B-cell subsets and platelet counts in HIV-1 seropositive subjects
A subset of B lymphocytes positive for the CD5 antigen have been implicated in several autoimmune disorders. To investigate their role in human immunodeficiency virus type 1 (HIV-1) infection, we studied peripheral-blood B and T lymphocytes from HIV-1-positive patients with (n=13) and without (n=18)...
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| Veröffentlicht in: | The Lancet (British edition) 1992-06, Vol.339 (8807), p.1445-1446 |
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| creator | Kouri, Y.H. Karpatkin, S. Basch, R.S. |
| description | A subset of B lymphocytes positive for the CD5 antigen have been implicated in several autoimmune disorders. To investigate their role in human immunodeficiency virus type 1 (HIV-1) infection, we studied peripheral-blood B and T lymphocytes from HIV-1-positive patients with (n=13) and without (n=18) thrombocytopenia, 8 patients with classic autoimmune thrombocytopenia, and 16 healthy controls. The proportion of CD5-positive B cells was significantly higher in the HIV-1-positive thrombocytopenic patients than in the healthy controls, as a result of both higher numbers of CD5-positive B cells and lower numbers of CD5-negative B cells. Platelet count was positively correlated with CD5-negative B-cell count (
r=0·6, p |
| doi_str_mv | 10.1016/0140-6736(92)92033-C |
| format | Article |
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r=0·6, p<0·001) and negatively correlated with proportion of B cells that were CD5 positive (
r=-0·5, p<0·01) among the HIV-1-positive patients. The high concentrations of IgM-containing immune complexes in HIV-1-positive patients with autoimmune disorders may be due to changes in the CD5-positive B-cell subset.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(92)92033-C</identifier><identifier>PMID: 1376384</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; AIDS/HIV ; Antigens, CD - analysis ; Autoimmune Diseases - complications ; B-Lymphocyte Subsets ; Biological and medical sciences ; Blood ; CD4 Antigens - analysis ; CD5 Antigens ; Electrocardiography. Vectocardiography ; Electrodiagnosis. Electric activity recording ; Female ; HIV Seropositivity - blood ; HIV-1 ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphocytes ; Male ; Medical research ; Medical sciences ; Platelet Count ; Thrombocytopenia - blood ; Thrombocytopenia - complications</subject><ispartof>The Lancet (British edition), 1992-06, Vol.339 (8807), p.1445-1446</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jun 13, 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-1b0dec6896db84dc566c8c59ef9b69273255ebf5c854fc56a4ab5c2968cd06503</citedby><cites>FETCH-LOGICAL-c459t-1b0dec6896db84dc566c8c59ef9b69273255ebf5c854fc56a4ab5c2968cd06503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199034523?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5450159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1376384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kouri, Y.H.</creatorcontrib><creatorcontrib>Karpatkin, S.</creatorcontrib><creatorcontrib>Basch, R.S.</creatorcontrib><title>B-cell subsets and platelet counts in HIV-1 seropositive subjects</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>A subset of B lymphocytes positive for the CD5 antigen have been implicated in several autoimmune disorders. To investigate their role in human immunodeficiency virus type 1 (HIV-1) infection, we studied peripheral-blood B and T lymphocytes from HIV-1-positive patients with (n=13) and without (n=18) thrombocytopenia, 8 patients with classic autoimmune thrombocytopenia, and 16 healthy controls. The proportion of CD5-positive B cells was significantly higher in the HIV-1-positive thrombocytopenic patients than in the healthy controls, as a result of both higher numbers of CD5-positive B cells and lower numbers of CD5-negative B cells. Platelet count was positively correlated with CD5-negative B-cell count (
r=0·6, p<0·001) and negatively correlated with proportion of B cells that were CD5 positive (
r=-0·5, p<0·01) among the HIV-1-positive patients. The high concentrations of IgM-containing immune complexes in HIV-1-positive patients with autoimmune disorders may be due to changes in the CD5-positive B-cell subset.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antigens, CD - analysis</subject><subject>Autoimmune Diseases - complications</subject><subject>B-Lymphocyte Subsets</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>CD4 Antigens - analysis</subject><subject>CD5 Antigens</subject><subject>Electrocardiography. Vectocardiography</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Female</subject><subject>HIV Seropositivity - blood</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Platelet Count</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - complications</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kEtLxDAUhYMoOj7-gUIREV1Uk-bRZiPo4AsENyruQpreQoZOO-a2A_57U2dQcOEqkPOdy-Ej5JDRC0aZuqRM0FTlXJ3p7FxnlPN0ukEmTOQilSJ_3ySTH2SH7CLOKKVCUblNthnPFS_EhFzfpA6aJsGhROgxsW2VLBrbQwN94rqhjX--TR4e31KWIIRu0aHv_RLGxgxcj_tkq7YNwsH63SOvd7cv04f06fn-cXr9lDohdZ-yklbgVKFVVRaiclIpVzipodal0lnOMymhrKUrpKhjaoUtpcu0KlxFlaR8j5yu7i5C9zEA9mbucdxuW-gGNHmmNdeaRfD4DzjrhtDGbYZpTbmQGY-QWEEudIgBarMIfm7Dp2HUjHrN6M6M7ozOzLdeM421o_XtoZxD9Vta-Yz5yTq36GxTB9s6jz-YFJIyqSN2tcIgClt6CAadh9ZB5UN0aqrO_7_jCyXZlJI</recordid><startdate>19920613</startdate><enddate>19920613</enddate><creator>Kouri, Y.H.</creator><creator>Karpatkin, S.</creator><creator>Basch, R.S.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19920613</creationdate><title>B-cell subsets and platelet counts in HIV-1 seropositive subjects</title><author>Kouri, Y.H. ; Karpatkin, S. ; Basch, R.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-1b0dec6896db84dc566c8c59ef9b69273255ebf5c854fc56a4ab5c2968cd06503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antigens, CD - analysis</topic><topic>Autoimmune Diseases - complications</topic><topic>B-Lymphocyte Subsets</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>CD4 Antigens - analysis</topic><topic>CD5 Antigens</topic><topic>Electrocardiography. Vectocardiography</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Female</topic><topic>HIV Seropositivity - blood</topic><topic>HIV-1</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Platelet Count</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouri, Y.H.</creatorcontrib><creatorcontrib>Karpatkin, S.</creatorcontrib><creatorcontrib>Basch, R.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouri, Y.H.</au><au>Karpatkin, S.</au><au>Basch, R.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B-cell subsets and platelet counts in HIV-1 seropositive subjects</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1992-06-13</date><risdate>1992</risdate><volume>339</volume><issue>8807</issue><spage>1445</spage><epage>1446</epage><pages>1445-1446</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>A subset of B lymphocytes positive for the CD5 antigen have been implicated in several autoimmune disorders. To investigate their role in human immunodeficiency virus type 1 (HIV-1) infection, we studied peripheral-blood B and T lymphocytes from HIV-1-positive patients with (n=13) and without (n=18) thrombocytopenia, 8 patients with classic autoimmune thrombocytopenia, and 16 healthy controls. The proportion of CD5-positive B cells was significantly higher in the HIV-1-positive thrombocytopenic patients than in the healthy controls, as a result of both higher numbers of CD5-positive B cells and lower numbers of CD5-negative B cells. Platelet count was positively correlated with CD5-negative B-cell count (
r=0·6, p<0·001) and negatively correlated with proportion of B cells that were CD5 positive (
r=-0·5, p<0·01) among the HIV-1-positive patients. The high concentrations of IgM-containing immune complexes in HIV-1-positive patients with autoimmune disorders may be due to changes in the CD5-positive B-cell subset.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>1376384</pmid><doi>10.1016/0140-6736(92)92033-C</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult AIDS AIDS/HIV Antigens, CD - analysis Autoimmune Diseases - complications B-Lymphocyte Subsets Biological and medical sciences Blood CD4 Antigens - analysis CD5 Antigens Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Female HIV Seropositivity - blood HIV-1 Humans Investigative techniques, diagnostic techniques (general aspects) Lymphocytes Male Medical research Medical sciences Platelet Count Thrombocytopenia - blood Thrombocytopenia - complications |
| title | B-cell subsets and platelet counts in HIV-1 seropositive subjects |
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