Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creat...
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| Veröffentlicht in: | Annals of neurology 2003-02, Vol.53 (2), p.267-270 |
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| container_title | Annals of neurology |
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| creator | Zhang, Wenhua Narayanan, Malini Friedlander, Robert M. |
| description | The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that combination of minocycline and creatine resulted in additive neuroprotection, suggesting this to be a novel potential strategy for the treatment of ALS. To our knowledge, this is the first report demonstrating additive neuroprotection of a combinatorial approach in a mouse model of ALS. Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood–brain barrier, and are currently available for human evaluation. |
| doi_str_mv | 10.1002/ana.10476 |
| format | Article |
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As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that combination of minocycline and creatine resulted in additive neuroprotection, suggesting this to be a novel potential strategy for the treatment of ALS. To our knowledge, this is the first report demonstrating additive neuroprotection of a combinatorial approach in a mouse model of ALS. Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood–brain barrier, and are currently available for human evaluation.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.10476</identifier><identifier>PMID: 12557297</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Amyotrophic Lateral Sclerosis - drug therapy ; Amyotrophic Lateral Sclerosis - genetics ; Amyotrophic Lateral Sclerosis - mortality ; Animals ; Anti-Bacterial Agents - pharmacology ; Biological and medical sciences ; Creatine - pharmacology ; Disease Models, Animal ; Drug Therapy, Combination ; Medical sciences ; Mice ; Mice, Mutant Strains ; Minocycline - pharmacology ; Neuropharmacology ; Neuroprotective agent ; Neuroprotective Agents - pharmacology ; Pharmacology. Drug treatments ; Superoxide Dismutase - genetics ; Superoxide Dismutase-1 ; Survival Analysis</subject><ispartof>Annals of neurology, 2003-02, Vol.53 (2), p.267-270</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3896-5a5a5665bcbbc17b7522a2dcf64adac16a312b2ff83d0d6fff8f81f4ae0b48993</citedby><cites>FETCH-LOGICAL-c3896-5a5a5665bcbbc17b7522a2dcf64adac16a312b2ff83d0d6fff8f81f4ae0b48993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.10476$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.10476$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14526941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12557297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Wenhua</creatorcontrib><creatorcontrib>Narayanan, Malini</creatorcontrib><creatorcontrib>Friedlander, Robert M.</creatorcontrib><title>Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that combination of minocycline and creatine resulted in additive neuroprotection, suggesting this to be a novel potential strategy for the treatment of ALS. To our knowledge, this is the first report demonstrating additive neuroprotection of a combinatorial approach in a mouse model of ALS. Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood–brain barrier, and are currently available for human evaluation.</description><subject>Amyotrophic Lateral Sclerosis - drug therapy</subject><subject>Amyotrophic Lateral Sclerosis - genetics</subject><subject>Amyotrophic Lateral Sclerosis - mortality</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Creatine - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Drug Therapy, Combination</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Minocycline - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase-1</subject><subject>Survival Analysis</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtO3DAUhi1EBcNlwQugbKjEIsX3JMsIwQAa0QVFLK0T51g1zYXaGei8PR5mWlaVpeP_SN-5_YScMPqNUcovYIAkZKF3yIwpwfKSy2qXzKjQMldMyH1yEOMzpbTSjO6RfcaVKnhVzMhj3bZ-8q-YDbgM40sYJ7QfOTqXVMxGl_V-GO3Kdn7A7M1PPzMbEKZ15ocMsn5cRkyxxW5N14uHI_LFQRfxePsfksfrqx-XN_ni-_z2sl7kVpSVzhWkp7VqbNNYVjSF4hx4a52W0IJlGgTjDXeuFC1ttUvClcxJQNrIsqrEIfm66Zv2_r3EOJneR4tdBwOmpUy6MV3MdALPN6ANY4wBnXkJvoewMoyatYcmeWg-PEzs6bbpsumx_SS3piXgbAtAtNC5AIP18ZOTiutKssRdbLg33-Hq_xNNfV__HZ1vKnyc8M-_Cgi_jC5EoczT_dxQUdzNywdprsU7oyKXgg</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Zhang, Wenhua</creator><creator>Narayanan, Malini</creator><creator>Friedlander, Robert M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS</title><author>Zhang, Wenhua ; Narayanan, Malini ; Friedlander, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3896-5a5a5665bcbbc17b7522a2dcf64adac16a312b2ff83d0d6fff8f81f4ae0b48993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amyotrophic Lateral Sclerosis - drug therapy</topic><topic>Amyotrophic Lateral Sclerosis - genetics</topic><topic>Amyotrophic Lateral Sclerosis - mortality</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Creatine - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Drug Therapy, Combination</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Minocycline - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase-1</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Wenhua</creatorcontrib><creatorcontrib>Narayanan, Malini</creatorcontrib><creatorcontrib>Friedlander, Robert M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Wenhua</au><au>Narayanan, Malini</au><au>Friedlander, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>53</volume><issue>2</issue><spage>267</spage><epage>270</epage><pages>267-270</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that combination of minocycline and creatine resulted in additive neuroprotection, suggesting this to be a novel potential strategy for the treatment of ALS. To our knowledge, this is the first report demonstrating additive neuroprotection of a combinatorial approach in a mouse model of ALS. Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood–brain barrier, and are currently available for human evaluation.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12557297</pmid><doi>10.1002/ana.10476</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of neurology, 2003-02, Vol.53 (2), p.267-270 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - mortality Animals Anti-Bacterial Agents - pharmacology Biological and medical sciences Creatine - pharmacology Disease Models, Animal Drug Therapy, Combination Medical sciences Mice Mice, Mutant Strains Minocycline - pharmacology Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Pharmacology. Drug treatments Superoxide Dismutase - genetics Superoxide Dismutase-1 Survival Analysis |
| title | Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS |
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