Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP
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| Veröffentlicht in: | Molecular and Cellular Biology 2003-02, Vol.23 (4), p.1278-1291 |
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| container_title | Molecular and Cellular Biology |
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| creator | Hietakangas, Ville Poukkula, Minna Heiskanen, Kaisa M. Karvinen, Jarkko T. Sistonen, Lea Eriksson, John E. |
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| doi_str_mv | 10.1128/MCB.23.4.1278-1291.2003 |
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</description><identifier>ISSN: 0270-7306</identifier><identifier>ISSN: 1098-5549</identifier><identifier>EISSN: 1098-5549</identifier><identifier>DOI: 10.1128/MCB.23.4.1278-1291.2003</identifier><identifier>PMID: 12556488</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Alternative Splicing ; Apoptosis - physiology ; Apoptosis Regulatory Proteins ; bcl-X Protein ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein ; Caspase 8 ; Caspase 9 ; Caspases - metabolism ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell Growth and Development ; Cytochrome c Group - metabolism ; Death Domain Receptor Signaling Adaptor Proteins ; Down-Regulation ; Hemin - pharmacology ; HL-60 Cells - metabolism ; HL-60 Cells - pathology ; Humans ; Intracellular Membranes ; Intracellular Signaling Peptides and Proteins ; K562 Cells - metabolism ; K562 Cells - pathology ; Membrane Glycoproteins - metabolism ; Membrane Glycoproteins - pharmacology ; Membrane Potentials - drug effects ; Mitochondria - metabolism ; Protein Isoforms ; Proto-Oncogene Proteins c-bcl-2 - drug effects ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Receptors, Tumor Necrosis Factor - metabolism ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha - metabolism ; Tumor Necrosis Factor-alpha - pharmacology</subject><ispartof>Molecular and Cellular Biology, 2003-02, Vol.23 (4), p.1278-1291</ispartof><rights>Copyright © 2003, American Society for Microbiology 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-cc8f18d9393e2a545e7983e393ee2ccdfbdb78a0f4bd3e9ab4df83a77cef66763</citedby><cites>FETCH-LOGICAL-c563t-cc8f18d9393e2a545e7983e393ee2ccdfbdb78a0f4bd3e9ab4df83a77cef66763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC141136/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC141136/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12556488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hietakangas, Ville</creatorcontrib><creatorcontrib>Poukkula, Minna</creatorcontrib><creatorcontrib>Heiskanen, Kaisa M.</creatorcontrib><creatorcontrib>Karvinen, Jarkko T.</creatorcontrib><creatorcontrib>Sistonen, Lea</creatorcontrib><creatorcontrib>Eriksson, John E.</creatorcontrib><title>Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP</title><title>Molecular and Cellular Biology</title><addtitle>Mol Cell Biol</addtitle><description>Article Usage Stats
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</description><subject>Alternative Splicing</subject><subject>Apoptosis - physiology</subject><subject>Apoptosis Regulatory Proteins</subject><subject>bcl-X Protein</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>CASP8 and FADD-Like Apoptosis Regulating Protein</subject><subject>Caspase 8</subject><subject>Caspase 9</subject><subject>Caspases - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Growth and Development</subject><subject>Cytochrome c Group - metabolism</subject><subject>Death Domain Receptor Signaling Adaptor Proteins</subject><subject>Down-Regulation</subject><subject>Hemin - pharmacology</subject><subject>HL-60 Cells - metabolism</subject><subject>HL-60 Cells - pathology</subject><subject>Humans</subject><subject>Intracellular Membranes</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>K562 Cells - metabolism</subject><subject>K562 Cells - pathology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Glycoproteins - pharmacology</subject><subject>Membrane Potentials - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Protein Isoforms</subject><subject>Proto-Oncogene Proteins c-bcl-2 - drug effects</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Receptors, TNF-Related Apoptosis-Inducing Ligand</subject><subject>Receptors, Tumor Necrosis Factor - metabolism</subject><subject>Signal Transduction</subject><subject>TNF-Related Apoptosis-Inducing Ligand</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><issn>0270-7306</issn><issn>1098-5549</issn><issn>1098-5549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAUhS0EYsrAXwCzYZfgRx7OgkWnMwMVQSAY1pZjX7eGJC52QlV-PYlSMbBiZV35nHMfH0IvKEkpZeL1h81VyniapZSVIqGsoikjhD9AK0oqkeR5Vj1EK8JKkpScFBfoSYzfCCFFRfhjdEFZnheZECvkb8Jp2AfvDL521kKAfnBqcL7HX6CPbnC_IOL3ecFwDeN36JzCG2jbiAeP7z6vt3Wy7c2oweD1wR8GH13EzQlf-2MfYDe2S5a3WCe39fbTU_TIqjbCs_N7ib7e3txt3iX1x7fbzbpOdF7wIdFaWCpMxSsOTOVZDmUlOMwlMK2NbUxTCkVs1hgOlWoyYwVXZanBFkVZ8Ev0Zsk9jE0HRk9rBdXKQ3CdCifplZP__vRuL3f-p6QZpXz2vzr7g_8xQhxk56KeFlc9-DHK6aqEMk4mYbkIdfAxBrB_elAiZ1ZyYiUZl5mcWcmZlZxZTc7nf4947zvDmQRXi8D11odOHX1ojRzUqfXBBtVrFyX_f5eXS8je7fZHF0Cq2MlON_dq_huaCrL7</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Hietakangas, Ville</creator><creator>Poukkula, Minna</creator><creator>Heiskanen, Kaisa M.</creator><creator>Karvinen, Jarkko T.</creator><creator>Sistonen, Lea</creator><creator>Eriksson, John E.</creator><general>American Society for Microbiology</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030201</creationdate><title>Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP</title><author>Hietakangas, Ville ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>12556488</pmid><doi>10.1128/MCB.23.4.1278-1291.2003</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0270-7306 |
| ispartof | Molecular and Cellular Biology, 2003-02, Vol.23 (4), p.1278-1291 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alternative Splicing Apoptosis - physiology Apoptosis Regulatory Proteins bcl-X Protein Carrier Proteins - genetics Carrier Proteins - metabolism CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Caspase 9 Caspases - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cell Growth and Development Cytochrome c Group - metabolism Death Domain Receptor Signaling Adaptor Proteins Down-Regulation Hemin - pharmacology HL-60 Cells - metabolism HL-60 Cells - pathology Humans Intracellular Membranes Intracellular Signaling Peptides and Proteins K562 Cells - metabolism K562 Cells - pathology Membrane Glycoproteins - metabolism Membrane Glycoproteins - pharmacology Membrane Potentials - drug effects Mitochondria - metabolism Protein Isoforms Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - metabolism Signal Transduction TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology |
| title | Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP |
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