Telomere shortening in leukocyte subpopulations from baboons
To address questions about telomere length regulation in nonhuman primates, we studied the telomere length in subpopulations of leukocytes from the peripheral blood of baboons aged 0.2–26.5 years. Telomere length in granulocytes, B cells, and subpopulations of T cells all decreased with age. Overall...
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| Veröffentlicht in: | Journal of leukocyte biology 2003-02, Vol.73 (2), p.289-296 |
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| container_title | Journal of leukocyte biology |
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| creator | Baerlocher, Gabriela M. Mak, Jennifer Röth, Alexander Rice, Karen S. Lansdorp, Peter M. |
| description | To address questions about telomere length regulation in nonhuman primates, we studied the telomere length in subpopulations of leukocytes from the peripheral blood of baboons aged 0.2–26.5 years. Telomere length in granulocytes, B cells, and subpopulations of T cells all decreased with age. Overall, telomere length kinetics were lineage‐ and cell subset‐specific. T cells showed the most pronounced, overall decline in elomere length. Levels of telomerase in stimulated T cells from old animals were lower than in corresponding cells from young animals. Memory T cells with very short telomeres accumulated in old animals. In contrast, the average telomere length values in B cells remained relatively constant from middle age onward. Individual B cells showed highly variable telomere length, and B cells with very long telomeres were observed after the ages of 1–2 years. In general, cell type‐specific telomere kinetics in baboons were remarkably similar to those observed in humans. |
| doi_str_mv | 10.1189/jlb.0702361 |
| format | Article |
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In general, cell type‐specific telomere kinetics in baboons were remarkably similar to those observed in humans.</description><subject>Aging - genetics</subject><subject>Animals</subject><subject>B lymphocytes</subject><subject>Female</subject><subject>flow‐FISH</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Papio</subject><subject>replicative history</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - enzymology</subject><subject>Telomerase - metabolism</subject><subject>Telomere</subject><subject>telomere length</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun6cvEsvepHqTNI2CXhR8ZMFL-s5pGnqVtNmTbaU_fd22QVvehpmeN534CHkFOEKUcjrT1deAQfKCtwhE5RMpKzgbJdMgGeY5hnAATmM8RMAGC1gnxwgzfNMQDEhNzPrfGuDTeLch6Xtmu4jabrE2f7Lm9VyvPflwi96p5eN72JSB98mpS79uByTvVq7aE-284i8Pz7M7p_T6dvTy_3tNDVMcJlKpiWVlAtdMCaMNCbP0XAUlFqNnFaMo-SmBKRVTUuGWGcFGqgkVqaqa3ZELja9i-C_exuXqm2isc7pzvo-Kk6lyAUv_gVRFJKDzEbwcgOa4GMMtlaL0LQ6rBSCWltVo1W1tTrSZ9vavmxt9ctuNY4AbIChcXb1V5d6nd4BFXKMnG8i8-ZjPjTBqthq58YPVA3DwJmias39AIeVjfs</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Baerlocher, Gabriela M.</creator><creator>Mak, Jennifer</creator><creator>Röth, Alexander</creator><creator>Rice, Karen S.</creator><creator>Lansdorp, Peter M.</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Telomere shortening in leukocyte subpopulations from baboons</title><author>Baerlocher, Gabriela M. ; Mak, Jennifer ; Röth, Alexander ; Rice, Karen S. ; Lansdorp, Peter M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3879-93a929278a6338c9cc551c71822ea172d37197cb012df2b311f461c0d91dcdff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aging - genetics</topic><topic>Animals</topic><topic>B lymphocytes</topic><topic>Female</topic><topic>flow‐FISH</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Papio</topic><topic>replicative history</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - enzymology</topic><topic>Telomerase - metabolism</topic><topic>Telomere</topic><topic>telomere length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baerlocher, Gabriela M.</creatorcontrib><creatorcontrib>Mak, Jennifer</creatorcontrib><creatorcontrib>Röth, Alexander</creatorcontrib><creatorcontrib>Rice, Karen S.</creatorcontrib><creatorcontrib>Lansdorp, Peter M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baerlocher, Gabriela M.</au><au>Mak, Jennifer</au><au>Röth, Alexander</au><au>Rice, Karen S.</au><au>Lansdorp, Peter M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomere shortening in leukocyte subpopulations from baboons</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>73</volume><issue>2</issue><spage>289</spage><epage>296</epage><pages>289-296</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>To address questions about telomere length regulation in nonhuman primates, we studied the telomere length in subpopulations of leukocytes from the peripheral blood of baboons aged 0.2–26.5 years. 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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Aging - genetics Animals B lymphocytes Female flow‐FISH Leukocytes - metabolism Male Papio replicative history T lymphocytes T-Lymphocytes - enzymology Telomerase - metabolism Telomere telomere length |
| title | Telomere shortening in leukocyte subpopulations from baboons |
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