Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia
Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1–3, were distinct from Ha...
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| Veröffentlicht in: | The Journal of infectious diseases 1992-07, Vol.166 (1), p.113-120 |
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| creator | Gligic, Ana Dimkovic, Nada Xiao, Shu-Yuan Buckle, Guy J. Jovanovic, Dragan Velimirovic, Dragisa Stojanovic, Radivoj Obradovic, Mirceta Diglisic, Gordana Micic, Jasmina Asher, David M. LeDuc, James W. Yanagihara, Richard Carleton Gajdusek, D. |
| description | Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1–3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia. |
| doi_str_mv | 10.1093/infdis/166.1.113 |
| format | Article |
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Viral isolates from three patients, designated strains Belgrade 1–3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/166.1.113</identifier><identifier>PMID: 1351508</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Animals ; Antibodies ; Antibodies, Viral - blood ; Antigens, Viral - blood ; Antigens, Viral - urine ; Biological and medical sciences ; Blood ; Cross Reactions ; Epidemiology ; Fever ; Fluorescent Antibody Technique ; Gene Amplification ; Hantaan virus ; Hantavirus ; Hantavirus - genetics ; Hantavirus - immunology ; Hantavirus - isolation & purification ; Hantavirus - ultrastructure ; Hemorrhagic fever with renal syndrome ; Hemorrhagic Fever with Renal Syndrome - microbiology ; Humans ; Infectious diseases ; Major Articles ; Male ; Medical sciences ; Mice ; Microscopy, Electron ; Microscopy, Immunoelectron ; Middle Aged ; Neutralization Tests ; Puumala virus ; RNA, Viral - analysis ; Urine ; Viruses ; Yugoslavia</subject><ispartof>The Journal of infectious diseases, 1992-07, Vol.166 (1), p.113-120</ispartof><rights>Copyright 1992 The University of Chicago</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-8faea759c93cf9d2162a198724e3df17fb7b6ba7d951d07cccad87cc01cc2cfa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112240$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112240$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4420570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1351508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gligic, Ana</creatorcontrib><creatorcontrib>Dimkovic, Nada</creatorcontrib><creatorcontrib>Xiao, Shu-Yuan</creatorcontrib><creatorcontrib>Buckle, Guy J.</creatorcontrib><creatorcontrib>Jovanovic, Dragan</creatorcontrib><creatorcontrib>Velimirovic, Dragisa</creatorcontrib><creatorcontrib>Stojanovic, Radivoj</creatorcontrib><creatorcontrib>Obradovic, Mirceta</creatorcontrib><creatorcontrib>Diglisic, Gordana</creatorcontrib><creatorcontrib>Micic, Jasmina</creatorcontrib><creatorcontrib>Asher, David M.</creatorcontrib><creatorcontrib>LeDuc, James W.</creatorcontrib><creatorcontrib>Yanagihara, Richard</creatorcontrib><creatorcontrib>Carleton Gajdusek, D.</creatorcontrib><title>Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1–3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.</description><subject>Adult</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens, Viral - blood</subject><subject>Antigens, Viral - urine</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cross Reactions</subject><subject>Epidemiology</subject><subject>Fever</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Amplification</subject><subject>Hantaan virus</subject><subject>Hantavirus</subject><subject>Hantavirus - genetics</subject><subject>Hantavirus - immunology</subject><subject>Hantavirus - isolation & purification</subject><subject>Hantavirus - ultrastructure</subject><subject>Hemorrhagic fever with renal syndrome</subject><subject>Hemorrhagic Fever with Renal Syndrome - microbiology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Immunoelectron</subject><subject>Middle Aged</subject><subject>Neutralization Tests</subject><subject>Puumala virus</subject><subject>RNA, Viral - analysis</subject><subject>Urine</subject><subject>Viruses</subject><subject>Yugoslavia</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS1EVZaWOxckHxC3bD12Ysfc2hXdRapA0AKFizVrO1uXfBQ7ael_36yytEdOI83vvTfSPEJeA5sD0-IotJUL6QiknMMcQDwjMyiEyqQE8ZzMGOM8g1LrF-RlSteMsVxItU_2QRRQsHJG7ImvNxGdp99DHNJ7ekw_-Tu6wrbH2-2GLnBIod3Qc3_ro6cr33QxXuEmWHq6XdG70F_Rr77Fmp7fty52jaehpT-HTZfqMQQPyV6FdfKvdvOAfDv9cLFYZWeflx8Xx2eZzSHvs7JCj6rQVgtbacdBcgRdKp574SpQ1Vqt5RqV0wU4pqy16MpxMLCW2wrFAXk35d7E7s_gU2-akKyva2x9NySjuNZ5UYr_CsfLCriGUcgmoY1dStFX5iaGBuO9AWa2BZipgNEhDZixgNHyZpc9rBvvngzTx0f-dscxWayriK0dA_7J8pyzQrGnmOvUd_ERCwbAeb7l2cRD6v3fR47xt5FKqMKsLn8ZrX5cLtXyi5HiAZEPqPU</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Gligic, Ana</creator><creator>Dimkovic, Nada</creator><creator>Xiao, Shu-Yuan</creator><creator>Buckle, Guy J.</creator><creator>Jovanovic, Dragan</creator><creator>Velimirovic, Dragisa</creator><creator>Stojanovic, Radivoj</creator><creator>Obradovic, Mirceta</creator><creator>Diglisic, Gordana</creator><creator>Micic, Jasmina</creator><creator>Asher, David M.</creator><creator>LeDuc, James W.</creator><creator>Yanagihara, Richard</creator><creator>Carleton Gajdusek, D.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia</title><author>Gligic, Ana ; Dimkovic, Nada ; Xiao, Shu-Yuan ; Buckle, Guy J. ; Jovanovic, Dragan ; Velimirovic, Dragisa ; Stojanovic, Radivoj ; Obradovic, Mirceta ; Diglisic, Gordana ; Micic, Jasmina ; Asher, David M. ; LeDuc, James W. ; Yanagihara, Richard ; Carleton Gajdusek, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-8faea759c93cf9d2162a198724e3df17fb7b6ba7d951d07cccad87cc01cc2cfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens, Viral - blood</topic><topic>Antigens, Viral - urine</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cross Reactions</topic><topic>Epidemiology</topic><topic>Fever</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Amplification</topic><topic>Hantaan virus</topic><topic>Hantavirus</topic><topic>Hantavirus - genetics</topic><topic>Hantavirus - immunology</topic><topic>Hantavirus - isolation & purification</topic><topic>Hantavirus - ultrastructure</topic><topic>Hemorrhagic fever with renal syndrome</topic><topic>Hemorrhagic Fever with Renal Syndrome - microbiology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Immunoelectron</topic><topic>Middle Aged</topic><topic>Neutralization Tests</topic><topic>Puumala virus</topic><topic>RNA, Viral - analysis</topic><topic>Urine</topic><topic>Viruses</topic><topic>Yugoslavia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gligic, Ana</creatorcontrib><creatorcontrib>Dimkovic, Nada</creatorcontrib><creatorcontrib>Xiao, Shu-Yuan</creatorcontrib><creatorcontrib>Buckle, Guy J.</creatorcontrib><creatorcontrib>Jovanovic, Dragan</creatorcontrib><creatorcontrib>Velimirovic, Dragisa</creatorcontrib><creatorcontrib>Stojanovic, Radivoj</creatorcontrib><creatorcontrib>Obradovic, Mirceta</creatorcontrib><creatorcontrib>Diglisic, Gordana</creatorcontrib><creatorcontrib>Micic, Jasmina</creatorcontrib><creatorcontrib>Asher, David M.</creatorcontrib><creatorcontrib>LeDuc, James W.</creatorcontrib><creatorcontrib>Yanagihara, Richard</creatorcontrib><creatorcontrib>Carleton Gajdusek, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gligic, Ana</au><au>Dimkovic, Nada</au><au>Xiao, Shu-Yuan</au><au>Buckle, Guy J.</au><au>Jovanovic, Dragan</au><au>Velimirovic, Dragisa</au><au>Stojanovic, Radivoj</au><au>Obradovic, Mirceta</au><au>Diglisic, Gordana</au><au>Micic, Jasmina</au><au>Asher, David M.</au><au>LeDuc, James W.</au><au>Yanagihara, Richard</au><au>Carleton Gajdusek, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>166</volume><issue>1</issue><spage>113</spage><epage>120</epage><pages>113-120</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1–3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>1351508</pmid><doi>10.1093/infdis/166.1.113</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1992-07, Vol.166 (1), p.113-120 |
| issn | 0022-1899 1537-6613 |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adult Animals Antibodies Antibodies, Viral - blood Antigens, Viral - blood Antigens, Viral - urine Biological and medical sciences Blood Cross Reactions Epidemiology Fever Fluorescent Antibody Technique Gene Amplification Hantaan virus Hantavirus Hantavirus - genetics Hantavirus - immunology Hantavirus - isolation & purification Hantavirus - ultrastructure Hemorrhagic fever with renal syndrome Hemorrhagic Fever with Renal Syndrome - microbiology Humans Infectious diseases Major Articles Male Medical sciences Mice Microscopy, Electron Microscopy, Immunoelectron Middle Aged Neutralization Tests Puumala virus RNA, Viral - analysis Urine Viruses Yugoslavia |
| title | Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia |
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