The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans

We have cloned the Candida albicans TPK2 gene encoding a cAMP-dependent protein kinase (PKA) catalytic subunit and generated a tpk2 homozygous null mutant to assess its ability to germinate in liquid media. N-acetylglucosamine (GlcNAc)-induced germ-tube formation was attenuated in the tpk2 strain an...

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Veröffentlicht in:	Fungal genetics and biology 2003-02, Vol.38 (1), p.133-141
Hauptverfasser:	Cloutier, Monikca, Castilla, Rocı́o, Bolduc, Nathalie, Zelada, Alicia, Martineau, Philippe, Bouillon, Marlène, Magee, Beatrice B, Passeron, Susana, Giasson, Luc, Cantore, Marı́a L
Format:	Artikel
Sprache:	eng
Schlagworte:	cAMP cAMP-dependent protein kinase Candida albicans Candida albicans - enzymology Candida albicans - genetics Candida albicans - growth & development Candidiasis - microbiology Candidiasis - pathology Catalytic Domain Culture Media Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Gene Deletion Gene Expression Regulation, Enzymologic Gene Expression Regulation, Fungal Genetic Complementation Test Humans Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Morphogenesis Mutation
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