An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

We have used cloned T cell receptor (TCR) genes from closely related CD4 T cell lines to probe the interaction of the TCR with several specific major histocompatibility complex (MHC) class 11 ligands. Complementarity determining region 3 (CDR3) equivalents of both α and β TCR chains are required for...

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Veröffentlicht in:	Cell 1992-06, Vol.69 (6), p.999-1009
Hauptverfasser:	Hong, Soon-Cheol, Chelouche, Adina, Lin, Rong-hwa, Shaywitz, David, Braunstein, Ned S., Glimcher, Laurie, Janeway, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens Antigens - metabolism Base Sequence Binding Sites Biological and medical sciences Clone Cells Conalbumin - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility antigens (hla, h-2 and other systems) Histocompatibility Antigens Class II - metabolism In Vitro Techniques Ligands Mice Mice, Inbred Strains Molecular immunology Molecular Sequence Data Protein Conformation Receptors, Antigen, T-Cell, alpha-beta - chemistry Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Structure-Activity Relationship
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