Interleukin-12 and the regulation of innate resistance and adaptive immunity

Key Points Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (T H 1) cells and is an important link between innate resistance and adapt...

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Veröffentlicht in:	Nature reviews. Immunology 2003-02, Vol.3 (2), p.133-146
1. Verfasser:	Trinchieri, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Adaptive immunity Animals Antigens Antimicrobial agents Biomedical and Life Sciences Biomedicine Cell Differentiation Chemokines Cytokines Cytotoxicity Dendritic cells Evolution, Molecular Extracellular matrix Gene Expression Regulation Humans Immunity, Innate Immunology Infection - immunology Infections Interleukin-12 - chemistry Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-23 Interleukin-23 Subunit p19 Interleukins - immunology Ligands Lymphocytes Models, Immunological Molecular Structure Neoplasms - immunology Parasites Pathogens Receptors, Interleukin - chemistry Receptors, Interleukin - genetics Receptors, Interleukin - immunology Receptors, Interleukin-12 review-article Signal Transduction Th1 Cells - cytology Th1 Cells - immunology
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