Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobichydrophobic- or -aromaticpro- cleavage sites

The sequence requirements for HIV-1 proteinase catalyzed cleavage of oligopeptides containing two distinct types of junctions (-hydrophobic*hydrophobic- or -aromatic*Pro-) has been investigated. For the first type of junction (-hydrophobic*hydrophobic-) the optimal residues in the P2 and P2' po...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 1992-06, Vol.31 (22), p.5193-5200
Hauptverfasser:	Griffiths, J T, Phylip, L H, Konvalinka, J, Strop, P, Gustchina, A, Wlodawer, A, Davenport, R J, Briggs, R, Dunn, B M, Kay, J
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Amino Acids - metabolism Binding Sites HIV Protease - chemistry HIV Protease - metabolism HIV-1 - enzymology Hydrolysis Molecular Sequence Data Protein Conformation Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!