Novel inclusion bodies in Betz cells of cortical area 4 of aged rhesus monkeys
Seven adult rhesus monkeys ranging in age from 5 to 35 years were studied in an ultrastructural investigation of cortical area 4. Some Betz cells of layer 5 contained a perikaryal inclusion body (IB) of a unique and characteristic ultrastructural configuration that has not previously been described....
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| Veröffentlicht in: | The Anatomical record 1992-05, Vol.233 (1), p.162-168 |
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| container_title | The Anatomical record |
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| creator | Tigges, Johannes |
| description | Seven adult rhesus monkeys ranging in age from 5 to 35 years were studied in an ultrastructural investigation of cortical area 4. Some Betz cells of layer 5 contained a perikaryal inclusion body (IB) of a unique and characteristic ultrastructural configuration that has not previously been described. The IBs consist of a regular array of three sets of equidistant parallel sheets and are not membrane bound. The distance between the sheets measures ∼ 80 nm. The three sets of sheets intersect at an invariable angle of 60°, forming a regular geometric structure. Each sheet comprises a single layer of parallel and densely packed straight filaments, which are ∼10 nm thick. Thus the IBs present highly ordered crystalline arrays of filaments. The occurrence and number of IBs may be age related, since they appeared only in monkeys in mid to late adulthood and were most numerous in the oldest monkey. © 1992 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ar.1092330119 |
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Some Betz cells of layer 5 contained a perikaryal inclusion body (IB) of a unique and characteristic ultrastructural configuration that has not previously been described. The IBs consist of a regular array of three sets of equidistant parallel sheets and are not membrane bound. The distance between the sheets measures ∼ 80 nm. The three sets of sheets intersect at an invariable angle of 60°, forming a regular geometric structure. Each sheet comprises a single layer of parallel and densely packed straight filaments, which are ∼10 nm thick. Thus the IBs present highly ordered crystalline arrays of filaments. The occurrence and number of IBs may be age related, since they appeared only in monkeys in mid to late adulthood and were most numerous in the oldest monkey. © 1992 Wiley‐Liss, Inc.</description><subject>Aging - pathology</subject><subject>Anatomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inclusion Bodies - ultrastructure</subject><subject>Intermediate Filaments - ultrastructure</subject><subject>Macaca mulatta - anatomy & histology</subject><subject>Microscopy, Electron</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0003-276X</issn><issn>1097-0185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo67p69CjkIN6qSZM0yXFd_IJlBVHwVtJ0qtW2WZOtsv71tnRxPXl6zJsfb4aH0DEl55SQ-ML4TnXMGKFU76BxN8iIUCV20ZgQwqJYJs_76CCEN9IhPElGaEQZVQlnY7RYuE-ocNnYqg2la3Dm8hJCZ-BLWH1jC1UVsCuwdX5VWlNh48Fg3lvmBXLsXyG0AdeueYd1OER7hakCHG10gp6urx5nt9H8_uZuNp1HliVCR8IkidGZEUQpLSiXihiVEU4LFWtREC4U1wKkVpBLyC0kWjDKMpUTTWOwbILOhtyldx8thFVal6H_1TTg2pDKWGtGJe_AaACtdyF4KNKlL2vj1yklad9fany67a_jTzbBbVZDvqWHwrr96WZvQtdG4U1jy_CLccEUkX2MHLCvsoL1_zfT6cOfB34AQlKFtQ</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Tigges, Johannes</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Novel inclusion bodies in Betz cells of cortical area 4 of aged rhesus monkeys</title><author>Tigges, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3659-5a66a9ba50889514780a8b041f8295f0458495e798ed7edce695313b8d0912ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aging - pathology</topic><topic>Anatomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inclusion Bodies - ultrastructure</topic><topic>Intermediate Filaments - ultrastructure</topic><topic>Macaca mulatta - anatomy & histology</topic><topic>Microscopy, Electron</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>online_resources</toplevel><creatorcontrib>Tigges, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Anatomical record</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tigges, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel inclusion bodies in Betz cells of cortical area 4 of aged rhesus monkeys</atitle><jtitle>The Anatomical record</jtitle><addtitle>Anat Rec</addtitle><date>1992-05</date><risdate>1992</risdate><volume>233</volume><issue>1</issue><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>0003-276X</issn><eissn>1097-0185</eissn><coden>ANREAK</coden><abstract>Seven adult rhesus monkeys ranging in age from 5 to 35 years were studied in an ultrastructural investigation of cortical area 4. Some Betz cells of layer 5 contained a perikaryal inclusion body (IB) of a unique and characteristic ultrastructural configuration that has not previously been described. The IBs consist of a regular array of three sets of equidistant parallel sheets and are not membrane bound. The distance between the sheets measures ∼ 80 nm. The three sets of sheets intersect at an invariable angle of 60°, forming a regular geometric structure. Each sheet comprises a single layer of parallel and densely packed straight filaments, which are ∼10 nm thick. Thus the IBs present highly ordered crystalline arrays of filaments. The occurrence and number of IBs may be age related, since they appeared only in monkeys in mid to late adulthood and were most numerous in the oldest monkey. © 1992 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1318643</pmid><doi>10.1002/ar.1092330119</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Anatomical record, 1992-05, Vol.233 (1), p.162-168 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aging - pathology Anatomy Animals Biological and medical sciences Central nervous system Cerebral Cortex - cytology Cerebral Cortex - ultrastructure Fundamental and applied biological sciences. Psychology Inclusion Bodies - ultrastructure Intermediate Filaments - ultrastructure Macaca mulatta - anatomy & histology Microscopy, Electron Vertebrates: nervous system and sense organs |
| title | Novel inclusion bodies in Betz cells of cortical area 4 of aged rhesus monkeys |
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