The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus
l-Carnitine and its esters are products of intermediary metabolism of organisms. The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospr...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2003-01, Vol.375 (2), p.200-210 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Möder, M Kiessling, A Löster, H Brüggemann, L |
| description | l-Carnitine and its esters are products of intermediary metabolism of organisms. The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospray ionization (ESI)-mass spectrometry (MS) is presented. Groups of healthy probands and patients suffering from diabetes mellitus were investigated due to their significant acylcarnitine profile. The statistical analysis of data sets obtained clearly shows a difference in the acylcarnitine pattern of healthy and sick probands. In comparison to the controls, diabetes mellitus patients excrete more long-chain carnitine esters ranging from dodecanoyl to palmitoylcarnitine. Thus, the urinary acylcarnitine pattern determined by ESI-MS can be a useful tool in the diagnosis and therapy monitoring of diabetes mellitus. |
| doi_str_mv | 10.1007/s00216-002-1654-7 |
| format | Article |
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The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospray ionization (ESI)-mass spectrometry (MS) is presented. Groups of healthy probands and patients suffering from diabetes mellitus were investigated due to their significant acylcarnitine profile. The statistical analysis of data sets obtained clearly shows a difference in the acylcarnitine pattern of healthy and sick probands. In comparison to the controls, diabetes mellitus patients excrete more long-chain carnitine esters ranging from dodecanoyl to palmitoylcarnitine. 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Thus, the urinary acylcarnitine pattern determined by ESI-MS can be a useful tool in the diagnosis and therapy monitoring of diabetes mellitus.</description><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>Calibration</subject><subject>Carnitine - analogs & derivatives</subject><subject>Carnitine - urine</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - urine</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><issn>1618-2642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLlOxDAQhl2AYDkegAa5ogv4SJyEDq24pJVooLYcewJGufA4Qul5cLzsShQee0b__OP5CLng7JozVt4gY4KrLMWMqyLPygOy4opXmVC5OCYniJ-M8aLi6ogcc1EoViu5Ij-vH0AnEyOEgY4tnYMfTFiosUtnTRh89AMgdZAEfXo62iwUOrAxjDgFs9DeIFKc_io9xLDcUkMH-KZxHDvqBxrTBOfN-zCix-2MlDTJD2kPXefjjGfksDUdwvn-PiVvD_ev66ds8_L4vL7bZFbmRczKFuqyYa3JXQ7CKWmEdKZIW5V1rYQC14CtKm5r3lZKcmaNgloUMpeiFk7IU3K1853C-DUDRt17tOkTZoBxRl2KukpHJiHfCW3aEgO0egq-T1w0Z3qLW-9w6xT1FrcuU8_l3nxuenD_HXvW8hd8pn_e</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Möder, M</creator><creator>Kiessling, A</creator><creator>Löster, H</creator><creator>Brüggemann, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus</title><author>Möder, M ; Kiessling, A ; Löster, H ; Brüggemann, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-7fe97b0fa4d4e2d63a23da5015799626edbec881c91f86310ca6e925343292d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>Calibration</topic><topic>Carnitine - analogs & derivatives</topic><topic>Carnitine - urine</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - urine</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Möder, M</creatorcontrib><creatorcontrib>Kiessling, A</creatorcontrib><creatorcontrib>Löster, H</creatorcontrib><creatorcontrib>Brüggemann, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Möder, M</au><au>Kiessling, A</au><au>Löster, H</au><au>Brüggemann, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><addtitle>Anal Bioanal Chem</addtitle><date>2003-01</date><risdate>2003</risdate><volume>375</volume><issue>2</issue><spage>200</spage><epage>210</epage><pages>200-210</pages><issn>1618-2642</issn><abstract>l-Carnitine and its esters are products of intermediary metabolism of organisms. 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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Body Mass Index Calibration Carnitine - analogs & derivatives Carnitine - urine Diabetes Mellitus - diagnosis Diabetes Mellitus - urine Humans Middle Aged Spectrometry, Mass, Electrospray Ionization - methods |
| title | The pattern of urinary acylcarnitines determined by electrospray mass spectrometry: a new tool in the diagnosis of diabetes mellitus |
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