Lower Blood Glucose, Hyperglucagonemia, and Pancreatic α Cell Hyperplasia in Glucagon Receptor Knockout Mice

Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in response to low blood glucose. To examine the role of glucagon in glucose homeostasis, mice were generated with a null mutation of the glucagon receptor (Gcgr-/-). These mice display lower blood glucose level...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-02, Vol.100 (3), p.1438-1443
Hauptverfasser:	Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., Johansen, P. B., Rossetti, L., Jelicks, L. A., Serup, P., Nishimura, E., Charron, M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Animals Biological Sciences Blood Glucose - metabolism Body Weight Calorimetry Cell Division Cellular biology Cyclic AMP - metabolism Epididymis - metabolism Epinephrine - pharmacology Fasting Glucagon - blood Glucose Glucose - metabolism Hormones Hormones - metabolism Hyperplasia Immunohistochemistry Insulin Insulin - metabolism Islets of Langerhans - pathology Lean body mass Liver Liver - metabolism Male Mice Mice, Inbred C57BL Microscopy, Fluorescence Pancreas Phenotype Receptors Receptors, Glucagon - genetics Receptors, Glucagon - physiology Rodents Time Factors
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