Dialyzed fetal Bovine serum increases cytogenetic fragile X expression

Short‐term whole blood cultures from 9 unrelated male individuals with the fragile X [fra(X)] syndrome were exposed to 5‐fluorodeoxyuridine (FUdR). The fra(X) frequency was higher in 8 of 9 cases where the complete medium contained dialyzed fetal bovine serum (DFBS). In 3 of the cases, the fra(X) fr...

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Veröffentlicht in:	American journal of medical genetics 1992-04, Vol.43 (1-2), p.155-160
Hauptverfasser:	Jenkins, Edmund C., Duncan, Charlotte J., Gu, Hong, Genovese, Marilyn, Krawczun, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorodeoxyuridine Animals Blood Cattle Culture Media Cytogenetics - methods Dialysis dialyzed fetal bovine serum fetal bovine serum Floxuridine Folic Acid fra(X) frequency Fragile X Syndrome - diagnosis Fragile X Syndrome - genetics FUdR Humans Male mitotic index X chromosome X-linked mental retardation
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