Taurine-induced synaptic potentiation and the late phase of long-term potentiation are related mechanistically

The application of taurine (2-aminoethanesulfonic acid) induces a long-lasting increase of synaptic efficacy and axon excitability (LLP-TAU) in rat hippocampal CA1 area. After taurine withdrawal, LLP-TAU lasted at least 3 h. This fact prompted us to assess whether the mechanisms involved in the main...

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Veröffentlicht in:	Neuropharmacology 2003, Vol.44 (1), p.26-39
Hauptverfasser:	del Olmo, N., Handler, A., Alvarez, L., Bustamante, J., Martín del Río, R., Solís, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors CREB Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Excitatory Postsynaptic Potentials - drug effects Female Fiber volley Fundamental and applied biological sciences. Psychology Hippocampus - physiology Hippocampus - ultrastructure In Vitro Techniques Long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Phosphorylation Protein kinase C Protein Kinase C - antagonists & inhibitors Protein synthesis Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Receptors, Dopamine D5 Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Taurine Taurine - pharmacology Taurine - physiology Vertebrates: nervous system and sense organs
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