A high-throughput nonisotopic protein truncation test

Nonsense or frameshift mutations, which result in a truncated gene product, are prevalent in a variety of disease-related genes 1 , including APC (implicated in colorectal cancer) 2 , 3 , 4 , 5 , 6 , BRCA1 and BRCA2 (breast and ovarian cancer) 7 , 8 , 9 , PKD1 (polycystic kidney disease) 10 , NF1 an...

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Veröffentlicht in:	Nature biotechnology 2003-02, Vol.21 (2), p.194-197
Hauptverfasser:	Gite, Sadanand, Lim, Mark, Carlson, Rick, Olejnik, Jerzy, Zehnbauer, Barbara, Rothschild, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli Protein - genetics Agriculture Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Breast cancer Chemiluminescence Codon, Nonsense - genetics Colorectal carcinoma Deoxyribonucleic acid DNA DNA Mutational Analysis - methods DNA, Neoplasm - genetics Dystrophy Feasibility Studies Frameshift Mutation - genetics Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Genes, APC Genetic technics applied to diagnosis Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Inspection Kidneys Life Sciences Mutation Ovarian cancer Polymerase Chain Reaction - methods Proteins - genetics RNA, Transfer Sequence Analysis, Protein - methods technical-report
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