Simulation of the solution structure of the H-ras p21-GTP complex

An unconstrained simulation of the GTP-bound form of the H-ras protein p21 is performed in an aqueous environment with charge-neutralizing counterions. The simulation is compared to the 1.35-A structure of Pai et al. [(1990) EMBO J. 9, 2351] and a proposed alternate structure, in which the loop at r...

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Veröffentlicht in:	Biochemistry (Easton) 1992-06, Vol.31 (21), p.4951-4959
Hauptverfasser:	Foley, C. K., Pedersen, L. G., Charifson, P. S., Darden, T. A., Wittinghofer, A., Pai, E. F., Anderson, M. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Computer Simulation Crystallography Fundamental and applied biological sciences. Psychology Guanosine Triphosphate - chemistry Models, Molecular Molecular biophysics Molecular Sequence Data Oncogene Protein p21(ras) - chemistry Solutions Structure in molecular biology Tridimensional structure
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