Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
Two outbred mouse lines, phenotypically selected for differential subcutaneous (s.c.) acute inflammatory response (AIR), were analysed for urethane-induced lung inflammatory response and susceptibility to lung tumorigenesis. AIR min mice, which show a low response to s.c. acute inflammation, develop...
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| Veröffentlicht in: | Oncogene 2003-01, Vol.22 (3), p.426-432 |
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| creator | Maria, Durvanei Augusto Manenti, Giacomo Galbiati, Federica Ribeiro, Orlando Garcia Cabrera, Wafa Hanna Koury Barrera, Roberto Giannì Pettinicchio, Angela Franco, Marcelo De Starobinas, Nancy Siqueira, Maria Dragani, Tommaso A Ibañez, Olga Martinez |
| description | Two outbred mouse lines, phenotypically selected for differential subcutaneous (s.c.) acute inflammatory response (AIR), were analysed for urethane-induced lung inflammatory response and susceptibility to lung tumorigenesis. AIR
min
mice, which show a low response to s.c. acute inflammation, developed a persistent subacute lung inflammatory response and a 40-fold higher lung tumor multiplicity than did AIR
max
mice, which are selected for high response to s.c. acute inflammation and showed a transient lung inflammatory response. A highly significant linkage disequilibrium pattern was observed in AIR
max
and AIR
min
mice at marker alleles located within a 452-kb pulmonary adenoma susceptibility 1 (
Pas1
) locus region, thus defining the location of gene candidacy for inflammatory response and for the biological effects of
Pas1
in this region. AIR
min
and AIR
max
mice segregated by descent the
Pas1
s
and
Pas1
r
alleles, respectively, providing evidence for the involvement of the
Pas1
locus in the inflammatory response. The 452-kb region contains
Kras2
and four additional genes, including the lymphoid-restricted membrane protein (
Lrmp
) gene, whose Pro→Leu nonconservative variation was linked with inflammatory response and
Pas1
allelotype. These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation. |
| doi_str_mv | 10.1038/sj.onc.1206157 |
| format | Article |
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min
mice, which show a low response to s.c. acute inflammation, developed a persistent subacute lung inflammatory response and a 40-fold higher lung tumor multiplicity than did AIR
max
mice, which are selected for high response to s.c. acute inflammation and showed a transient lung inflammatory response. A highly significant linkage disequilibrium pattern was observed in AIR
max
and AIR
min
mice at marker alleles located within a 452-kb pulmonary adenoma susceptibility 1 (
Pas1
) locus region, thus defining the location of gene candidacy for inflammatory response and for the biological effects of
Pas1
in this region. AIR
min
and AIR
max
mice segregated by descent the
Pas1
s
and
Pas1
r
alleles, respectively, providing evidence for the involvement of the
Pas1
locus in the inflammatory response. The 452-kb region contains
Kras2
and four additional genes, including the lymphoid-restricted membrane protein (
Lrmp
) gene, whose Pro→Leu nonconservative variation was linked with inflammatory response and
Pas1
allelotype. These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1206157</identifier><identifier>PMID: 12545163</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenoma - genetics ; Animals ; Animals, Outbred Strains ; Apoptosis ; Biological and medical sciences ; Cancer ; Cell Biology ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Fundamental and applied biological sciences. Psychology ; Genetic Markers ; Genetic Predisposition to Disease ; Human Genetics ; Internal Medicine ; Leukocytes ; Linkage Disequilibrium ; Lung Neoplasms - genetics ; Lungs ; Medicine ; Medicine & Public Health ; Membrane Proteins - genetics ; Mice ; Molecular and cellular biology ; Molecular Sequence Data ; Oncology ; original-paper ; Pneumonia - genetics ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins p21(ras) ; Quantitative Trait Loci ; ras Proteins ; Tumorigenesis ; Tumors</subject><ispartof>Oncogene, 2003-01, Vol.22 (3), p.426-432</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 23, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-fa3ed76fc4fa58153086d5bda20545763c9db67e02ba58046220f56132a669763</citedby><cites>FETCH-LOGICAL-c486t-fa3ed76fc4fa58153086d5bda20545763c9db67e02ba58046220f56132a669763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1206157$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1206157$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14680631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12545163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maria, Durvanei Augusto</creatorcontrib><creatorcontrib>Manenti, Giacomo</creatorcontrib><creatorcontrib>Galbiati, Federica</creatorcontrib><creatorcontrib>Ribeiro, Orlando Garcia</creatorcontrib><creatorcontrib>Cabrera, Wafa Hanna Koury</creatorcontrib><creatorcontrib>Barrera, Roberto Giannì</creatorcontrib><creatorcontrib>Pettinicchio, Angela</creatorcontrib><creatorcontrib>Franco, Marcelo De</creatorcontrib><creatorcontrib>Starobinas, Nancy</creatorcontrib><creatorcontrib>Siqueira, Maria</creatorcontrib><creatorcontrib>Dragani, Tommaso A</creatorcontrib><creatorcontrib>Ibañez, Olga Martinez</creatorcontrib><title>Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Two outbred mouse lines, phenotypically selected for differential subcutaneous (s.c.) acute inflammatory response (AIR), were analysed for urethane-induced lung inflammatory response and susceptibility to lung tumorigenesis. AIR
min
mice, which show a low response to s.c. acute inflammation, developed a persistent subacute lung inflammatory response and a 40-fold higher lung tumor multiplicity than did AIR
max
mice, which are selected for high response to s.c. acute inflammation and showed a transient lung inflammatory response. A highly significant linkage disequilibrium pattern was observed in AIR
max
and AIR
min
mice at marker alleles located within a 452-kb pulmonary adenoma susceptibility 1 (
Pas1
) locus region, thus defining the location of gene candidacy for inflammatory response and for the biological effects of
Pas1
in this region. AIR
min
and AIR
max
mice segregated by descent the
Pas1
s
and
Pas1
r
alleles, respectively, providing evidence for the involvement of the
Pas1
locus in the inflammatory response. The 452-kb region contains
Kras2
and four additional genes, including the lymphoid-restricted membrane protein (
Lrmp
) gene, whose Pro→Leu nonconservative variation was linked with inflammatory response and
Pas1
allelotype. These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation.</description><subject>Adenoma - genetics</subject><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Human Genetics</subject><subject>Internal Medicine</subject><subject>Leukocytes</subject><subject>Linkage Disequilibrium</subject><subject>Lung Neoplasms - genetics</subject><subject>Lungs</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane Proteins - genetics</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Oncology</subject><subject>original-paper</subject><subject>Pneumonia - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>Quantitative Trait Loci</subject><subject>ras Proteins</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1rFTEUhoMo9tq6dSmDRdHF3CaZydeyFG2Fil3UdchkkjKXmeSaM7Pov_eUO3BBKpLFgbzP-XwJecfoltFGX8Bum5PfMk4lE-oF2bBWyVoI074kG2oErQ1v-Al5A7CjlCpD-WtywrhoBZPNhvy4W8YpJ1ceK9eHlCdXwQI-7OehG8ZhfqxY9fnOAftSjdkvULkYg5-hGlIc3TS5OWNqCbDPCcIZeRXdCOHtGk_Jr29f769u6tuf19-vLm9r32o519E1oVcy-jY6oZloqJa96HrHKc6lZONN30kVKO9Qp63knEYhWcOdlAb1U_LpUHdf8u8lwGynAYceR5dCXsAqbrRQwvwXZFoq1bYUwQ9_gbu8lIRLWGyOpzVcIXR-gB7cGCxeIM_F-aeK9pJpw5mmWiO1fYbC14dp8DmFOOD_cwm-ZIASot2XYUJLLKP2yWULO4su29VlTHi_Drt0U-iP-GorAh9XwIF3Yywu-QGOXCs1lQ1D7uLAAUrpIZTj1v9o_QfBnLz-</recordid><startdate>20030123</startdate><enddate>20030123</enddate><creator>Maria, Durvanei Augusto</creator><creator>Manenti, Giacomo</creator><creator>Galbiati, Federica</creator><creator>Ribeiro, Orlando Garcia</creator><creator>Cabrera, Wafa Hanna Koury</creator><creator>Barrera, Roberto Giannì</creator><creator>Pettinicchio, Angela</creator><creator>Franco, Marcelo De</creator><creator>Starobinas, Nancy</creator><creator>Siqueira, Maria</creator><creator>Dragani, Tommaso A</creator><creator>Ibañez, Olga Martinez</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030123</creationdate><title>Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response</title><author>Maria, Durvanei Augusto ; Manenti, Giacomo ; Galbiati, Federica ; Ribeiro, Orlando Garcia ; Cabrera, Wafa Hanna Koury ; Barrera, Roberto Giannì ; Pettinicchio, Angela ; Franco, Marcelo De ; Starobinas, Nancy ; Siqueira, Maria ; Dragani, Tommaso A ; Ibañez, Olga Martinez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-fa3ed76fc4fa58153086d5bda20545763c9db67e02ba58046220f56132a669763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenoma - genetics</topic><topic>Animals</topic><topic>Animals, Outbred Strains</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Markers</topic><topic>Genetic Predisposition to Disease</topic><topic>Human Genetics</topic><topic>Internal Medicine</topic><topic>Leukocytes</topic><topic>Linkage Disequilibrium</topic><topic>Lung Neoplasms - genetics</topic><topic>Lungs</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membrane Proteins - genetics</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Oncology</topic><topic>original-paper</topic><topic>Pneumonia - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins p21(ras)</topic><topic>Quantitative Trait Loci</topic><topic>ras Proteins</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maria, Durvanei Augusto</creatorcontrib><creatorcontrib>Manenti, Giacomo</creatorcontrib><creatorcontrib>Galbiati, Federica</creatorcontrib><creatorcontrib>Ribeiro, Orlando Garcia</creatorcontrib><creatorcontrib>Cabrera, Wafa Hanna Koury</creatorcontrib><creatorcontrib>Barrera, Roberto Giannì</creatorcontrib><creatorcontrib>Pettinicchio, Angela</creatorcontrib><creatorcontrib>Franco, Marcelo De</creatorcontrib><creatorcontrib>Starobinas, Nancy</creatorcontrib><creatorcontrib>Siqueira, Maria</creatorcontrib><creatorcontrib>Dragani, Tommaso A</creatorcontrib><creatorcontrib>Ibañez, Olga Martinez</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maria, Durvanei Augusto</au><au>Manenti, Giacomo</au><au>Galbiati, Federica</au><au>Ribeiro, Orlando Garcia</au><au>Cabrera, Wafa Hanna Koury</au><au>Barrera, Roberto Giannì</au><au>Pettinicchio, Angela</au><au>Franco, Marcelo De</au><au>Starobinas, Nancy</au><au>Siqueira, Maria</au><au>Dragani, Tommaso A</au><au>Ibañez, Olga Martinez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2003-01-23</date><risdate>2003</risdate><volume>22</volume><issue>3</issue><spage>426</spage><epage>432</epage><pages>426-432</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Two outbred mouse lines, phenotypically selected for differential subcutaneous (s.c.) acute inflammatory response (AIR), were analysed for urethane-induced lung inflammatory response and susceptibility to lung tumorigenesis. AIR
min
mice, which show a low response to s.c. acute inflammation, developed a persistent subacute lung inflammatory response and a 40-fold higher lung tumor multiplicity than did AIR
max
mice, which are selected for high response to s.c. acute inflammation and showed a transient lung inflammatory response. A highly significant linkage disequilibrium pattern was observed in AIR
max
and AIR
min
mice at marker alleles located within a 452-kb pulmonary adenoma susceptibility 1 (
Pas1
) locus region, thus defining the location of gene candidacy for inflammatory response and for the biological effects of
Pas1
in this region. AIR
min
and AIR
max
mice segregated by descent the
Pas1
s
and
Pas1
r
alleles, respectively, providing evidence for the involvement of the
Pas1
locus in the inflammatory response. The 452-kb region contains
Kras2
and four additional genes, including the lymphoid-restricted membrane protein (
Lrmp
) gene, whose Pro→Leu nonconservative variation was linked with inflammatory response and
Pas1
allelotype. These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12545163</pmid><doi>10.1038/sj.onc.1206157</doi><tpages>7</tpages></addata></record> |
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| ispartof | Oncogene, 2003-01, Vol.22 (3), p.426-432 |
| issn | 0950-9232 1476-5594 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoma - genetics Animals Animals, Outbred Strains Apoptosis Biological and medical sciences Cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Genetic Markers Genetic Predisposition to Disease Human Genetics Internal Medicine Leukocytes Linkage Disequilibrium Lung Neoplasms - genetics Lungs Medicine Medicine & Public Health Membrane Proteins - genetics Mice Molecular and cellular biology Molecular Sequence Data Oncology original-paper Pneumonia - genetics Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) Quantitative Trait Loci ras Proteins Tumorigenesis Tumors |
| title | Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response |
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