Comparative In Vitro Study of a Series of Organic Nitroesters: Unique Biphasic Concentration-Effect Curves for Glyceryl Trinitrate in Isolated Bovine Arterial Smooth Muscle and Lack of Stereoselectivity for Some Glyceryl Trinitrate Analogues

SummaryFour different organic nitroesters, constituting a homologous series based on unbranched polyalcohols, were compared with regard to in vitro relaxation of isolated bovine mesenteric arteries contracted with 2.5 μM phenylephrine. The organic nitroesters included ethylene glycol dinitrate (EGDN...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1992-06, Vol.19 (6), p.953-957
Hauptverfasser:	Axelsson, Krister L, Andersson, Conny, Ahlner, Johan, Magnusson, Bengt, Wikberg, Jarl E. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Cattle In Vitro Techniques Medical sciences Mesenteric Arteries - drug effects Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Nitroglycerin - analogs & derivatives Nitroglycerin - pharmacology Pharmacology. Drug treatments Stereoisomerism
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