Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons
Among magnocellular neurosecretory neurons (MNCs), the frequency of dye coupling, and thus also of electrotonic coupling, is reduced in male rats following castration. Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal st...
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| Veröffentlicht in: | Brain research 1992-02, Vol.572 (1), p.291-295 |
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| creator | Hatton, G.I. Yang, Q.Z. Koran, L.E. |
| description | Among magnocellular neurosecretory neurons (MNCs), the frequency of dye coupling, and thus also of electrotonic coupling, is reduced in male rats following castration. Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal steroids in females influenced coupling incidence. Lucifer yellow CH injections were made in MNCs in slices taken from ovariectomized rats, either untreated or implanted with capsules containing estradiol-17β or estradiol-17α, or from sham operated rats. In groups without biologically active estradiol, incidence of dye coupling was increased by 138%–169% over those with normal plasma levels, as measured by radioimmunoassay. We conclude that estradiol and testosterone have opposite effects on coupling frequency among MNCs and that the facilitatory effects of testosterone in males are unlikely to be via its aromatization to estrogen. |
| doi_str_mv | 10.1016/0006-8993(92)90487-T |
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Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal steroids in females influenced coupling incidence. Lucifer yellow CH injections were made in MNCs in slices taken from ovariectomized rats, either untreated or implanted with capsules containing estradiol-17β or estradiol-17α, or from sham operated rats. In groups without biologically active estradiol, incidence of dye coupling was increased by 138%–169% over those with normal plasma levels, as measured by radioimmunoassay. We conclude that estradiol and testosterone have opposite effects on coupling frequency among MNCs and that the facilitatory effects of testosterone in males are unlikely to be via its aromatization to estrogen.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(92)90487-T</identifier><identifier>PMID: 1611526</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Estradiol - therapeutic use ; Estradiol-17α ; Estradiol-17β ; Estrogen Replacement Therapy ; Female ; Fluorescent Dyes - metabolism ; Fundamental and applied biological sciences. Psychology ; Gonadal steroid ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Intracellular recording ; Isoquinolines - metabolism ; Morphology. Functional localizations ; Neurons - drug effects ; Neurons - metabolism ; Ovariectomy ; Ovary - physiology ; Oxytocin ; Rats ; Rats, Inbred Strains ; Supraoptic nucleus ; Supraoptic Nucleus - cytology ; Supraoptic Nucleus - drug effects ; Supraoptic Nucleus - metabolism ; Vertebrates: endocrinology</subject><ispartof>Brain research, 1992-02, Vol.572 (1), p.291-295</ispartof><rights>1992 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-862853454615c2237cff9d4694956afec59ecbaac90f2a496e3153e429b015763</citedby><cites>FETCH-LOGICAL-c417t-862853454615c2237cff9d4694956afec59ecbaac90f2a496e3153e429b015763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(92)90487-T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5171883$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1611526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatton, G.I.</creatorcontrib><creatorcontrib>Yang, Q.Z.</creatorcontrib><creatorcontrib>Koran, L.E.</creatorcontrib><title>Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Among magnocellular neurosecretory neurons (MNCs), the frequency of dye coupling, and thus also of electrotonic coupling, is reduced in male rats following castration. Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal steroids in females influenced coupling incidence. Lucifer yellow CH injections were made in MNCs in slices taken from ovariectomized rats, either untreated or implanted with capsules containing estradiol-17β or estradiol-17α, or from sham operated rats. In groups without biologically active estradiol, incidence of dye coupling was increased by 138%–169% over those with normal plasma levels, as measured by radioimmunoassay. We conclude that estradiol and testosterone have opposite effects on coupling frequency among MNCs and that the facilitatory effects of testosterone in males are unlikely to be via its aromatization to estrogen.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Estradiol - therapeutic use</subject><subject>Estradiol-17α</subject><subject>Estradiol-17β</subject><subject>Estrogen Replacement Therapy</subject><subject>Female</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal steroid</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Intracellular recording</subject><subject>Isoquinolines - metabolism</subject><subject>Morphology. Functional localizations</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Ovariectomy</subject><subject>Ovary - physiology</subject><subject>Oxytocin</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Supraoptic nucleus</subject><subject>Supraoptic Nucleus - cytology</subject><subject>Supraoptic Nucleus - drug effects</subject><subject>Supraoptic Nucleus - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAUhUVpSSZp_0ECWpSQLJzqbWtTKCGPQqCbyVpo5KugYEuuZAfm31eTGdJdu5G43O8eDucgdEbJNSVUfSOEqKbTml9qdqWJ6Npm_QGtaNeyRjFBPqLVO3KMTkp5qSPnmhyhI6oolUytUH_rPbi54ORxerU51CGNW2xjj6HMOT1DxBmmwToYIc44RdxvAbu0TEOIz9iOqb7ZzrgsU7ZpmoPDcXEDLAVHWHKK5TP65O1Q4MvhP0VPd7frm4fm8df9z5sfj40TtJ2bTrFOciGFotIxxlvnve6F0kJLZatNqcFtrHWaeGaFVsCp5CCY3hAqW8VP0cVed8rp91LtmzEUB8NgI6SlmJZp3XIl_wvWeDqqxE5R7EGXUykZvJlyGG3eGkrMrgWzi9jsIjaambcWzLqenR_0l80I_d-jfex1__Wwt8XZwWcbXSjvmKQt7Tpese97DGporwGyKS5AdNCHXHsyfQr_9vEHbbOkFw</recordid><startdate>19920214</startdate><enddate>19920214</enddate><creator>Hatton, G.I.</creator><creator>Yang, Q.Z.</creator><creator>Koran, L.E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920214</creationdate><title>Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons</title><author>Hatton, G.I. ; Yang, Q.Z. ; Koran, L.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-862853454615c2237cff9d4694956afec59ecbaac90f2a496e3153e429b015763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Estradiol - therapeutic use</topic><topic>Estradiol-17α</topic><topic>Estradiol-17β</topic><topic>Estrogen Replacement Therapy</topic><topic>Female</topic><topic>Fluorescent Dyes - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal steroid</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Intracellular recording</topic><topic>Isoquinolines - metabolism</topic><topic>Morphology. Functional localizations</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Ovariectomy</topic><topic>Ovary - physiology</topic><topic>Oxytocin</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Supraoptic nucleus</topic><topic>Supraoptic Nucleus - cytology</topic><topic>Supraoptic Nucleus - drug effects</topic><topic>Supraoptic Nucleus - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatton, G.I.</creatorcontrib><creatorcontrib>Yang, Q.Z.</creatorcontrib><creatorcontrib>Koran, L.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatton, G.I.</au><au>Yang, Q.Z.</au><au>Koran, L.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1992-02-14</date><risdate>1992</risdate><volume>572</volume><issue>1</issue><spage>291</spage><epage>295</epage><pages>291-295</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Among magnocellular neurosecretory neurons (MNCs), the frequency of dye coupling, and thus also of electrotonic coupling, is reduced in male rats following castration. Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal steroids in females influenced coupling incidence. Lucifer yellow CH injections were made in MNCs in slices taken from ovariectomized rats, either untreated or implanted with capsules containing estradiol-17β or estradiol-17α, or from sham operated rats. In groups without biologically active estradiol, incidence of dye coupling was increased by 138%–169% over those with normal plasma levels, as measured by radioimmunoassay. We conclude that estradiol and testosterone have opposite effects on coupling frequency among MNCs and that the facilitatory effects of testosterone in males are unlikely to be via its aromatization to estrogen.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1611526</pmid><doi>10.1016/0006-8993(92)90487-T</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Estradiol - therapeutic use Estradiol-17α Estradiol-17β Estrogen Replacement Therapy Female Fluorescent Dyes - metabolism Fundamental and applied biological sciences. Psychology Gonadal steroid Hypothalamus. Hypophysis. Epiphysis. Urophysis Intracellular recording Isoquinolines - metabolism Morphology. Functional localizations Neurons - drug effects Neurons - metabolism Ovariectomy Ovary - physiology Oxytocin Rats Rats, Inbred Strains Supraoptic nucleus Supraoptic Nucleus - cytology Supraoptic Nucleus - drug effects Supraoptic Nucleus - metabolism Vertebrates: endocrinology |
| title | Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons |
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