Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging
To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-s...
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| Veröffentlicht in: | Neuroscience letters 2003-02, Vol.338 (2), p.119-122 |
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| creator | Hartmann, Marius Heiland, Sabine Harting, Inga Tronnier, Volker M. Sommer, Clemens Ludwig, Roman Sartor, Klaus |
| description | To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-susceptibility contrast MR imaging the intensity-time curves of each tumor were analyzed, and we determined the relative regional cerebral blood volume ratios (rrCBV [tumor/contralateral white matter (WM)]) to find out whether these parameters could be used to separate PCNSL from GBM. The maximum rrCBV ratio in the PCNSL was significantly lower than that of the GBM (
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| doi_str_mv | 10.1016/S0304-3940(02)01367-8 |
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P<0.0001). Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space. PCNSL tend to have low maximum CBV ratios and typical intensity-time curves. These two parameters may be useful in distinguishing PCNSL from GBM.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)01367-8</identifier><identifier>PMID: 12566167</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Brain Neoplasms - blood supply ; Brain Neoplasms - diagnosis ; Brain Neoplasms - pathology ; Cerebral glioma ; Diagnosis, Differential ; Glioma - blood supply ; Glioma - diagnosis ; Glioma - pathology ; Humans ; Lymphoma ; Lymphoma - diagnosis ; Lymphoma - pathology ; Magnetic Resonance Imaging - methods ; Medical sciences ; Neurology ; Perfusion-weighted magnetic resonance imaging ; Severity of Illness Index ; Supratentorial Neoplasms - blood supply ; Supratentorial Neoplasms - diagnosis ; Supratentorial Neoplasms - pathology ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Neuroscience letters, 2003-02, Vol.338 (2), p.119-122</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-c74d14335fa72ccb053d6a80ebe8f963769cb29fbf03ebcc86e43672c7ea60da3</citedby><cites>FETCH-LOGICAL-c443t-c74d14335fa72ccb053d6a80ebe8f963769cb29fbf03ebcc86e43672c7ea60da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(02)01367-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14496661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12566167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartmann, Marius</creatorcontrib><creatorcontrib>Heiland, Sabine</creatorcontrib><creatorcontrib>Harting, Inga</creatorcontrib><creatorcontrib>Tronnier, Volker M.</creatorcontrib><creatorcontrib>Sommer, Clemens</creatorcontrib><creatorcontrib>Ludwig, Roman</creatorcontrib><creatorcontrib>Sartor, Klaus</creatorcontrib><title>Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-susceptibility contrast MR imaging the intensity-time curves of each tumor were analyzed, and we determined the relative regional cerebral blood volume ratios (rrCBV [tumor/contralateral white matter (WM)]) to find out whether these parameters could be used to separate PCNSL from GBM. The maximum rrCBV ratio in the PCNSL was significantly lower than that of the GBM (
P<0.0001). Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space. PCNSL tend to have low maximum CBV ratios and typical intensity-time curves. These two parameters may be useful in distinguishing PCNSL from GBM.</description><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - pathology</subject><subject>Cerebral glioma</subject><subject>Diagnosis, Differential</subject><subject>Glioma - blood supply</subject><subject>Glioma - diagnosis</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Lymphoma</subject><subject>Lymphoma - diagnosis</subject><subject>Lymphoma - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Perfusion-weighted magnetic resonance imaging</subject><subject>Severity of Illness Index</subject><subject>Supratentorial Neoplasms - blood supply</subject><subject>Supratentorial Neoplasms - diagnosis</subject><subject>Supratentorial Neoplasms - pathology</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3TAQRi3UqlxoHwHkTVG7CPVf7GSFEKW0ElIXbdeW44wToyS-2AmIt8eXG8Gyq08anZlvdBA6oeScEiq__SGciILXgnwh7CuhXKqiOkAbWilWqFqxd2jzihyio5TuCCElLcUHdEhZKSWVaoOW7z7NfuoWn_ocODi8jX408QlbiNBEM-Dhadz2YTTYxTDi3nd90UXTAu4Gvxs_-rnHW4huST5MxSNkYoYWj6abYPYWR0hhMpMFnC93ueYjeu_MkODTmsfo34_rv1c_i9vfN7-uLm8LKwSfC6tESwXnpTOKWduQkrfSVAQaqFwtuZK1bVjtGkc4NNZWEkT2wKwCI0lr-DE629_dxnC_QJr16JOFYTAThCVpxeq6UkpksNyDNoaUIji9WtCU6J1v_eJb72RqwvSLb13lvdO1YGlGaN-2VsEZ-LwCJlkzuJg1-PTGCVHLTGbuYs9B1vHgIepkPWRlrY9gZ90G_59XngGDh5_A</recordid><startdate>20030227</startdate><enddate>20030227</enddate><creator>Hartmann, Marius</creator><creator>Heiland, Sabine</creator><creator>Harting, Inga</creator><creator>Tronnier, Volker M.</creator><creator>Sommer, Clemens</creator><creator>Ludwig, Roman</creator><creator>Sartor, Klaus</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030227</creationdate><title>Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging</title><author>Hartmann, Marius ; Heiland, Sabine ; Harting, Inga ; Tronnier, Volker M. ; Sommer, Clemens ; Ludwig, Roman ; Sartor, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-c74d14335fa72ccb053d6a80ebe8f963769cb29fbf03ebcc86e43672c7ea60da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - blood supply</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - pathology</topic><topic>Cerebral glioma</topic><topic>Diagnosis, Differential</topic><topic>Glioma - blood supply</topic><topic>Glioma - diagnosis</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Lymphoma</topic><topic>Lymphoma - diagnosis</topic><topic>Lymphoma - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Perfusion-weighted magnetic resonance imaging</topic><topic>Severity of Illness Index</topic><topic>Supratentorial Neoplasms - blood supply</topic><topic>Supratentorial Neoplasms - diagnosis</topic><topic>Supratentorial Neoplasms - pathology</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartmann, Marius</creatorcontrib><creatorcontrib>Heiland, Sabine</creatorcontrib><creatorcontrib>Harting, Inga</creatorcontrib><creatorcontrib>Tronnier, Volker M.</creatorcontrib><creatorcontrib>Sommer, Clemens</creatorcontrib><creatorcontrib>Ludwig, Roman</creatorcontrib><creatorcontrib>Sartor, Klaus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartmann, Marius</au><au>Heiland, Sabine</au><au>Harting, Inga</au><au>Tronnier, Volker M.</au><au>Sommer, Clemens</au><au>Ludwig, Roman</au><au>Sartor, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2003-02-27</date><risdate>2003</risdate><volume>338</volume><issue>2</issue><spage>119</spage><epage>122</epage><pages>119-122</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-susceptibility contrast MR imaging the intensity-time curves of each tumor were analyzed, and we determined the relative regional cerebral blood volume ratios (rrCBV [tumor/contralateral white matter (WM)]) to find out whether these parameters could be used to separate PCNSL from GBM. The maximum rrCBV ratio in the PCNSL was significantly lower than that of the GBM (
P<0.0001). Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space. PCNSL tend to have low maximum CBV ratios and typical intensity-time curves. These two parameters may be useful in distinguishing PCNSL from GBM.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12566167</pmid><doi>10.1016/S0304-3940(02)01367-8</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Brain Neoplasms - blood supply Brain Neoplasms - diagnosis Brain Neoplasms - pathology Cerebral glioma Diagnosis, Differential Glioma - blood supply Glioma - diagnosis Glioma - pathology Humans Lymphoma Lymphoma - diagnosis Lymphoma - pathology Magnetic Resonance Imaging - methods Medical sciences Neurology Perfusion-weighted magnetic resonance imaging Severity of Illness Index Supratentorial Neoplasms - blood supply Supratentorial Neoplasms - diagnosis Supratentorial Neoplasms - pathology Tumors of the nervous system. Phacomatoses |
| title | Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging |
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