Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial
In the first field trial with synthetic malaria vaccine SPf66 in a large population naturally exposed to malaria, 9957 persons > 1 year old and residing on the Colombian Pacific coast received three doses of the vaccine. To evaluate vaccine safety, clinical observations were made 30 min and 48 h...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 1992-07, Vol.166 (1), p.139-144 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 144 |
|---|---|
| container_issue | 1 |
| container_start_page | 139 |
| container_title | The Journal of infectious diseases |
| container_volume | 166 |
| creator | Amador, Roberto Moreno, Alberto Murillo, Luis Angel Sierra, Oscar Saavedra, David Rojas, Mauricio Mora, Ana Lucia Rocha, Claudia Lucia Alvarado, Fernando Falla, Juan Carlos Orozco, Mauricio Coronell, Carlos Ortega, Norella Molano, Alberto Velásquez, José Fernando Valero, María Victoria Franco, Lina Guzmán, Fanny Salazar, Luz Mary Espejo, Fabiola Mora, Elsa Farfán, Rocío Zapata, Nohora Rosas, Jaiver Calvo, Julio Cesar Castro, Jaime Quiñones, Teódulo Nuñez, Francisco Patarroyo, Manuel Elkin |
| description | In the first field trial with synthetic malaria vaccine SPf66 in a large population naturally exposed to malaria, 9957 persons > 1 year old and residing on the Colombian Pacific coast received three doses of the vaccine. To evaluate vaccine safety, clinical observations were made 30 min and 48 h after each immunization. There were no adverse reactions in 95.7% of cases. In the 4.3% of cases with adverse reactions, local induration and erythema were the most frequent. In a randomly selected group of vaccinees, anti-SPf66 antibody titers were measured after the third dose: 93% of the vaccinees raised antibodies to SPf66. Among these, 55% had titers > 1:1600. These results demonstrate the safety and immunogenicity of the SPf66 vaccine in a large field trial. |
| doi_str_mv | 10.1093/infdis/166.1.139 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72994703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30112243</jstor_id><sourcerecordid>30112243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-61d5c1dbd4b549aa0df87e8454ab76ef4c2a53cedbe3fc6d8e391f62c923bebd3</originalsourceid><addsrcrecordid>eNqFkM1rFTEUxYNY6rN270bIyt285iaZZLKUYm3hiQ_6Jd2ETHJTU-ejJvPA9987ZUq7dHXg_s45XA4hH4GtgRlxkoYYUjkBpdawBmHekBXUQldKgXhLVoxxXkFjzDvyvpQHxpgUSh-SQ1BMq6ZekdtLF3HaUzcEetH3u2G8xyH5NJ_GSKdfSC_3wyxT8vS761xOjt4479Mwk21UiqaBOrpx-R7pWcIu0KvZ030gB9F1BY-f9Yhcn329Oj2vNj--XZx-2VRecj1VCkLtIbRBtrU0zrEQG42NrKVrtcIoPXe18BhaFNGr0KAwEBX3hosW2yCOyOel9zGPf3ZYJtun4rHr3IDjrljNjZGaif8aQQmQgjezkS1Gn8dSMkb7mFPv8t4Cs0-j22X0OaEs2Hn0OfLpuXvX9hheA8vKr_yhTGN-wYIBcC6ffqsWnsqEf1-4y7-t0kLX9vznnb3Z3jY16K3V4h9mAZdP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16314328</pqid></control><display><type>article</type><title>Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Amador, Roberto ; Moreno, Alberto ; Murillo, Luis Angel ; Sierra, Oscar ; Saavedra, David ; Rojas, Mauricio ; Mora, Ana Lucia ; Rocha, Claudia Lucia ; Alvarado, Fernando ; Falla, Juan Carlos ; Orozco, Mauricio ; Coronell, Carlos ; Ortega, Norella ; Molano, Alberto ; Velásquez, José Fernando ; Valero, María Victoria ; Franco, Lina ; Guzmán, Fanny ; Salazar, Luz Mary ; Espejo, Fabiola ; Mora, Elsa ; Farfán, Rocío ; Zapata, Nohora ; Rosas, Jaiver ; Calvo, Julio Cesar ; Castro, Jaime ; Quiñones, Teódulo ; Nuñez, Francisco ; Patarroyo, Manuel Elkin</creator><creatorcontrib>Amador, Roberto ; Moreno, Alberto ; Murillo, Luis Angel ; Sierra, Oscar ; Saavedra, David ; Rojas, Mauricio ; Mora, Ana Lucia ; Rocha, Claudia Lucia ; Alvarado, Fernando ; Falla, Juan Carlos ; Orozco, Mauricio ; Coronell, Carlos ; Ortega, Norella ; Molano, Alberto ; Velásquez, José Fernando ; Valero, María Victoria ; Franco, Lina ; Guzmán, Fanny ; Salazar, Luz Mary ; Espejo, Fabiola ; Mora, Elsa ; Farfán, Rocío ; Zapata, Nohora ; Rosas, Jaiver ; Calvo, Julio Cesar ; Castro, Jaime ; Quiñones, Teódulo ; Nuñez, Francisco ; Patarroyo, Manuel Elkin</creatorcontrib><description>In the first field trial with synthetic malaria vaccine SPf66 in a large population naturally exposed to malaria, 9957 persons > 1 year old and residing on the Colombian Pacific coast received three doses of the vaccine. To evaluate vaccine safety, clinical observations were made 30 min and 48 h after each immunization. There were no adverse reactions in 95.7% of cases. In the 4.3% of cases with adverse reactions, local induration and erythema were the most frequent. In a randomly selected group of vaccinees, anti-SPf66 antibody titers were measured after the third dose: 93% of the vaccinees raised antibodies to SPf66. Among these, 55% had titers > 1:1600. These results demonstrate the safety and immunogenicity of the SPf66 vaccine in a large field trial.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/166.1.139</identifier><identifier>PMID: 1607685</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Amino Acid Sequence ; Animals ; Antibodies ; Antibodies, Protozoan - biosynthesis ; Blood Pressure ; Blotting, Western ; Child ; Child, Preschool ; Dosage ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immune response ; Immunization ; Immunoglobulin G - biosynthesis ; Infant ; Major Articles ; Malaria ; Malaria vaccine ; Malaria, Falciparum - prevention & control ; Male ; Molecular Sequence Data ; Parasites ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Polymers ; Protozoan Proteins - adverse effects ; Protozoan Proteins - chemistry ; Protozoan Proteins - immunology ; Protozoan Vaccines - adverse effects ; Protozoan Vaccines - chemistry ; Protozoan Vaccines - immunology ; Pruritus ; Recombinant Proteins ; Vaccination ; Vaccination - adverse effects</subject><ispartof>The Journal of infectious diseases, 1992-07, Vol.166 (1), p.139-144</ispartof><rights>Copyright 1992 The University of Chicago</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-61d5c1dbd4b549aa0df87e8454ab76ef4c2a53cedbe3fc6d8e391f62c923bebd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112243$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112243$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1607685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amador, Roberto</creatorcontrib><creatorcontrib>Moreno, Alberto</creatorcontrib><creatorcontrib>Murillo, Luis Angel</creatorcontrib><creatorcontrib>Sierra, Oscar</creatorcontrib><creatorcontrib>Saavedra, David</creatorcontrib><creatorcontrib>Rojas, Mauricio</creatorcontrib><creatorcontrib>Mora, Ana Lucia</creatorcontrib><creatorcontrib>Rocha, Claudia Lucia</creatorcontrib><creatorcontrib>Alvarado, Fernando</creatorcontrib><creatorcontrib>Falla, Juan Carlos</creatorcontrib><creatorcontrib>Orozco, Mauricio</creatorcontrib><creatorcontrib>Coronell, Carlos</creatorcontrib><creatorcontrib>Ortega, Norella</creatorcontrib><creatorcontrib>Molano, Alberto</creatorcontrib><creatorcontrib>Velásquez, José Fernando</creatorcontrib><creatorcontrib>Valero, María Victoria</creatorcontrib><creatorcontrib>Franco, Lina</creatorcontrib><creatorcontrib>Guzmán, Fanny</creatorcontrib><creatorcontrib>Salazar, Luz Mary</creatorcontrib><creatorcontrib>Espejo, Fabiola</creatorcontrib><creatorcontrib>Mora, Elsa</creatorcontrib><creatorcontrib>Farfán, Rocío</creatorcontrib><creatorcontrib>Zapata, Nohora</creatorcontrib><creatorcontrib>Rosas, Jaiver</creatorcontrib><creatorcontrib>Calvo, Julio Cesar</creatorcontrib><creatorcontrib>Castro, Jaime</creatorcontrib><creatorcontrib>Quiñones, Teódulo</creatorcontrib><creatorcontrib>Nuñez, Francisco</creatorcontrib><creatorcontrib>Patarroyo, Manuel Elkin</creatorcontrib><title>Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>In the first field trial with synthetic malaria vaccine SPf66 in a large population naturally exposed to malaria, 9957 persons > 1 year old and residing on the Colombian Pacific coast received three doses of the vaccine. To evaluate vaccine safety, clinical observations were made 30 min and 48 h after each immunization. There were no adverse reactions in 95.7% of cases. In the 4.3% of cases with adverse reactions, local induration and erythema were the most frequent. In a randomly selected group of vaccinees, anti-SPf66 antibody titers were measured after the third dose: 93% of the vaccinees raised antibodies to SPf66. Among these, 55% had titers > 1:1600. These results demonstrate the safety and immunogenicity of the SPf66 vaccine in a large field trial.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>Blood Pressure</subject><subject>Blotting, Western</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dosage</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Infant</subject><subject>Major Articles</subject><subject>Malaria</subject><subject>Malaria vaccine</subject><subject>Malaria, Falciparum - prevention & control</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Parasites</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Polymers</subject><subject>Protozoan Proteins - adverse effects</subject><subject>Protozoan Proteins - chemistry</subject><subject>Protozoan Proteins - immunology</subject><subject>Protozoan Vaccines - adverse effects</subject><subject>Protozoan Vaccines - chemistry</subject><subject>Protozoan Vaccines - immunology</subject><subject>Pruritus</subject><subject>Recombinant Proteins</subject><subject>Vaccination</subject><subject>Vaccination - adverse effects</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1rFTEUxYNY6rN270bIyt285iaZZLKUYm3hiQ_6Jd2ETHJTU-ejJvPA9987ZUq7dHXg_s45XA4hH4GtgRlxkoYYUjkBpdawBmHekBXUQldKgXhLVoxxXkFjzDvyvpQHxpgUSh-SQ1BMq6ZekdtLF3HaUzcEetH3u2G8xyH5NJ_GSKdfSC_3wyxT8vS761xOjt4479Mwk21UiqaBOrpx-R7pWcIu0KvZ030gB9F1BY-f9Yhcn329Oj2vNj--XZx-2VRecj1VCkLtIbRBtrU0zrEQG42NrKVrtcIoPXe18BhaFNGr0KAwEBX3hosW2yCOyOel9zGPf3ZYJtun4rHr3IDjrljNjZGaif8aQQmQgjezkS1Gn8dSMkb7mFPv8t4Cs0-j22X0OaEs2Hn0OfLpuXvX9hheA8vKr_yhTGN-wYIBcC6ffqsWnsqEf1-4y7-t0kLX9vznnb3Z3jY16K3V4h9mAZdP</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Amador, Roberto</creator><creator>Moreno, Alberto</creator><creator>Murillo, Luis Angel</creator><creator>Sierra, Oscar</creator><creator>Saavedra, David</creator><creator>Rojas, Mauricio</creator><creator>Mora, Ana Lucia</creator><creator>Rocha, Claudia Lucia</creator><creator>Alvarado, Fernando</creator><creator>Falla, Juan Carlos</creator><creator>Orozco, Mauricio</creator><creator>Coronell, Carlos</creator><creator>Ortega, Norella</creator><creator>Molano, Alberto</creator><creator>Velásquez, José Fernando</creator><creator>Valero, María Victoria</creator><creator>Franco, Lina</creator><creator>Guzmán, Fanny</creator><creator>Salazar, Luz Mary</creator><creator>Espejo, Fabiola</creator><creator>Mora, Elsa</creator><creator>Farfán, Rocío</creator><creator>Zapata, Nohora</creator><creator>Rosas, Jaiver</creator><creator>Calvo, Julio Cesar</creator><creator>Castro, Jaime</creator><creator>Quiñones, Teódulo</creator><creator>Nuñez, Francisco</creator><creator>Patarroyo, Manuel Elkin</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial</title><author>Amador, Roberto ; Moreno, Alberto ; Murillo, Luis Angel ; Sierra, Oscar ; Saavedra, David ; Rojas, Mauricio ; Mora, Ana Lucia ; Rocha, Claudia Lucia ; Alvarado, Fernando ; Falla, Juan Carlos ; Orozco, Mauricio ; Coronell, Carlos ; Ortega, Norella ; Molano, Alberto ; Velásquez, José Fernando ; Valero, María Victoria ; Franco, Lina ; Guzmán, Fanny ; Salazar, Luz Mary ; Espejo, Fabiola ; Mora, Elsa ; Farfán, Rocío ; Zapata, Nohora ; Rosas, Jaiver ; Calvo, Julio Cesar ; Castro, Jaime ; Quiñones, Teódulo ; Nuñez, Francisco ; Patarroyo, Manuel Elkin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-61d5c1dbd4b549aa0df87e8454ab76ef4c2a53cedbe3fc6d8e391f62c923bebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>Blood Pressure</topic><topic>Blotting, Western</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dosage</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunization</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Infant</topic><topic>Major Articles</topic><topic>Malaria</topic><topic>Malaria vaccine</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Parasites</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>Polymers</topic><topic>Protozoan Proteins - adverse effects</topic><topic>Protozoan Proteins - chemistry</topic><topic>Protozoan Proteins - immunology</topic><topic>Protozoan Vaccines - adverse effects</topic><topic>Protozoan Vaccines - chemistry</topic><topic>Protozoan Vaccines - immunology</topic><topic>Pruritus</topic><topic>Recombinant Proteins</topic><topic>Vaccination</topic><topic>Vaccination - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amador, Roberto</creatorcontrib><creatorcontrib>Moreno, Alberto</creatorcontrib><creatorcontrib>Murillo, Luis Angel</creatorcontrib><creatorcontrib>Sierra, Oscar</creatorcontrib><creatorcontrib>Saavedra, David</creatorcontrib><creatorcontrib>Rojas, Mauricio</creatorcontrib><creatorcontrib>Mora, Ana Lucia</creatorcontrib><creatorcontrib>Rocha, Claudia Lucia</creatorcontrib><creatorcontrib>Alvarado, Fernando</creatorcontrib><creatorcontrib>Falla, Juan Carlos</creatorcontrib><creatorcontrib>Orozco, Mauricio</creatorcontrib><creatorcontrib>Coronell, Carlos</creatorcontrib><creatorcontrib>Ortega, Norella</creatorcontrib><creatorcontrib>Molano, Alberto</creatorcontrib><creatorcontrib>Velásquez, José Fernando</creatorcontrib><creatorcontrib>Valero, María Victoria</creatorcontrib><creatorcontrib>Franco, Lina</creatorcontrib><creatorcontrib>Guzmán, Fanny</creatorcontrib><creatorcontrib>Salazar, Luz Mary</creatorcontrib><creatorcontrib>Espejo, Fabiola</creatorcontrib><creatorcontrib>Mora, Elsa</creatorcontrib><creatorcontrib>Farfán, Rocío</creatorcontrib><creatorcontrib>Zapata, Nohora</creatorcontrib><creatorcontrib>Rosas, Jaiver</creatorcontrib><creatorcontrib>Calvo, Julio Cesar</creatorcontrib><creatorcontrib>Castro, Jaime</creatorcontrib><creatorcontrib>Quiñones, Teódulo</creatorcontrib><creatorcontrib>Nuñez, Francisco</creatorcontrib><creatorcontrib>Patarroyo, Manuel Elkin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amador, Roberto</au><au>Moreno, Alberto</au><au>Murillo, Luis Angel</au><au>Sierra, Oscar</au><au>Saavedra, David</au><au>Rojas, Mauricio</au><au>Mora, Ana Lucia</au><au>Rocha, Claudia Lucia</au><au>Alvarado, Fernando</au><au>Falla, Juan Carlos</au><au>Orozco, Mauricio</au><au>Coronell, Carlos</au><au>Ortega, Norella</au><au>Molano, Alberto</au><au>Velásquez, José Fernando</au><au>Valero, María Victoria</au><au>Franco, Lina</au><au>Guzmán, Fanny</au><au>Salazar, Luz Mary</au><au>Espejo, Fabiola</au><au>Mora, Elsa</au><au>Farfán, Rocío</au><au>Zapata, Nohora</au><au>Rosas, Jaiver</au><au>Calvo, Julio Cesar</au><au>Castro, Jaime</au><au>Quiñones, Teódulo</au><au>Nuñez, Francisco</au><au>Patarroyo, Manuel Elkin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>166</volume><issue>1</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>In the first field trial with synthetic malaria vaccine SPf66 in a large population naturally exposed to malaria, 9957 persons > 1 year old and residing on the Colombian Pacific coast received three doses of the vaccine. To evaluate vaccine safety, clinical observations were made 30 min and 48 h after each immunization. There were no adverse reactions in 95.7% of cases. In the 4.3% of cases with adverse reactions, local induration and erythema were the most frequent. In a randomly selected group of vaccinees, anti-SPf66 antibody titers were measured after the third dose: 93% of the vaccinees raised antibodies to SPf66. Among these, 55% had titers > 1:1600. These results demonstrate the safety and immunogenicity of the SPf66 vaccine in a large field trial.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>1607685</pmid><doi>10.1093/infdis/166.1.139</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1992-07, Vol.166 (1), p.139-144 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72994703 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adolescent Adult Amino Acid Sequence Animals Antibodies Antibodies, Protozoan - biosynthesis Blood Pressure Blotting, Western Child Child, Preschool Dosage Enzyme-Linked Immunosorbent Assay Female Humans Immune response Immunization Immunoglobulin G - biosynthesis Infant Major Articles Malaria Malaria vaccine Malaria, Falciparum - prevention & control Male Molecular Sequence Data Parasites Plasmodium falciparum Plasmodium falciparum - immunology Polymers Protozoan Proteins - adverse effects Protozoan Proteins - chemistry Protozoan Proteins - immunology Protozoan Vaccines - adverse effects Protozoan Vaccines - chemistry Protozoan Vaccines - immunology Pruritus Recombinant Proteins Vaccination Vaccination - adverse effects |
| title | Safety and Immunogenicity of the Synthetic Malaria Vaccine SPf66 in a Large Field Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A13%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety%20and%20Immunogenicity%20of%20the%20Synthetic%20Malaria%20Vaccine%20SPf66%20in%20a%20Large%20Field%20Trial&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Amador,%20Roberto&rft.date=1992-07-01&rft.volume=166&rft.issue=1&rft.spage=139&rft.epage=144&rft.pages=139-144&rft.issn=0022-1899&rft.eissn=1537-6613&rft_id=info:doi/10.1093/infdis/166.1.139&rft_dat=%3Cjstor_proqu%3E30112243%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16314328&rft_id=info:pmid/1607685&rft_jstor_id=30112243&rfr_iscdi=true |