Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation

Background & Aims: Enterotoxigenic Bacteroides fragilis that secrete a zinc-dependent metalloprotease toxin termed the B. fragilis toxin (BFT) have been associated with acute diarrheal disease. BFT rapidly cleaves the extracellular domain of E-cadherin, leading to the complete degradation of the...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2003-02, Vol.124 (2), p.392-400
Hauptverfasser:	Wu, Shaoguang, Morin, Patrice J., Maouyo, Djik, Sears, Cynthia L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Toxins - pharmacology beta Catenin Biological and medical sciences Biological Transport - drug effects Cell Division - drug effects Cell Nucleus - metabolism Colon - cytology Colon - drug effects Colon - metabolism Cytoplasm - metabolism Cytoskeletal Proteins - metabolism Enterotoxins - pharmacology Human bacterial diseases Humans Infectious diseases Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Medical sciences Metalloendopeptidases - pharmacology Protein Biosynthesis - drug effects Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Signal Transduction - physiology TCF Transcription Factors Tissue Distribution - drug effects Trans-Activators - metabolism Transcription Factor 7-Like 2 Protein Transcription Factors - metabolism Transcription, Genetic - drug effects Tumor Cells, Cultured
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