A central role for peripheral dendritic cells in the induction of acquired thymic tolerance

Despite extensive negative selection in the thymus, numerous clones of self-reactive T cells are normally exported to the periphery. In most instances, autoimmunity is prevented by regulatory T (Tr) cells, many of which are also of recent thymic origin. We have demonstrated recently that natural kil...

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Veröffentlicht in:	Trends in immunology 2003-02, Vol.24 (2), p.77-81
Hauptverfasser:	Goldschneider, Irving, Cone, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cloning Dendritic Cells - immunology Diabetes Immune system Immune Tolerance Immunotherapy Lymphocytes Mice Models, Immunological Population T cell receptors T-Lymphocytes - immunology Thymus Gland - immunology
Online-Zugang:	Volltext
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