Intraventricular 5,7-dihydroxytryptamine lesions disrupt acquisition of working memory task rules but not performance once learned

The serotonergic system is implicated in learning and memory and its disorder, e.g. after 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) abuse. This study examined the effects of widespread depletion of serotonin (5-HT) using intraventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) on th...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2003-02, Vol.27 (1), p.147-156
Hauptverfasser:	Cassaday, Helen J, Norman, Christine, Shilliam, Claire S, Vincent, Christine, Marsden, Charles A
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7-Dihydroxytryptamine - administration & dosage 5,7-Dihydroxytryptamine - pharmacology Animal Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Injections, Intraventricular Learning Learning. Memory Male Maze Learning - drug effects Memory - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Serotonin - metabolism Serotonin Agents - administration & dosage Serotonin Agents - pharmacology Serotonin depletion Working memory
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