Situ Hybridization ; Neurons - metabolism ; Neuropeptides - metabolism ; Prolactin - metabolism ; Prolactin-Releasing Hormone ; Prolactin-releasing peptide ; Rat ; Rats ; Rats, Wistar ; RNA, Messenger - metabolism ; Vertebrates: endocrinology</subject><ispartof>Neuroscience letters, 2003-02, Vol.338 (2), p.127-130</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-621ebcd91c98b3b8e6eccf42a26774a9bc2eac8010efc9152eb725eaf50d63403</citedby><cites>FETCH-LOGICAL-c457t-621ebcd91c98b3b8e6eccf42a26774a9bc2eac8010efc9152eb725eaf50d63403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394002013952$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14496663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12566169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujiwara, Ken</creatorcontrib><creatorcontrib>Maruyama, Minoru</creatorcontrib><creatorcontrib>Usui, Kimie</creatorcontrib><creatorcontrib>Sakai, Takafumi</creatorcontrib><creatorcontrib>Matsumoto, Hirokazu</creatorcontrib><creatorcontrib>Hinuma, Shuji</creatorcontrib><creatorcontrib>Kitada, Chieko</creatorcontrib><creatorcontrib>Inoue, Kinji</creatorcontrib><title>Appearance of prolactin-releasing peptide-producing neurons in the area postrema of adrenalectomized rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Prolactin-releasing peptide (PrRP) was found to be a novel hypothalamic peptide that stimulates prolactin release in vitro and in vivo. In the normal adult rat brain, PrRP neurons are known to be located in only three areas, i.e. the dorsomedial hypothalamic nucleus, ventrolateral reticular formation; and nucleus of the tractus solitarius in the medulla oblongata. These PrRP neurons project neurites into various brain areas, including regions such as the paraventricular nucleus, supraoptic nucleus, and bed nucleus of the stria terminalis. Both PrRP nerve fibers and a high level of PrRP receptor, UHR-1, mRNA are observed in the area postrema (AP),but no PrRP neurons are detected in the AP of normal rats. In this study, we clearly demonstrated that PrRP-producing cells newly appeared in the AP of adrenalectomized rats by in situ hybridization and immunocytochemistry. Our results suggest that PrRP may have some important roles in the AP of adrenalectomized rats. This is the first report demonstrating the appearance of PrRP-positive cells in the AP.</description><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Area postrema</subject><subject>Area Postrema - metabolism</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions</subject><subject>Hypothalamic Hormones - metabolism</subject><subject>Immunocytochemistry</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Neurons - metabolism</subject><subject>Neuropeptides - metabolism</subject><subject>Prolactin - metabolism</subject><subject>Prolactin-Releasing Hormone</subject><subject>Prolactin-releasing peptide</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctO3TAQQK2qVblAP6Eom1Z0ETp2bOd6hRBqSyUkFpS1NbEn4Cov7ASpfH0d7lVZdjXSzJmHzjD2kcMZB66_3kIFsqyMhFMQX4BXRpXiDdvwbS3K2tTiLdv8Qw7YYUq_AUBxJd-zAy6U1lybDQsX00QYcXBUjG0xxbFDN4ehjNQRpjDcFxNNc_BU5ppf3JoZaInjkIowFPMDFRgJi2lMc6Qe1ynoIw3YkZvHPjyTLyLO6Zi9a7FL9GEfj9jd92-_Lq_K65sfPy8vrksnVT2XWnBqnDfcmW1TNVvS5FwrBQpd1xJN4wSh2wIHap3hSlBTC0XYKvC6klAdsc-7ufnex4XSbPuQHHUdDjQuydYVgOZcZVDtQBfHlCK1doqhx_jHcrCrY_vi2K4CLQj74tiK3HeyX7A0PfnXrr3UDHzaA5gcdu1qN6RXTkqjta4yd77jKOt4ChRtcoHyJ3yI2Z31Y_jPKX8BY_qa0Q</recordid><startdate>20030227</startdate><enddate>20030227</enddate><creator>Fujiwara, Ken</creator><creator>Maruyama, Minoru</creator><creator>Usui, Kimie</creator><creator>Sakai, Takafumi</creator><creator>Matsumoto, Hirokazu</creator><creator>Hinuma, Shuji</creator><creator>Kitada, Chieko</creator><creator>Inoue, Kinji</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030227</creationdate><title>Appearance of prolactin-releasing peptide-producing neurons in the area postrema of adrenalectomized rats</title><author>Fujiwara, Ken ; Maruyama, Minoru ; Usui, Kimie ; Sakai, Takafumi ; Matsumoto, Hirokazu ; Hinuma, Shuji ; Kitada, Chieko ; Inoue, Kinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-621ebcd91c98b3b8e6eccf42a26774a9bc2eac8010efc9152eb725eaf50d63403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Area postrema</topic><topic>Area Postrema - metabolism</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions</topic><topic>Hypothalamic Hormones - metabolism</topic><topic>Immunocytochemistry</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Neurons - metabolism</topic><topic>Neuropeptides - metabolism</topic><topic>Prolactin - metabolism</topic><topic>Prolactin-Releasing Hormone</topic><topic>Prolactin-releasing peptide</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujiwara, Ken</creatorcontrib><creatorcontrib>Maruyama, Minoru</creatorcontrib><creatorcontrib>Usui, Kimie</creatorcontrib><creatorcontrib>Sakai, Takafumi</creatorcontrib><creatorcontrib>Matsumoto, Hirokazu</creatorcontrib><creatorcontrib>Hinuma, Shuji</creatorcontrib><creatorcontrib>Kitada, Chieko</creatorcontrib><creatorcontrib>Inoue, Kinji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujiwara, Ken</au><au>Maruyama, Minoru</au><au>Usui, Kimie</au><au>Sakai, Takafumi</au><au>Matsumoto, Hirokazu</au><au>Hinuma, Shuji</au><au>Kitada, Chieko</au><au>Inoue, Kinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Appearance of prolactin-releasing peptide-producing neurons in the area postrema of adrenalectomized rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2003-02-27</date><risdate>2003</risdate><volume>338</volume><issue>2</issue><spage>127</spage><epage>130</epage><pages>127-130</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Prolactin-releasing peptide (PrRP) was found to be a novel hypothalamic peptide that stimulates prolactin release in vitro and in vivo. In the normal adult rat brain, PrRP neurons are known to be located in only three areas, i.e. the dorsomedial hypothalamic nucleus, ventrolateral reticular formation; and nucleus of the tractus solitarius in the medulla oblongata. These PrRP neurons project neurites into various brain areas, including regions such as the paraventricular nucleus, supraoptic nucleus, and bed nucleus of the stria terminalis. Both PrRP nerve fibers and a high level of PrRP receptor, UHR-1, mRNA are observed in the area postrema (AP),but no PrRP neurons are detected in the AP of normal rats. In this study, we clearly demonstrated that PrRP-producing cells newly appeared in the AP of adrenalectomized rats by in situ hybridization and immunocytochemistry. Our results suggest that PrRP may have some important roles in the AP of adrenalectomized rats. This is the first report demonstrating the appearance of PrRP-positive cells in the AP.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12566169</pmid><doi>10.1016/S0304-3940(02)01395-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2003-02, Vol.338 (2), p.127-130 |
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| subjects | Adrenalectomy Animals Area postrema Area Postrema - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Hypothalamic Hormones - metabolism Immunocytochemistry Immunohistochemistry In Situ Hybridization Neurons - metabolism Neuropeptides - metabolism Prolactin - metabolism Prolactin-Releasing Hormone Prolactin-releasing peptide Rat Rats Rats, Wistar RNA, Messenger - metabolism Vertebrates: endocrinology |
| title | Appearance of prolactin-releasing peptide-producing neurons in the area postrema of adrenalectomized rats |
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