Effects of partial nephrectomy on the pharmacokinetics and pharmacodynamics of recombinant human erythropoietin (SNB-5001) in rats

The present study examined the pharmacokinetic and pharmacodynamic profiles of recombinant human erythropoietin (SNB-5001) in partially nephrectomized rats. The plasma level of SNB-5001 was measured by a 2-step enzyme immunoassay. The plasma disappearance curve after intravenous injection of SNB-500...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1992, Vol.99(4), pp.205-211
Hauptverfasser:	MASUNAGA, Hiroaki, TAKAHIRA, Reiko, KOHSAKA, Kazuhiro, SAWAI, Tadanori
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Dose-Response Relationship, Drug Erythropoietin - pharmacokinetics Erythropoietin - pharmacology Half-Life Hematopoiesis - drug effects Kidney - metabolism Male Nephrectomy Rats Rats, Inbred Strains Recombinant Proteins - pharmacokinetics Recombinant Proteins - pharmacology Uremia - metabolism
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