Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem

Eukaryotic DNA replication initiates at multiple origins. In early fly and frog embryos, chromosomal replication is very rapid and initiates without sequence specificity. Despite this apparent randomness, the spacing of these numerous initiation sites must be sufficiently regular for the genome to b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	BioEssays 2003-02, Vol.25 (2), p.116-125
Hauptverfasser:	Hyrien, Olivier, Marheineke, Kathrin, Goldar, Arach
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anura Chromatin - metabolism DNA Replication - genetics DNA Replication - physiology Eukaryotic Cells Humans Models, Biological Nuclear Proteins - metabolism Replication Origin Replicon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!