Maintenance of sympathetic tone by a nickel chloride-sensitive mechanism in the rostral ventrolateral medulla of the adult rat

In urethane-anaesthetised artificially ventilated Sprague–Dawley rats, bilateral microinjection of the divalent cation nickel chloride (Ni 2+; 50 mM, 50 nl) into the rostral ventrolateral medulla elicited a dramatic inhibition of splanchnic sympathetic nerve activity (−44±6%) and a marked depressor...

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Veröffentlicht in:	Neuroscience 2003-01, Vol.116 (2), p.455-464
Hauptverfasser:	Miyawaki, T, Goodchild, A.K, Pilowsky, P.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals baroreceptor reflex Baroreflex - drug effects Baroreflex - physiology Biological and medical sciences blood pressure Blood Pressure - drug effects Blood Pressure - physiology brainstem Calcium Channel Blockers - pharmacology Calcium Channels, T-Type - physiology caudal ventrolateral medulla Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology in vivo Kynurenic Acid - pharmacology Male Medulla Oblongata - drug effects Medulla Oblongata - physiology Membrane Potentials - drug effects Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Nickel - pharmacology Rats Rats, Sprague-Dawley rostral ventrolateral medulla Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs
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