Brucella abortus stimulates human T cells from uninfected and HIV-infected individuals to secrete IFN gamma: implications for use of Brucella abortus as a carrier in development of human vaccines

Brucella abortus has been characterized as a T-independent type 1 antigen/carrier in human and murine antibody responses. In this report it is shown that BA can activate human CD3+ T cells to secrete interferon-gamma (IFN gamma). Unlike mitogens, such as phytohemagglutinin, this stimulation was asso...

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Veröffentlicht in:	AIDS research and human retroviruses 1992-04, Vol.8 (4), p.479-486
Hauptverfasser:	Blay, R, Hernandez, D, Betts, M, Clerici, M, Lucey, D R, Hendrix, C, Hoffman, T, Golding, B
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Brucella abortus Brucella abortus - immunology CD4-Positive T-Lymphocytes - immunology CD8 Antigens - immunology Cells, Cultured Enzyme-Linked Immunosorbent Assay HIV Infections - immunology Humans Interferon-gamma - secretion Monocytes - immunology Receptors, Interleukin-2 - biosynthesis T-Lymphocytes - immunology T-Lymphocytes - secretion Viral Vaccines - immunology
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