Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24

We conducted a genome scan using a 10-cM map to search for genes linked to type 2 diabetes in 691 individuals from a founder population, the Old Order Amish. We then saturated two regions on chromosomes 1 and 14 showing promising linkage signals with additional markers to produce a approximately 2-c...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2003-02, Vol.52 (2), p.550-557
Hauptverfasser:	Hsueh, Wen-Chi, St Jean, Pamela L, Mitchell, Braxton D, Pollin, Toni I, Knowler, William C, Ehm, Margaret G, Bell, Callum J, Sakul, Hakan, Wagner, Michael J, Burns, Daniel K, Shuldiner, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amish Blood Glucose - metabolism Chromosome Mapping - methods Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 14 Demographic aspects Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes research Diseases Ethnic Groups - genetics Female Genetic aspects Genetic Linkage Genetic research Genome, Human Humans Lod Score Male Middle Aged Quantitative Trait Loci - genetics Sensitivity and Specificity Statistics Type 2 diabetes United States
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