Reconstitution of (BALB/c x B6)F1 normal mice with stem cells and thymus from nonobese diabetic mice results in autoimmune insulitis of the normal hosts' pancreases
The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we cons...
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| Veröffentlicht in: | Transplantation 1992-06, Vol.53 (6), p.1347-1352 |
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| container_title | Transplantation |
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| creator | STEIN, P. H REES, M. A SINGER, A |
| description | The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that had an NOD immune system and a non-NOD host pancreas. We found that these animals with only an NOD immune system developed both insulitis and diabetes in their non-NOD pancreas. We conclude that the NOD pancreas is not unique in its ability to elicit an autoimmune attack from NOD T cells. |
| doi_str_mv | 10.1097/00007890-199206000-00032 |
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We conclude that the NOD pancreas is not unique in its ability to elicit an autoimmune attack from NOD T cells.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199206000-00032</identifier><identifier>PMID: 1604490</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Autoimmune Diseases - etiology ; Biological and medical sciences ; Experimental and animal immunopathology. Animal models ; Female ; Immunopathology ; Immunotherapy, Adoptive ; Islets of Langerhans - cytology ; Islets of Langerhans - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Pancreatitis - immunology ; Stem Cells ; Thymus Gland - cytology</subject><ispartof>Transplantation, 1992-06, Vol.53 (6), p.1347-1352</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-4dafa2023a7d7015bcba4143aa5bcaa07ddaa5ae39f1f577acb91cf744b7b4403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5381995$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1604490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STEIN, P. 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We conclude that the NOD pancreas is not unique in its ability to elicit an autoimmune attack from NOD T cells.</description><subject>Animals</subject><subject>Autoimmune Diseases - etiology</subject><subject>Biological and medical sciences</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Female</subject><subject>Immunopathology</subject><subject>Immunotherapy, Adoptive</subject><subject>Islets of Langerhans - cytology</subject><subject>Islets of Langerhans - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Pancreatitis - immunology</subject><subject>Stem Cells</subject><subject>Thymus Gland - cytology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUdtu1DAQtRBVWQqfgOQHxOUh1I6dePPYrSggrVQJwXM0cSZao9hePI6g_9MPxctuW0sjz3jOmSPPYYxL8UmKzlyKcsy6E5Xsulq0papKqPoZW8lG6aoVa_GcrYTQspJKmRfsJdGvAmmUMefsXLZC606s2P13tDFQdnnJLgYeJ_5hc7XdXFr-l2_ajzeSh5g8zNw7i_yPyztOGT23OM_EIYw87-78QnxK0RdsiAMS8tHBgNnZIy0hLXMm7gKHJUfn_RKwVOXVZUcH1bzDB6VdpEzv-R6CTQiE9IqdTTATvj7dF-znzecf11-r7e2Xb9dX28qqWuZKjzBBLWoFZjRCNoMdQEutAEoKIMw4lhRQdZOcGmPADp20k9F6MIPWQl2wd8e5-xR_L0i5944OH4WAcaHeqLLArm4LcH0E2hSJEk79PjkP6a6Xoj8Y1D8Y1D8a1P83qFDfnDSWweP4RDw6UvpvT30gC_OUyhYcPcIatS4TG_UPXpebHA</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>STEIN, P. 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A ; SINGER, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-4dafa2023a7d7015bcba4143aa5bcaa07ddaa5ae39f1f577acb91cf744b7b4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Autoimmune Diseases - etiology</topic><topic>Biological and medical sciences</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Female</topic><topic>Immunopathology</topic><topic>Immunotherapy, Adoptive</topic><topic>Islets of Langerhans - cytology</topic><topic>Islets of Langerhans - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Pancreatitis - immunology</topic><topic>Stem Cells</topic><topic>Thymus Gland - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STEIN, P. H</creatorcontrib><creatorcontrib>REES, M. A</creatorcontrib><creatorcontrib>SINGER, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STEIN, P. H</au><au>REES, M. A</au><au>SINGER, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reconstitution of (BALB/c x B6)F1 normal mice with stem cells and thymus from nonobese diabetic mice results in autoimmune insulitis of the normal hosts' pancreases</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>53</volume><issue>6</issue><spage>1347</spage><epage>1352</epage><pages>1347-1352</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that had an NOD immune system and a non-NOD host pancreas. We found that these animals with only an NOD immune system developed both insulitis and diabetes in their non-NOD pancreas. We conclude that the NOD pancreas is not unique in its ability to elicit an autoimmune attack from NOD T cells.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>1604490</pmid><doi>10.1097/00007890-199206000-00032</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1992-06, Vol.53 (6), p.1347-1352 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Autoimmune Diseases - etiology Biological and medical sciences Experimental and animal immunopathology. Animal models Female Immunopathology Immunotherapy, Adoptive Islets of Langerhans - cytology Islets of Langerhans - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Pancreatitis - immunology Stem Cells Thymus Gland - cytology |
| title | Reconstitution of (BALB/c x B6)F1 normal mice with stem cells and thymus from nonobese diabetic mice results in autoimmune insulitis of the normal hosts' pancreases |
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