DPI induces mitochondrial superoxide-mediated apoptosis

The iodonium compounds diphenyleneiodonium (DPI) and diphenyliodonium (IDP) are well-known phagocyte NAD(P)H oxidase inhibitors. However, it has been shown that at high concentrations they can inhibit the mitochondrial respiratory chain as well. Since inhibition of the mitochondrial respiratory chai...

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Veröffentlicht in:	Free radical biology & medicine 2003-02, Vol.34 (4), p.465-477
Hauptverfasser:	Li, Nianyu, Ragheb, Kathy, Lawler, Gretchen, Sturgis, Jennie, Rajwa, Bartek, Melendez, J.Andres, Robinson, J.Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Caspase 3 Caspases - metabolism Cytochrome c Group - metabolism Diphenyleneiodonium DNA Fragmentation Enzyme Activation - drug effects Fibrosarcoma Free radicals Gene Expression HL-60 Cells Humans Hydroethidine JC-1 Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Mitochondria, Heart - ultrastructure Mitochondrion MnSOD Myocardium - ultrastructure Onium Compounds - pharmacology Rats Reactive oxygen species Submitochondrial Particles - metabolism Superoxide Dismutase - genetics Superoxides - metabolism Superoxides - pharmacology Tumor Cells, Cultured
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