Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins
Cross-protection between different subtypes of influenza A virus has been attributed to heterosubtypic immunity (HSI). Although, HSI can occur in the absence of anti-HA or anti-NA antibodies, HSI seems to be mediated, in part, by cross-reactive antibodies. In this study, we examined the effects of a...
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| Veröffentlicht in: | Vaccine 2003-02, Vol.21 (9), p.902-914 |
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| creator | Mitchell, Judy A. Green, Thomas D. Bright, Rick A. Ross, Ted M. |
| description | Cross-protection between different subtypes of influenza A virus has been attributed to heterosubtypic immunity (HSI). Although, HSI can occur in the absence of anti-HA or anti-NA antibodies, HSI seems to be mediated, in part, by cross-reactive antibodies. In this study, we examined the effects of a DNA vaccine expressing an influenza HA fused to three copies of murine C3d of complement (HA–mC3d
3). HA–mC3d
3 elicited heterosubtypic immunity more efficiently than non-fused forms of HA and protected mice from lethal challenge of influenza with different subtypes. Plasmid encoding for various forms of HA were constructed from two influenza strains, A/Puerto Rico/8/34 (H1N1) or A/Aichi/2/68-x31 (H3N2). Vaccinated mice were analyzed for enhancement of anti-HA titers, affinity maturation of antibody, hemagglutinin-inhibition activity, and altered cytokine profiles. The HA–mC3d
3–DNA vaccinated mice were protected from heterologous influenza challenge, even though sera from these mice had no viral-neutralizing activity against heterologous virus. |
| doi_str_mv | 10.1016/S0264-410X(02)00539-X |
| format | Article |
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3). HA–mC3d
3 elicited heterosubtypic immunity more efficiently than non-fused forms of HA and protected mice from lethal challenge of influenza with different subtypes. Plasmid encoding for various forms of HA were constructed from two influenza strains, A/Puerto Rico/8/34 (H1N1) or A/Aichi/2/68-x31 (H3N2). Vaccinated mice were analyzed for enhancement of anti-HA titers, affinity maturation of antibody, hemagglutinin-inhibition activity, and altered cytokine profiles. The HA–mC3d
3–DNA vaccinated mice were protected from heterologous influenza challenge, even though sera from these mice had no viral-neutralizing activity against heterologous virus.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(02)00539-X</identifier><identifier>PMID: 12547601</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibodies ; Antibodies, Viral - biosynthesis ; B lymphocytes ; Biological and medical sciences ; Cell Line ; Complement C3d - genetics ; Cytokines - biosynthesis ; Cytomegalovirus ; Deoxyribonucleic acid ; DNA ; Female ; Fundamental and applied biological sciences. Psychology ; Growth hormones ; Hemagglutinin Glycoproteins, Influenza Virus - genetics ; Humans ; In Vitro Techniques ; Influenza ; Influenza A virus ; Influenza A virus - classification ; Influenza A virus - genetics ; Influenza A virus - immunology ; Influenza Vaccines - genetics ; Influenza Vaccines - pharmacology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Lymphocytes ; Mice ; Mice, Inbred BALB C ; Microbiology ; Morbidity ; Mortality ; Neutralization Tests ; Plasmids ; Plasmids - genetics ; Proteins ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - immunology ; Streptococcus infections ; Studies ; Transfection ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, DNA - genetics ; Vaccines, DNA - pharmacology ; Virology</subject><ispartof>Vaccine, 2003-02, Vol.21 (9), p.902-914</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 14, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-6714afbcc2a9c17787c5f3fc63509a96fede4b4f518ef38a3d79c7b404f4e62f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1490973943?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14733799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12547601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchell, Judy A.</creatorcontrib><creatorcontrib>Green, Thomas D.</creatorcontrib><creatorcontrib>Bright, Rick A.</creatorcontrib><creatorcontrib>Ross, Ted M.</creatorcontrib><title>Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Cross-protection between different subtypes of influenza A virus has been attributed to heterosubtypic immunity (HSI). Although, HSI can occur in the absence of anti-HA or anti-NA antibodies, HSI seems to be mediated, in part, by cross-reactive antibodies. In this study, we examined the effects of a DNA vaccine expressing an influenza HA fused to three copies of murine C3d of complement (HA–mC3d
3). HA–mC3d
3 elicited heterosubtypic immunity more efficiently than non-fused forms of HA and protected mice from lethal challenge of influenza with different subtypes. Plasmid encoding for various forms of HA were constructed from two influenza strains, A/Puerto Rico/8/34 (H1N1) or A/Aichi/2/68-x31 (H3N2). Vaccinated mice were analyzed for enhancement of anti-HA titers, affinity maturation of antibody, hemagglutinin-inhibition activity, and altered cytokine profiles. The HA–mC3d
3–DNA vaccinated mice were protected from heterologous influenza challenge, even though sera from these mice had no viral-neutralizing activity against heterologous virus.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Complement C3d - genetics</subject><subject>Cytokines - biosynthesis</subject><subject>Cytomegalovirus</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth hormones</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - genetics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Influenza</subject><subject>Influenza A virus</subject><subject>Influenza A virus - classification</subject><subject>Influenza A virus - genetics</subject><subject>Influenza A virus - immunology</subject><subject>Influenza Vaccines - genetics</subject><subject>Influenza Vaccines - pharmacology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neutralization Tests</subject><subject>Plasmids</subject><subject>Plasmids - genetics</subject><subject>Proteins</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>Streptococcus infections</subject><subject>Studies</subject><subject>Transfection</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - pharmacology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0U1vFCEYB3BiNHatfgQNidHUwygMDAwn06xvTRo9qMneCMM8bGlmmBWGxu2nl32JTTzYCyTwe3iAP0LPKXlLCRXvvpNa8IpTsjoj9RtCGqaq1QO0oK1kVd3Q9iFa_CUn6ElK12SnqHqMTmjdcCkIXaDbi9BnO_sp4MnhK5ghTil383bjLfbjmIOft3iesA9uyBBuDT7HNz7mhHPyYY0N_vC1rBhrfQAMvzcR0n7jCkazXg959sGHasl67EpF6bOJ0ww-pKfokTNDgmfH-RT9_PTxx_JLdfnt88Xy_LKyvGVzJSTlxnXW1kZZKmUrbeOYs4I1RBklHPTAO-7Kk8Gx1rBeKis7TrjjIGrHTtHrw7ml8a8MadajTxaGwQSYctKyVm0rhbgX0lYIzmlT4Nn_YUOIVLKMhb78h15POYbyXk25IkoyxVlRzUHZ8vspgtOb6EcTt5oSvYtb7-PWuyw1qfU-br0qdS-Op-duhP6u6phvAa-OwCRrBhdNsD7dOS4Zk0oV9_7goARx4yHqZD0EC72PYGfdT_6eq_wB2W7Igg</recordid><startdate>20030214</startdate><enddate>20030214</enddate><creator>Mitchell, Judy A.</creator><creator>Green, Thomas D.</creator><creator>Bright, Rick A.</creator><creator>Ross, Ted M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7TM</scope><scope>7U2</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030214</creationdate><title>Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins</title><author>Mitchell, Judy A. ; Green, Thomas D. ; Bright, Rick A. ; Ross, Ted M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-6714afbcc2a9c17787c5f3fc63509a96fede4b4f518ef38a3d79c7b404f4e62f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Complement C3d - genetics</topic><topic>Cytokines - biosynthesis</topic><topic>Cytomegalovirus</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth hormones</topic><topic>Hemagglutinin Glycoproteins, Influenza Virus - genetics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Influenza</topic><topic>Influenza A virus</topic><topic>Influenza A virus - classification</topic><topic>Influenza A virus - genetics</topic><topic>Influenza A virus - immunology</topic><topic>Influenza Vaccines - genetics</topic><topic>Influenza Vaccines - pharmacology</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - prevention & control</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neutralization Tests</topic><topic>Plasmids</topic><topic>Plasmids - genetics</topic><topic>Proteins</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>Streptococcus infections</topic><topic>Studies</topic><topic>Transfection</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, DNA - genetics</topic><topic>Vaccines, DNA - pharmacology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Judy A.</creatorcontrib><creatorcontrib>Green, Thomas D.</creatorcontrib><creatorcontrib>Bright, Rick A.</creatorcontrib><creatorcontrib>Ross, Ted M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Nucleic Acids Abstracts</collection><collection>Safety Science and Risk</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Judy A.</au><au>Green, Thomas D.</au><au>Bright, Rick A.</au><au>Ross, Ted M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2003-02-14</date><risdate>2003</risdate><volume>21</volume><issue>9</issue><spage>902</spage><epage>914</epage><pages>902-914</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Cross-protection between different subtypes of influenza A virus has been attributed to heterosubtypic immunity (HSI). Although, HSI can occur in the absence of anti-HA or anti-NA antibodies, HSI seems to be mediated, in part, by cross-reactive antibodies. In this study, we examined the effects of a DNA vaccine expressing an influenza HA fused to three copies of murine C3d of complement (HA–mC3d
3). HA–mC3d
3 elicited heterosubtypic immunity more efficiently than non-fused forms of HA and protected mice from lethal challenge of influenza with different subtypes. Plasmid encoding for various forms of HA were constructed from two influenza strains, A/Puerto Rico/8/34 (H1N1) or A/Aichi/2/68-x31 (H3N2). Vaccinated mice were analyzed for enhancement of anti-HA titers, affinity maturation of antibody, hemagglutinin-inhibition activity, and altered cytokine profiles. The HA–mC3d
3–DNA vaccinated mice were protected from heterologous influenza challenge, even though sera from these mice had no viral-neutralizing activity against heterologous virus.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12547601</pmid><doi>10.1016/S0264-410X(02)00539-X</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Antibodies Antibodies, Viral - biosynthesis B lymphocytes Biological and medical sciences Cell Line Complement C3d - genetics Cytokines - biosynthesis Cytomegalovirus Deoxyribonucleic acid DNA Female Fundamental and applied biological sciences. Psychology Growth hormones Hemagglutinin Glycoproteins, Influenza Virus - genetics Humans In Vitro Techniques Influenza Influenza A virus Influenza A virus - classification Influenza A virus - genetics Influenza A virus - immunology Influenza Vaccines - genetics Influenza Vaccines - pharmacology Influenza, Human - immunology Influenza, Human - prevention & control Lymphocytes Mice Mice, Inbred BALB C Microbiology Morbidity Mortality Neutralization Tests Plasmids Plasmids - genetics Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Streptococcus infections Studies Transfection Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - genetics Vaccines, DNA - pharmacology Virology |
| title | Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins |
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