Effect of dexamethasone on nucleolar casein kinase II activity and phosphorylation of nucleolin in lymphosarcoma P1798 cells

Ribosomal RNA (rRNA) synthesis in murine P1798 lymphosarcoma cells is reversibly inhibited by glucocorticoids. The effects of dexamethasone upon nucleolin phosphorylation and upon the amount and activity of casein kinase II have been examined. P1798 cells were exposed to 0.1 μM dexamethasone for 36...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1992-05, Vol.42 (3), p.305-312
Hauptverfasser:	Suzuki, Noriaki, Suzuki, Toshikazu, Uchida, Aoi, Thompson, E.Aubrey, Hosoya, Toichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Casein Kinase II Cell Nucleolus - enzymology Cells, Cultured Cycloheximide - pharmacology Dexamethasone - pharmacology DNA - biosynthesis Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology In Vitro Techniques Mice Nuclear Proteins - metabolism Nucleolin Phosphoproteins - metabolism Phosphorylation Protein Serine-Threonine Kinases - metabolism RNA, Ribosomal - biosynthesis RNA-Binding Proteins Transferases
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