Study of the polyol pathway and cell permeability changes in human lens and retinal pigment epithelium in tissue culture

The polyol pathway was investigated in primary cultures of human retinal pigment epithelial (HRPE) cells and the results were compared with those in human lens epithelial (HLE) cells cultured under similar conditions. Significant levels of galactitol were formed in HRPE cells cultured for 72 hr in a...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1992-06, Vol.33 (7), p.2334-2339
Hauptverfasser:	Reddy, VN, Lin, LR, Giblin, FJ, Chakrapani, B, Yokoyama, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aldehyde Reductase - antagonists & inhibitors Biological and medical sciences Cell Membrane Permeability Cells, Cultured Chromatography, High Pressure Liquid Epithelium - metabolism Epithelium - ultrastructure Fundamental and applied biological sciences. Psychology Galactitol - antagonists & inhibitors Galactitol - metabolism Galactose - pharmacology Glutathione - metabolism Humans Inositol - metabolism Lens, Crystalline - metabolism Lens, Crystalline - ultrastructure Middle Aged Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Taurine - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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