Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor

Vascular restenosis attributable to intimal thickening remains a major problem after percutaneous transluminal coronary angioplasty (PTCA). Through differential-display analysis, we have identified a novel gene whose expression was increased after catheter injury of rabbit aorta. The gene that is ex...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-01, Vol.107 (2), p.313-319
Hauptverfasser:	TSUKADA, Shuichi, IWAI, Masaru, NISHIU, Jun, ITOH, Makoto, TOMOIKE, Hitonobu, HORIUCHI, Masatsugu, NAKAMURA, Yusuke, TANAKA, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aorta - metabolism Aorta - pathology Base Sequence Biological and medical sciences Cell Line Chromosomes, Human, Pair 13 - genetics Constriction, Pathologic - genetics Constriction, Pathologic - pathology Constriction, Pathologic - prevention & control COS Cells Disease Models, Animal Diseases of the cardiovascular system Femoral Artery - metabolism Femoral Artery - pathology Gene Targeting GTP-Binding Proteins - metabolism Humans Immunohistochemistry Medical sciences Mice Mice, Knockout Molecular Sequence Data Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Organ Specificity Rabbits Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA, Messenger - metabolism Tunica Intima - metabolism Tunica Intima - pathology Tunica Media - metabolism Tunica Media - pathology
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