The development of cytotoxicity in peritoneal macrophages from women with endometriosis
To assess the activation status of peritoneal macrophages from women with endometriosis. Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line. Patients were tested at initial laparoscopy or at the completion of therapy....
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| Veröffentlicht in: | Fertility and sterility 1992-06, Vol.57 (6), p.1203-1210 |
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| container_title | Fertility and sterility |
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| creator | Braun, Donald P. Gebel, Howard Rotman, Carlos Rana, Nasir Dmowski, W. Paul |
| description | To assess the activation status of peritoneal macrophages from women with endometriosis.
Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line.
Patients were tested at initial laparoscopy or at the completion of therapy.
Fertile controls (n=27), infertile controls (n=20), untreated endometriosis (n=43), danazol-treated endometriosis (n=22), and gonadotropin-releasing hormone agonist (GnRH-a)-treated endometriosis (n=13) were tested.
Danazol (800mg/d) or GnRH-a therapy for 6months.
Cytotoxicity was elevated in stage I and II endometriosis (P |
| doi_str_mv | 10.1016/S0015-0282(16)55074-2 |
| format | Article |
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Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line.
Patients were tested at initial laparoscopy or at the completion of therapy.
Fertile controls (n=27), infertile controls (n=20), untreated endometriosis (n=43), danazol-treated endometriosis (n=22), and gonadotropin-releasing hormone agonist (GnRH-a)-treated endometriosis (n=13) were tested.
Danazol (800mg/d) or GnRH-a therapy for 6months.
Cytotoxicity was elevated in stage I and II endometriosis (P<0.02) and in infertile controls (P<0.05) compared with fertile controls. Cytotoxicity in stage III and IV endometriosis was lower (P<0.02) than in stage I and II endometriosis. Indomethacin in vitro increased cytotoxicity (P<0.05) in stage III and IV endometriosis but not in the other groups tested. Cytotoxicity in danazol or GnRH-a-treated patients was increased (P<0.05 or greater) compared with untreated patients with comparable stage of disease.
Peritoneal macrophage cytotoxicity in women with endometriosis is affected by (1) the extent of endometriosis, (2) prostaglandin metabolism, and (3) treatment with danazol or GnRH-a.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)55074-2</identifier><identifier>PMID: 1601140</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; cytotoxicity in endometriosis ; Cytotoxicity, Immunologic - drug effects ; Danazol - therapeutic use ; Endometriosis - drug therapy ; Endometriosis - immunology ; Female ; Female genital diseases ; Fertility ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - therapeutic use ; Gynecology. Andrology. Obstetrics ; Humans ; Indomethacin - pharmacology ; indomethacin effects on macrophages ; Infertility, Female - immunology ; Macrophages ; Macrophages - immunology ; Medical sciences ; Non tumoral diseases ; Peritoneal Cavity - cytology ; prostaglandins ; Reference Values ; Triptorelin Pamoate - analogs & derivatives</subject><ispartof>Fertility and sterility, 1992-06, Vol.57 (6), p.1203-1210</ispartof><rights>1992 American Society for Reproductive Medicine</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-371bc04c7f86f770cca3bad43d107b13c63814d2bb6aaeaacc61c79d56166bb03</citedby><cites>FETCH-LOGICAL-c436t-371bc04c7f86f770cca3bad43d107b13c63814d2bb6aaeaacc61c79d56166bb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)55074-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3538,23912,23913,25122,27906,27907,45977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5432512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1601140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, Donald P.</creatorcontrib><creatorcontrib>Gebel, Howard</creatorcontrib><creatorcontrib>Rotman, Carlos</creatorcontrib><creatorcontrib>Rana, Nasir</creatorcontrib><creatorcontrib>Dmowski, W. Paul</creatorcontrib><title>The development of cytotoxicity in peritoneal macrophages from women with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To assess the activation status of peritoneal macrophages from women with endometriosis.
Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line.
Patients were tested at initial laparoscopy or at the completion of therapy.
Fertile controls (n=27), infertile controls (n=20), untreated endometriosis (n=43), danazol-treated endometriosis (n=22), and gonadotropin-releasing hormone agonist (GnRH-a)-treated endometriosis (n=13) were tested.
Danazol (800mg/d) or GnRH-a therapy for 6months.
Cytotoxicity was elevated in stage I and II endometriosis (P<0.02) and in infertile controls (P<0.05) compared with fertile controls. Cytotoxicity in stage III and IV endometriosis was lower (P<0.02) than in stage I and II endometriosis. Indomethacin in vitro increased cytotoxicity (P<0.05) in stage III and IV endometriosis but not in the other groups tested. Cytotoxicity in danazol or GnRH-a-treated patients was increased (P<0.05 or greater) compared with untreated patients with comparable stage of disease.
Peritoneal macrophage cytotoxicity in women with endometriosis is affected by (1) the extent of endometriosis, (2) prostaglandin metabolism, and (3) treatment with danazol or GnRH-a.</description><subject>Biological and medical sciences</subject><subject>cytotoxicity in endometriosis</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Danazol - therapeutic use</subject><subject>Endometriosis - drug therapy</subject><subject>Endometriosis - immunology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fertility</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - therapeutic use</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Indomethacin - pharmacology</subject><subject>indomethacin effects on macrophages</subject><subject>Infertility, Female - immunology</subject><subject>Macrophages</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Peritoneal Cavity - cytology</subject><subject>prostaglandins</subject><subject>Reference Values</subject><subject>Triptorelin Pamoate - analogs & derivatives</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TyASE4BDx2bO-eUFXxJVXiQBFHyxlPWKMkDra3Zf892e6qHDmNRvO8M_bD2AWItyDAvPsmBOhGyLV8DeaN1sK2jXzEVqC1abTR6jFbPSBP2bNSfgkhDFh5xs7ACIBWrNiPmy3xQLc0pHmkqfLUc9zXVNOfiLHueZz4TDnWNJEf-Ogxp3nrf1LhfU4jv0tLit_FuuU0haWpOaYSy3P2pPdDoRenes6-f_xwc_W5uf766cvV5XWDrTK1URY6FC3afm16awWiV50PrQogbAcKjVpDG2TXGe_Je0QDaDdBGzCm64Q6Z6-Oe-ecfu-oVDfGgjQMfqK0K87KzUYYaRdQH8HlA6Vk6t2c4-jz3oFwB6HuXqg72HJLdy_UySV3cTqw60YK_1JHg8v85WnuC_qhz37CWB4w3Sqp4bDm_RGjRcZtpOwKRpqQQsyE1YUU__OQv5GNk5w</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Braun, Donald P.</creator><creator>Gebel, Howard</creator><creator>Rotman, Carlos</creator><creator>Rana, Nasir</creator><creator>Dmowski, W. Paul</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>The development of cytotoxicity in peritoneal macrophages from women with endometriosis</title><author>Braun, Donald P. ; Gebel, Howard ; Rotman, Carlos ; Rana, Nasir ; Dmowski, W. Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-371bc04c7f86f770cca3bad43d107b13c63814d2bb6aaeaacc61c79d56166bb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>cytotoxicity in endometriosis</topic><topic>Cytotoxicity, Immunologic - drug effects</topic><topic>Danazol - therapeutic use</topic><topic>Endometriosis - drug therapy</topic><topic>Endometriosis - immunology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fertility</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - therapeutic use</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Indomethacin - pharmacology</topic><topic>indomethacin effects on macrophages</topic><topic>Infertility, Female - immunology</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Peritoneal Cavity - cytology</topic><topic>prostaglandins</topic><topic>Reference Values</topic><topic>Triptorelin Pamoate - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Donald P.</creatorcontrib><creatorcontrib>Gebel, Howard</creatorcontrib><creatorcontrib>Rotman, Carlos</creatorcontrib><creatorcontrib>Rana, Nasir</creatorcontrib><creatorcontrib>Dmowski, W. Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Donald P.</au><au>Gebel, Howard</au><au>Rotman, Carlos</au><au>Rana, Nasir</au><au>Dmowski, W. Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The development of cytotoxicity in peritoneal macrophages from women with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>57</volume><issue>6</issue><spage>1203</spage><epage>1210</epage><pages>1203-1210</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To assess the activation status of peritoneal macrophages from women with endometriosis.
Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line.
Patients were tested at initial laparoscopy or at the completion of therapy.
Fertile controls (n=27), infertile controls (n=20), untreated endometriosis (n=43), danazol-treated endometriosis (n=22), and gonadotropin-releasing hormone agonist (GnRH-a)-treated endometriosis (n=13) were tested.
Danazol (800mg/d) or GnRH-a therapy for 6months.
Cytotoxicity was elevated in stage I and II endometriosis (P<0.02) and in infertile controls (P<0.05) compared with fertile controls. Cytotoxicity in stage III and IV endometriosis was lower (P<0.02) than in stage I and II endometriosis. Indomethacin in vitro increased cytotoxicity (P<0.05) in stage III and IV endometriosis but not in the other groups tested. Cytotoxicity in danazol or GnRH-a-treated patients was increased (P<0.05 or greater) compared with untreated patients with comparable stage of disease.
Peritoneal macrophage cytotoxicity in women with endometriosis is affected by (1) the extent of endometriosis, (2) prostaglandin metabolism, and (3) treatment with danazol or GnRH-a.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1601140</pmid><doi>10.1016/S0015-0282(16)55074-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences cytotoxicity in endometriosis Cytotoxicity, Immunologic - drug effects Danazol - therapeutic use Endometriosis - drug therapy Endometriosis - immunology Female Female genital diseases Fertility Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - therapeutic use Gynecology. Andrology. Obstetrics Humans Indomethacin - pharmacology indomethacin effects on macrophages Infertility, Female - immunology Macrophages Macrophages - immunology Medical sciences Non tumoral diseases Peritoneal Cavity - cytology prostaglandins Reference Values Triptorelin Pamoate - analogs & derivatives |
| title | The development of cytotoxicity in peritoneal macrophages from women with endometriosis |
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