General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system

Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin syst...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2003-03, Vol.284 (3), p.F518-F524
Hauptverfasser:	Castrop, Hayo, Klar, Jurgen, Wagner, Charlotte, Hocherl, Klaus, Kurtz, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Feedback, Physiological - drug effects Feedback, Physiological - physiology Furosemide - pharmacology Immunohistochemistry Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Kidney Cortex - drug effects Kidney Cortex - enzymology Kidney Cortex - metabolism Male Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley Renal Artery Obstruction - metabolism Renin - genetics Renin - metabolism Renin-Angiotensin System - physiology RNA, Messenger - metabolism Sodium, Dietary - pharmacology
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